Lisa Cannon‐Albright
A5053283545- Genetic Associations and Epidemiology
- Prostate Cancer Treatment and Research
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Bioinformatics and Genomic Networks
- Molecular Biology Techniques and Applications
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Colorectal Cancer Treatments and Studies
- Genetic and phenotypic traits in livestock
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Global Cancer Incidence and Screening
- melanin and skin pigmentation
- Hormonal and reproductive studies
- Pelvic floor disorders treatments
- MicroRNA in disease regulation
University of Utah
2015-2024
George E. Wahlen Department of VA Medical Center
2015-2024
Huntsman (United States)
2023
Huntsman Cancer Institute
2013-2023
United States Department of Veterans Affairs
2011-2020
University of Utah Health Care
2019
Brigham Young University
2018-2019
Utah State University
2019
Lake City VA Medical Center
2019
Prostate Cancer UK
2018
A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have detected in five of eight kindreds presumed segregate alleles. The include an 11-base pair deletion, a 1-base insertion, stop codon, missense substitution, inferred regulatory mutation. gene is expressed numerous tissues, including ovary, encodes predicted protein 1863 amino acids. This contains...
SummaryThe contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage mutation analysis in 237 families, each with at least four cases cancer, collected the Breast Cancer Linkage Consortium. Families were included without regard occurrence ovarian or other cancers. Overall, disease linked an estimated 52% 32% neither gene 16% (95% confidence interval [CI] 6%–28%), suggesting predisposition genes. The majority (81%) breast-ovarian families due BRCA1, most others (14%)...
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance dominant susceptibility genes conferring high risk disease. genomic linkage search was performed with 15 high-risk cancer families that were unlinked BRCA1 locus on chromosome 17q21. This analysis localized second locus, BRCA2 , 6-centimorgan interval 13q12-13. Preliminary evidence suggests confers but, unlike does not confer substantially elevated ovarian cancer.
Journal Article Systematic Population-Based Assessment of Cancer Risk in First-Degree Relatives Probands Get access David. E. Goldgar, Goldgar Search for other works by this author on: Oxford Academic PubMed Google Scholar Douglas. F. Easton, Easton Lisa. A. Cannon-Albright, Cannon-Albright Mark H. Skolnick JNCI: the National Institute, Volume 86, Issue 21, 2 November 1994, Pages 1600–1608, https://doi.org/10.1093/jnci/86.21.1600 Published: 02 1994 history Received: 29 March Revision...
The availability of genetic testing for inherited mutations in the BRCA1 gene provides potentially valuable information to women at high risk breast or ovarian cancer; however, carriers have few clinical management options reduce their cancer risk. Decreases hormone exposure following bilateral prophylactic oophorectomy (i.e., surgical removal ovaries) may alter mutation carriers. This study was undertaken evaluate whether is associated with a reduction carriers.We studied cohort...
Linkage analysis of ten Utah kindreds and one Texas kindred with multiple cases cutaneous malignant melanoma (CMM) provided evidence that a locus for familial susceptibility is in the chromosomal region 9p13-p22. The genetic markers analyzed reside candidate on chromosome 9p21, previously implicated by presence homozygous deletions tumors germline deletion an individual eight independent melanomas. Multipoint linkage was performed between (MLM) two short tandem repeat markers, D9S126...
We studied 670 persons in 34 kindreds by flexible proctosigmoidoscopic examination (60 cm) to determine how frequently colorectal adenomas and cancers result from an inherited susceptibility. Kindreds were selected through either a single person with adenomatous polyp or cluster of relatives coIonic cancer. The all had common cancers, not the rare conditions familial polyposis coli nonpolyposis Likelihood analysis strongly supported dominant inheritance susceptibility gene frequency 19...
Abstract GenoMEL, comprising major familial melanoma research groups from North America, Europe, Asia, and Australia has created the largest sample yet available to characterize mutations in high-risk susceptibility genes CDKN2A/alternate reading frames (ARF), which encodes p16 p14ARF, CDK4 evaluate their relationship with pancreatic cancer (PC), neural system tumors (NST), uveal (UM). This study included 466 families (2,137 patients) at least three patients 17 GenoMEL centers. Overall, 41%...
<b>Background:</b> The major factors individually reported to be associated with an increased frequency of CDKN2A mutations are number patients melanoma in a family, early age at diagnosis, and family members multiple primary melanomas (MPM) or pancreatic cancer. <b>Methods:</b> These four features were examined 385 families ⩾3 pooled by 17 GenoMEL groups, these attributes compared across continents. <b>Results:</b> Overall, 39% had ranging from 20% (32/162) Australia 45% (29/65) North...
Abstract It remains elusive whether some of the associations identified in genome-wide association studies prostate cancer (PrCa) may be due to regulatory effects genetic variants on CpG sites, which further influence expression PrCa target genes. To search for sites associated with risk, here we establish models predict methylation (N = 1,595) and conduct analyses risk (79,194 cases 61,112 controls). We identify 759 showing an association, including 15 located at novel loci. Among those 42...
<h3>Abstract</h3> <h3>Objectives</h3> To develop and validate a genetic tool to predict age of onset aggressive prostate cancer (PCa) guide decisions who screen at what age. <h3>Design</h3> Analysis genotype, PCa status, select single nucleotide polymorphisms (SNPs) associated with diagnosis. These were incorporated into survival analysis estimate their effects on diagnosis (that is, not eligible for surveillance according National Comprehensive Cancer Network guidelines; any Gleason score...
MR scans of 87 pediatric patients with brain stem gliomas were retrospectively reviewed to develop a new classification scheme based on imaging. The that has been developed utilizes primarily T2-weighted images, as these most accurately show tumor extent. Tumors are characterized location origin, focality, direction and extent growth, degree enlargement, exophytic presence or absence cysts, necrosis, hemorrhage, hydrocephalus. use this allowed identification differences in population who...