A5101898374- Genomics and Chromatin Dynamics
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Epigenetics and DNA Methylation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Glaucoma and retinal disorders
- Neuroendocrine Tumor Research Advances
- Plant-Microbe Interactions and Immunity
- Postharvest Quality and Shelf Life Management
- Ovarian cancer diagnosis and treatment
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Optical Coherence Tomography Applications
- Plant Molecular Biology Research
- Plant Physiology and Cultivation Studies
- RNA modifications and cancer
- Plant Reproductive Biology
- Lung Cancer Research Studies
- Photosynthetic Processes and Mechanisms
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Gestational Trophoblastic Disease Studies
- PARP inhibition in cancer therapy
Fujian Provincial Cancer Hospital
2017-2024
Affiliated Hospital of Hebei University
2024
Hainan University
2024
Pennsylvania State University
2015-2023
State Key Laboratory of Plant Genomics
2018-2023
Chinese Academy of Sciences
2018-2023
Affiliated Hospital of North Sichuan Medical College
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
John Wiley & Sons (United Kingdom)
2023
Quantitative measurements based on optical coherence tomographic angiography (OCTA) may have value in managing diabetic retinopathy (DR), but there is limited information the ability of OCTA to distinguish eyes with DR.To evaluate retinal microvasculature using healthy from DR.In this prospective cross-sectional study, was used examine participants type 2 diabetes or without DR and September 17, 2015, April 6, 2016. Density maps superficial layer (SRL) deeper (DRL) images were generated...
Purpose: The purpose of this study was to compare imaging choroidal neovascularization (CNV) using swept-source (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA). Methods: Optical performed a 100-kHz SS-OCT instrument 68-kHz SD-OCTA (Carl Zeiss Meditec, Inc.). Both 3 × 3- 6 6-mm2 scans were obtained on both instruments. 3-mm2 SS-OCTA consisted 300 A-scans per B-scan at positions, the 245 positions. 420 350 B-scans repeated four times each position in twice scans....
Although Hi-C technology is one of the most popular tools for studying 3D genome organization, due to sequencing cost, resolution datasets are coarse and cannot be used link distal regulatory elements their target genes. Here we develop HiCPlus, a computational approach based on deep convolutional neural network, infer high-resolution interaction matrices from low-resolution data. We demonstrate that HiCPlus can impute highly similar original ones, while only using 1/16 reads. show models...
Fangcang shelter hospitals were established in China during the coronavirus disease 2019 (COVID-19) pandemic as a countermeasure to stop spread of disease. To our knowledge, no research has been conducted on mental health problems among patients hospitals. This study aimed determine prevalence and major influencing factors anxiety depressive symptoms COVID-19 admitted From February 23, 2020, 26, we obtained sociodemographic clinical characteristics information Jianghan Shelter Hospital...
Purpose.: We characterized the foveal avascular zone (FAZ) and parafoveal capillary network in healthy subjects using swept source OCT optical microangiography (OMAG). Methods.: acquired OMAG images of macula 19 eyes (13 individuals) a prototype laser OCT. En face retinal vasculature were generated for superficial deep inner layers (SRL/DRL) regions interest 250 (ROI-250) 500 (ROI-500) μm from FAZ border. Results.: The mean area (mm2) was 0.304 ± 0.132 SRL 0.486 0.162 DRL (P < 0.001). Mean...
To image subretinal neovascularization in proliferative macular telangiectasia Type 2 (MacTel2) using swept source optical coherence tomography based microangiography (OMAG).Patients with were enrolled a prospective, observational study known as the MacTel Project and evaluated high-speed 1,050 nm swept-source OCT prototype system. The OMAG algorithm generated en face flow images from three retinal layers, region bounded by outer retina Bruch membrane, choriocapillaris, remaining choroidal...
Advanced sequencing technologies have generated a plethora of data for many chromatin marks in multiple tissues and cell types, yet there is lack generalized tool optimal utility those data. A major challenge to quantitatively model the epigenetic dynamics across both genome types understanding their impacts on differential gene regulation disease. We introduce IDEAS, an integrative discriminative epigenome annotation system, jointly characterizing landscapes detecting regulatory regions....
