A5076813915- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Angiogenesis and VEGF in Cancer
- RNA regulation and disease
- Intestinal and Peritoneal Adhesions
- Heat shock proteins research
- Adipose Tissue and Metabolism
- Reproductive Biology and Fertility
- Single-cell and spatial transcriptomics
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Energy, Environment, Economic Growth
- Ovarian function and disorders
- Reproductive tract infections research
- Pluripotent Stem Cells Research
- Tryptophan and brain disorders
- Gynecological conditions and treatments
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- TGF-β signaling in diseases
- China's Ethnic Minorities and Relations
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- CRISPR and Genetic Engineering
- T-cell and B-cell Immunology
Hubei University of Medicine
2012-2024
Taihe Hospital
2010-2024
Enzo Life Sciences (United States)
2020-2024
Nanchang Institute of Technology
2023
Jiangxi University of Finance and Economics
2021-2022
Jiangxi University of Technology
2021
China Mobile (China)
2021
Jining First People's Hospital
2017-2019
University of North Carolina at Chapel Hill
2003-2017
Merck & Co., Inc., Rahway, NJ, USA (United States)
2016-2017
Calcineurin, which binds to the Z-disc in cardiomyocytes via α-actinin, promotes cardiac hypertrophy response numerous pathologic stimuli. However, endogenous mechanisms regulating calcineurin activity muscle are not well understood. We demonstrate that a muscle-specific F-box protein called atrogin-1, or atrophy F-box, directly interacts with A and α-actinin-2 at of cardiomyocytes. Atrogin-1 associates Skp1, Cul1, Roc1 assemble an SCFatrogin-1 complex ubiquitin ligase activity. Expression...
Calcineurin, which binds to the Z-disc in cardiomyocytes via α-actinin, promotes cardiac hypertrophy response numerous pathologic stimuli. However, endogenous mechanisms regulating calcineurin activity muscle are not well understood. We demonstrate that a muscle-specific F-box protein called atrogin-1, or atrophy F-box, directly interacts with A and α-actinin-2 at of cardiomyocytes. Atrogin-1 associates Skp1, Cul1, Roc1 assemble an SCFatrogin-1 complex ubiquitin ligase activity. Expression...
Limitation of damage after ischemia and reperfusion injury to the myocardium remains an elusive clinical goal. Previous studies have suggested that molecular chaperones, which include members heat shock protein (Hsp) family, may cardioprotective effects, although protective role endogenous chaperones has not been well documented. CHIP (carboxyl terminus Hsp70-interacting protein) is a cochaperone/ubiquitin ligase integrates response stress at multiple levels. We tested CHIP(-/-) mice in vivo...
Endothelial cell migration is an important step during angiogenesis, and its dysregulation contributes to aberrant neovascularization. The bone morphogenetic proteins (BMPs) are potent stimulators of angiogenesis. Using microarray analyses, we find that myosin-X (Myo10) a BMP target gene. In endothelial cells, BMP6-induced Myo10 localizes in filopodia, BMP-dependent filopodial assembly decreases when expression reduced. Likewise, cellular alignment directional induced by BMP6 dependent....
Environmental, social, and governance (ESG) has become a buzzword in investment circles as ecological damage climate warming occur. ESG assessment is one of the important institutions green financial system, which plays significant part boosting corporate development. We use number patent applications citations to measure innovation analyze micro-green effects score system using panel fixed models, means that we explore impact scores on performance, specific mechanism this effect, asymmetry...
Abstract Aim Characterize Growth Differentiation Factor 15 (GDF15) as a secreted biomarker of the integrated stress response (ISR) within central nervous system (CNS). Methods We determined GDF15 levels utilizing in vitro and vivo neuronal systems wherein ISR was activated. Primarily, we used murine model vanishing white matter disease (VWMD), neurological driven by persistent CNS, to establish link between cerebrospinal fluid (CSF) gene expression signature CNS. also CSF VWM patients....
Protein quality control and metabolic homeostasis are integral to maintaining cardiac function during stress; however, little is known about if or how these systems interact. Here we demonstrate that C terminus of HSC70-interacting protein (CHIP), a regulator control, influences the response pressure overload by direct regulation catalytic α subunit AMPK. Induction in Chip-/- mice resulted robust hypertrophy decreased energy generation stemming from failure activate Mechanistically, CHIP...
Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, to assess its ability help quantify liver fibrosis in animal models. Materials Methods Biodistribution, pharmacokinetics, stability CM-101 rats were measured with mass spectrometry. Bile duct-ligated (BDL) sham-treated imaged 19 days after procedure by using 1.5-T clinical MR imaging unit. Mice treated carbon tetrachloride (CCl4) or vehicle two...
Abstract Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age‐related NAD decline. Whether the inhibition of increases lifespan is not known. Here, we show that inhibitor 78c healthspan naturally aged mice. In addition 10% increase median survival, improved exercise performance, endurance, function effects were different between sexes. Our study first investigate effect animals.
To investigate the effect of ascorbic acid [vitamin C (VC)] on liver damage parameters in lead-exposed mice, when given combination with thiamine B1 (VB(1))] at different concentrations.Sixty-six male mice were randomly assigned into 11 groups (n = 6). Mice Group I supplied only tap water as drinking water; II provided a containing 0.2% lead acetate; III-XI dose VC (140, 420, 1260 mg kg(-1) bw) and VB(1) (10, 30, 90 according to 3 x factorial design by oral gavages, along ingestion acetate....
To evaluate the efficacy and safety of oral ibrexafungerp (HS-10366) versus placebo in Chinese patients with vulvovaginal candidiasis (VVC).
Purpose: Antifungal drugs are used frequently in the treatment of vulvovaginal candidiasis (VVC), but have shown controversial results. In this study, we aimed to evaluate effectiveness different antifungal VVC and provide an evidence-based reference for clinical use. Methods: The published studies on (up April 2018) were retrieved from PubMed, Embase, Cochrane Library, ClinicalTrials.gov. We sifted through literature according Patients, Interventions, Comparisons Outcomes principle,...
Two novel trinuclear cluster-based coordination polymers {[M3(dip)(AcO)6]·(X)}n (1, M = Cu, X CH3OH; 2, Co, 2H2O) (dip is 2,6-Di-imidazol-1-yl-pyridine), have been synthesised and structurally determined by single crystal X-ray diffraction, element analysis. Crystallographic unit of 1 consists three Cu(II), six acetic ions, one dip ligand methanol molecule, which formed 1D chain through bridges. The further constructed 2-D network bridge 3-D π···π interaction. 2 Co(II), two water molecules....
Abstract Transient induction of pluripotent reprogramming factors has been reported to reverse some features aging in mammalian cells and tissues. However, the impact transient on somatic cell identity programs necessity individual pluripotency remain unknown. Here, we mapped trajectories young aged from multiple murine types using single transcriptomics address these questions. We found that restored youthful gene expression adipocytes mesenchymal stem but also temporarily suppressed...