A5051998023- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Nasal Surgery and Airway Studies
- Reconstructive Facial Surgery Techniques
- Cancer Genomics and Diagnostics
- Cleft Lip and Palate Research
- Reconstructive Surgery and Microvascular Techniques
- Genomics and Rare Diseases
- Head and Neck Anomalies
- Acute Myeloid Leukemia Research
- Tumors and Oncological Cases
- Ear Surgery and Otitis Media
- Head and Neck Cancer Studies
- Genomics and Phylogenetic Studies
- Oral and Maxillofacial Pathology
- Facial Nerve Paralysis Treatment and Research
- Mosquito-borne diseases and control
- Genomics and Chromatin Dynamics
- Congenital Ear and Nasal Anomalies
- Meningioma and schwannoma management
- Research on Leishmaniasis Studies
- Teratomas and Epidermoid Cysts
- Vascular Anomalies and Treatments
- Malaria Research and Control
Kaiser Permanente Orange County Irvine Medical Center
2023
University of California, Irvine
2023
ENT and Allergy
2023
Kaiser Permanente Anaheim Medical Center
2023
Penn State Milton S. Hershey Medical Center
2017-2022
Pennsylvania State University
2017-2022
Hershey (United States)
2019
Icahn School of Medicine at Mount Sinai
2015-2017
Mount Sinai Medical Center
2016
Yale University
2013
INTRODUCTION Mesoamerican nephropathy, also known as chronic kidney disease of unknown etiology, is widespread in Pacific coastal Central America. The cause the epidemic unknown, but may be linked to multiple factors, including diet well environmental and occupational exposures. As many 50% men some communities have nephropathy.
1. A prospective study of 239 Colles's fractures was made. 2. This indicates that all displaced should be reduced. 3. After reduction a below-elbow plaster used. 4. An above-elbow has no advantages and may have some disadvantages.
The development of surgical site infections (SSIs) can put the viability free tissue transfer reconstructions at risk, often resulting in considerable postoperative morbidity and prolonged hospitalization. Current antibiotic prophylactic guidelines suggest a first- or second-generation cephalosporin with metronidazole for clean-contaminated cases recommend clindamycin as an alternative choice penicillin-allergic patients. This study was designed to examine rates infection associated...
Circumsporozoite protein (CSP) of Plasmodium falciparum is a protective human malaria vaccine candidate. There an urgent need for models that can rapidly down-select novel CSP-based candidates. In the present study, mouse-mosquito transmission cycle transgenic berghei parasite stably expressing functional full-length P. CSP was optimized to consistently produce infective sporozoites protection studies. A minimal sporozoite challenge dose established, and defined as absence blood-stage...
Elevated body mass index (BMI) has been proposed as a risk factor for morbidity and mortality among patients undergoing surgery. Conversely, an elevated BMI may confer protective effect on perioperative morbidity.
Objective To determine if pharyngeal packs have an effect on postoperative pain and nausea vomiting in functional endoscopic sinus surgery (FESS). Study Design Forty‐six patients scheduled for routine were recruited into this study. The randomly allocated to or not packing prior surgery. Methods placement of during FESS is controversial. Theoretically, may prevent by preventing ingestion blood However, studies conclusively demonstrated be the case FESS. Pharyngeal been associated with...
ABSTRACT Antibodies against apical membrane antigen 1 (AMA1) inhibit invasion of Plasmodium merozoites into red cells, and a large number single nucleotide polymorphisms on AMA1 allow the parasite to escape inhibitory antibodies. The availability crystal structure makes it possible test protein engineering strategies develop monovalent broadly reactive vaccine. Previously, we showed that linear stretch polymorphic residues (amino acids 187 207), localized within C1 cluster domain 1,...
Abstract Structural variants can contribute to oncogenesis through a variety of mechanisms, yet, despite their importance, the identification structural in cancer genomes remains challenging. Here, we present an integrative framework for comprehensively identifying variation genomes. For first time, apply next-generation optical mapping, high-throughput chromosome conformation capture (Hi-C), and whole genome sequencing systematically detect SVs cells. Using this approach, identify...
Objectives/Hypothesis The goal of head and neck cancer surgery is the complete resection tumor with a cuff healthy tissue. A 5‐mm margin optimal but not always achievable in oropharynx. We aimed to identify consensus definition management close margins for human papilloma virus (HPV)‐associated oropharyngeal without other risk factors. Study Design Descriptive survey. Methods survey American Head Neck Society (AHNS) was conducted evaluate abovementioned objectives by presenting hypothetical...
To determine if otolaryngologists and audiologists of the American Academy Otolaryngology - Head Neck Surgery have noticed an increase in incidence sudden sensorineural hearing loss during coronavirus disease 2019 pandemic.A questionnaire was developed for purpose providing a cross-sectional descriptive analysis perceived association between pandemic loss.Of respondents, 63.0 per cent did not notice pandemic. There weak positive correlation patients identified with percentage reported by...
Abstract While genomic analysis of tumors has stimulated major advances in cancer diagnosis, prognosis and treatment, current methods fail to identify a large fraction somatic structural variants tumors. We have applied combination whole genome sequencing optical mapping number adult pediatric leukemia samples, which revealed each these samples not recognizable by tools analyses. developed computational determine those likely arose as mutations. The method identified 97% the previously...
Background The direct costs associated with different diagnostic algorithms to localize cerebrospinal fluid (CSF) rhinorrhea have not been described. Methods A decision‐tree analysis of imaging modalities used CSF was performed compare costs. primary outcome cost, which determined based on reimbursement data published by the Centers for Medicare and Medicaid Services in 2018. model parameterized after a literature review studies from 1990 2018 estimate sensitivity localization following...
Objectives Endoscopic endonasal anterior skull base surgery has expanding use in the pediatric population, but anatomy of patients can lead to limitations. This study aims characterize important anatomical implications using computed tomography (CT) scans. Design is designed as retrospective analysis. Setting The setting comprises tertiary academic medical center. Participants In total, 506 aged 0 18 who had undergone maxillofacial and or head CTs between 2009 2016 were involved. Methods...
Eustachian tube recanalization is a feasible procedure but additional studies are needed to determine its safety. closure can result from different etiologies and cause severe symptoms. Ureteral stents have appropriate shape pliability for placement long-term healing. Multidisciplinary team approach allows simultaneous endonasal otologic approaches.
Virtual surgical planning (VSP) has been applied to many aspects of head and neck reconstruction. The authors describe the use VSP create auricular templates in addition cartilage cutting suturing guides for microtia repair 2 patients with unilateral bilateral grade 3 microtia. Both had satisfactory aesthetic results. This technique allows increased precision, may decrease operative time, good cosmetic outcomes.
Eustachian tube balloon dilation (ETBD) has been Food and Drug Administration (FDA) approved for refractory dysfunction since 2016. While ETBD is generally seen as safe, the complication profile not well defined.The objective of this study was to utilize FDA manufacturer user facility device experience (MAUDE) database better assess adverse events (AE) related ETBD.This a multiinstitutional maintained by U.S. FDA. A analysis performed via collaboration multiple clinicians at tertiary...
Total laryngectomy (TL) results in complete abolition of nasal airflow, with notable pathologic alterations the intranasal mucosa, mucociliary clearance, and cycle. Despite these observed morphological changes, it remains unclear whether this subpopulation patients experiences clinically significant sinonasal disease. The goal study was to identify rhinosinusitis TL using radiographic imaging.An Institutional Review Board-approved retrospective review (January 2005-July 2017) identified 50...