Microtubules are essential for various cellular activities and β-tubulins the target of benzimidazole fungicides. However, evolution molecular mechanisms driving functional diversification in fungal tubulins not clear. In this study, we systematically identified tubulin genes from 59 representative fungi across kingdom. Phylogenetic analysis showed that α-/β-tubulin underwent multiple independent duplications losses different lineages formed distinct paralogous/orthologous clades. The last...
The spatial organization of chromatin in the nucleus has been implicated regulating gene expression. Maps high-frequency interactions between different segments have revealed topologically associating domains (TADs), within which most regulatory are thought to occur. TADs not homogeneous structural units but appear be organized into a hierarchy. We present OnTAD, an optimized nested TAD caller from Hi-C data, identify hierarchical TADs. OnTAD reveals new biological insights role levels,...
ABSTRACT Recent advent of 3C-based technologies such as Hi-C and ChIA-PET provides us an opportunity to explore chromatin interactions 3D genome organization in unprecedented scale resolution. However, it remains a challenge visualize interaction data due its size complexity. Here, we introduce the Genome Browser ( http://3dgenome.org ), which allows users conveniently both publicly available their own data. Users can also seamlessly integrate other “omics” sets, ChIP-Seq RNA-Seq for same...
Thousands of epigenomic data sets have been generated in the past decade, but it is difficult for researchers to effectively use all relevant their projects. Systematic integrative analysis can help meet this need, and VISION project was established
Quantitative comparison of epigenomic data across multiple cell types or experimental conditions is a promising way to understand the biological functions epigenetic modifications. However, differences in sequencing depth and signal-to-noise ratios from different experiments can hinder our ability identify real variation raw data. Proper normalization required prior analysis gain meaningful insights. Most existing methods for standardize signals by rescaling either background regions peak...
Abstract Electrochemical corrosion behavior of electroless Ni–P coating in NaCl and H 2 SO 4 solutions were studied by potentiodynamic polarization curves electrochemical impedance spectra techniques, as well the morphology was characterized. The results indicate that with about 25 µm is stable 30 days immersion solution. Although it corroded prolonged days, corrosive medium has not penetrated through coating. During concentration ranging from 5 to 10%, current density increased due...
To investigate the role of endoplasmic reticulum (ER) stress-mediated CRT/ERp57 complex expression underlying mechanism resistance to doxorubicin (DOX) in endometrial carcinoma (EC) vivo and vitro.The CRT, ERp57, p-PERK, eIF2α, p-eIF2α EC patients cells was detected by Western blots immunofluorescence assay. MTT assay used determine LC50 DOX cell viability. Apoptosis assayed using flow cytometer. The protein PERK, cleaved-caspase-8, CHOP were blot, VAMP-1, SNAP23 PERK knockdown siRNA and/or...
This study aimed to explore the prognostic factors and outcomes of patients with neuroendocrine tumors (NETs) cervix determine appropriate treatment.A single-institution retrospective analysis 172 NETs was performed based on new International Federation Gynecology Obstetrics (FIGO 2018) staging system.Among eligible patients, 161 were diagnosed small cell carcinoma (SCNEC), six large carcinoma, four typical carcinoid one SCNEC combined an atypical tumor. According FIGO 2018 guidelines, 31...
Abstract Chemical signal‐mediated biological communication is common within bacteria and between their hosts. Many plant‐associated respond to unknown plant compounds regulate bacterial gene expression. However, the nature of that mediate such interkingdom underlying mechanisms remain poorly characterized. Xanthomonas campestris pv. (Xcc) causes black rot disease on brassica vegetables. Xcc contains an orphan LuxR regulator (XccR) which senses a signal was validated be glucose by HPLC‐MS....
<h3>Introduction/Background</h3> Disitamab Vedotin (RC48) is a HER2-targeted ADC. A phase II, open-label, multicenter basket design study (NCT04965519) currently underway to evaluate the effectiveness and safety of RC48 monotherapy in treatment HER2-expressing gynecologic malignancies. <h3>Methodology</h3> The cervical cancer cohort includes patients with recurrent or metastatic who have progressed on at least 1L anti-tumor therapy HER2 IHC ≥1+. regimen consists administered dose 2 mg/kg...