A5090342798- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Intestinal and Peritoneal Adhesions
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- PARP inhibition in cancer therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Metabolism and Genetic Disorders
- MicroRNA in disease regulation
- Cancer Risks and Factors
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Reproductive Biology and Fertility
- Gynecological conditions and treatments
- Extracellular vesicles in disease
- Radiomics and Machine Learning in Medical Imaging
- Maternal and fetal healthcare
- Lung Cancer Treatments and Mutations
- Morinda citrifolia extract uses
Second Affiliated Hospital of Zhengzhou University
2015-2024
Henan Provincial Center for Disease Control and Prevention
2023
The University of Texas MD Anderson Cancer Center
2023
AstraZeneca (Brazil)
2023
China Medical University
2020
Peking Union Medical College Hospital
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Zhengzhou University
2015-2020
First Affiliated Hospital Zhejiang University
2020
Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially pMMR
Abstract Purpose To develop and validate a deep learning‐based pathological risk score (RS) with an aim of predicting patients' prognosis to investigate the potential association between information within whole slide image (WSI) cervical cancer prognosis. Methods A total 251 patients International Federation Gynecology Obstetrics (FIGO) Stage IA1–IIA2 who underwent surgery without any preoperative treatment were enrolled in this study. Both clinical characteristics WSI each patient...
The main obstacle in the development of an effective tumor vaccine is inherent ability tumors to evade immune responses. Tumors often use common mechanisms and regulators system. present study aimed analyze expression levels indoleamine 2,3-dioxygenase (IDO), programmed death-ligand (PD-L) 1, PD-L2, B7-H4, galectin-1 galectin-3 tissue samples from patients with endometrial carcinoma, order detect immunosuppressive environment carcinomas. IDO, PD-L1, PD-L2 B7-H4 were analyzed by...
Abstract: Aberrant expression of oncogenes and/or tumor suppressors play a fundamental effect on the pathogenesis and tumorigenicity cervical cancer (CC). B-cell CLL/lymphoma 3 (BCL3) was previously found to be putative proto-oncogene in human cancers regulated signal transducer activator transcription (STAT3), critical oncogene, CC cell line. However, its status, clinical significance biological functions remain largely unclear. The expressions BCL3 STAT3 specimens were determined by...
The development of chemotherapy resistance is a major obstacle for cervical cancer (CC) patients. Exosome-mediated transfer circular RNAs (circRNAs) was found to have relevance the CC. This study designed explore role and mechanism exosomal circRNA synaptotagmin 15 (circSYT15) on cisplatin (DDP) in Cell proliferation ability apoptosis rate were detected by Counting Kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), colony formation, flow cytometry assays. CircSYT15, microRNA-503-5p...
The purpose of this study was to investigate whether fertilization failure after in vitro could be explained by polymorphisms MT-ATP6 and MT-CYB genes. We performed a prospective comparative 111 fresh IVF cycles Han Chinese between July 2011 February 2013. Human sperm mitochondrial DNA (mtDNA) variants the genes were screened polymerase chain reaction (PCR) direct sequencing. Forty-six couples had low rates (< or =30%) total failure, 65 controls with normal fertilization. One unreported...
This study explored the rationality of 2018 International Federation Gynecology and Obstetrics (FIGO) stage IIIC for cervical cancer to determine outcomes.We conducted a retrospective patients who had received radical surgery or Radiotherapy. Multivariate analysis was used compare 5-year overall survival (OS) disease-free (DFS) FIGO stages IIIA, IIIB, patients. Based on tumor-node-metastasis (TNM) staging, cases were divided into 5 subgroups: T1a, T1b, T2a, T2b, T3. The OS DFS different...
Purpose: To evaluate the survival outcomes of abdominal Q-M type B and C2 radical hysterectomy (RH) for early-stage (IA1 (lymphovascular invasion)-IIA2) cervical cancer. Patients methods: Based on this multicenter, retrospective cohort study clinical diagnosis treatment cancer in China (Four C), RH were compared under real-world matched conditions. Results: In total, 46,313 cases included Four C database, among whom 20,018 underwent or RH. study, no differences found 5-year overall (OS)...
In the present study, differentially expressed microRNAs (miRNAs) in peritoneal exosomes that were isolated from 10 patients with epithelial ovarian cancer (EOC) metastasis abdominal cavity and participants without (NC) identified. These miRNAs revealed by next-generation sequencing categorized Gene Ontology enrichment Kyoto Encyclopedia of Genes Genomes pathway analysis their target genes. Notably, two associated EOC-miR-149-3p miR-222-5p-were There significant differences expression...
<h3>Introduction</h3> Current therapies for platinum-resistant ovarian cancer (PROC) are primarily non-platinum chemotherapies with limited response and an important unmet clinical need. Mirvetuximab soravtansine (MIRV) is a folate receptor α (FRα)-directed antibody-drug conjugate which had been approved by FDA in Nov-2022 FRα positive PROC. IMGN853–301 single-arm registration study to evaluate the efficacy safety of MIRV Chinese PROC patients. <h3>Methods</h3> 35 patients were enrolled 51%...
Objective To compare the 5-year overall survival (OS) and disease-free (DFS) of patients with cervical cancer who received neoadjuvant chemotherapy followed by surgery (NACT) those abdominal radical hysterectomy alone (ARH). Methods We retrospectively compared oncological outcomes 1410 stage IB3 NACT (n=583) or ARH (n=827). The in group were divided into an NACT-sensitive NACT-insensitive according to their response chemotherapy. Results significantly better than (OS: 96.2% vs. 91.2%,...
Endometrial cancer is one of the most common malignant tumours in women, and stem cells are known to play an important role its growth, invasion, metastasis, drug resistance. Immunotherapy for endometrial still under research. In this study, a total 547 cases were randomly divided into training set (351 cases) test (196 cases). The stemness index patients was calculated using One-Class Logistic Regression (OCLR) machine learning algorithm explore clinicopathological differences between...
Adenomyosis (AM) is a common gynecological disorder that can cause pelvic pain. The regulatory role of long noncoding RNAs (lncRNAs) in AM progression has been widely reported. This study investigated the effect and mechanism lncRNA taurine-upregulated gene 1 (TUG1) on endometrial epithelial cells (EECs) AM.Endometrial tissues patients controls were collected. A murine model was established by tamoxifen induction. TUG1 expression mice determined. In vivo, measured through H&E staining,...
Abstract Background Cervical cancer is the fourth most common in women. N 6 -dimethyladenosine (m A) mRNA methylation closely associated with cervical cancer. Methods Using TCGA database, we studied expression and mutation of m A-related genes squamous cell carcinoma endocervical adenocarcinoma (CESC) obtained genetic characteristics based on an A risk model prognostic value A. We effects score immune features genomic changes patients CESC, evaluated sensitivity CESC to different...
Brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB), vascular endothelial growth (VEGF) and CD105 are highly expressed in several types of cancer. The present study aimed to determine whether BDNF, TrkB, VEGF associated with the prognosis metastasis patients cervical squamous cell carcinoma (SCC) at IB2 stage. A total 79 IB2-stage SCC were enrolled study. expression levels cancer tissue detected by immunohistochemistry their association clinicopathological indexes...
Recent studies have highlighted that N6-methyladenosine (m6A) plays a significant role in tumorigenicity and progression. However, the mechanism of m6A modifications tumor microenvironment (TME) immune cell infiltration cervical cancer (CC) remains unclear. Clinical RNA sequencing data 25 methylation regulators were acquired from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) database. LASSO Cox regression analysis was used to generate prognostic risk signature. modification...
This study aimed to construct a lymph node metastasis-related gene signature predict prognosis and immune infiltration in patients with cervical cancer.Clinical RNA sequencing data of 193 cancer, which were divided into metastasis (N1) non-lymph (N0) groups, acquired from TCGA. Differentially expressed genes (DEGs) between the N1 N0 groups detected, protein-protein interaction combined LASSO analysis was conducted further screen genes. Univariate multivariate Cox regression analyses...
In this study, we aimed to investigate the associations of mitochondrial DNA (mtDNA) haplogroups and variants with in vitro fertilization (IVF) failure. A retrospective, comparative study 260 fresh IVF cycles a Han Chinese population was performed from July 2011 April 2014. Seventy-three couples had low rates (≤30%) or total failure, 187 controls normal were included. Human sperm mtDNA determined by polymerase chain reaction (PCR), nested PCR direct sequencing. One unreported point variant,...
Hysteroscopy is an effective tool to diagnose and treat abnormal uterine bleeding or cavity abnormalities, especially precancerous cancerous disorders. In this study, we proposed Endometrial Cancer (EC) Computer-Aided Diagnosis System (ECCADx) based on deep learning boost the diagnostic accuracy for recognizing Atypical Hyperplasia (AEH) EC. ECCADx was developed using a training dataset with 49,646 images from 1,237 patients in Maternal Child Hospital of Hubei Province (MCH) two test...
Cervical cancer is the third most commonly diagnosed in women. The human wings apart‑like (hWAPL) gene, which 30,793 bp long and located on 10q23.2., a homologue of WAPL gene Drosophila melanogaster. hWAPL has characteristics an oncogene uterine cervical cancer. present study investigated expression tissues, including 9 common cancers, consisting cervical, gastric lung liver, bladder, esophageal, endometrial, renal rectal carcinomas, intraepithelial neoplasia (CIN) benign squamous epithelia....
Abstract Background The preservation of fertility and integrity the reproductive organs has increasingly been concern to most women with adenomyosis. Adenomyomectomy is conservative surgery that now widely applied; however, relapse a serious problem after operation. Postoperative treatment, such as gonadotropin-releasing hormone agonist (GnRHa) suggested result in reducing rate disease recurrence. However, there still lack evidence from randomized clinical trials examining efficacy GnRHa...