A5102948104- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Biological and pharmacological studies of plants
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Phytochemical Studies and Bioactivities
- Bioactive natural compounds
- Phytochemical compounds biological activities
- Intraperitoneal and Appendiceal Malignancies
- Nail Diseases and Treatments
- Reproductive tract infections research
- Antifungal resistance and susceptibility
- Cancer Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Neurogenesis and neuroplasticity mechanisms
- RNA modifications and cancer
- Synthesis and Biological Evaluation
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Tryptophan and brain disorders
Cangzhou Central Hospital
2015-2024
To evaluate the efficacy and safety of oral ibrexafungerp (HS-10366) versus placebo in Chinese patients with vulvovaginal candidiasis (VVC).
The promoting effects of transcriptional factor Yin Yang 1 (YY1) have been confirmed in various tumors, however, its roles ovarian cancer (OC) progression are still unclear. Here, Kaplan-Meier Plotter analysis was used to determine the correlation between YY1 expression and survival OC patients. It found that negatively correlated with overall survival, progression-free post-progression Functional experiments indicated overexpression facilitated stemness cells, while knockdown reduced it....
Background: Cervical cancer (CC) is highly lethal and aggressive with an increasing trend of mortality for females. Molecular characterization-based methods hold great promise improving the diagnostic accuracy predicting treatment response. Methods: The mRNAs expression data CC patients cellular senescence-related genes were obtained from Cancer Genome Atlas (TCGA) CellAge databases, respectively. Differentially expressed (DEGs) senescence related between tumor normal tissues used Least...
Chamaejasmine is one of the major bioactive components Stellera chamaejasme L, which a Chinese traditional herbal medicine that has been used widely in treatment cancer. The aim this study to investigate potential effect chamaejasmine on cervical cancer cells and elucidate underlying mechanisms action. We first examined antitumor activity both vitro vivo. In following experiments with HeLa cells, cell apoptosis ultrastructure changes were assessed by flow cytometry transmission electron...
Ovarian cancer is one of the most common malignancies female reproductive system and deadliest gynecologic cancer. CXCR4 expressed in a variety malignant tumors such as breast, prostate, ovarian cancers. It also closely related to migration, invasion, metastasis tumor cells. Carbon nanotubes have great potential for targeted therapy tumors. CD44v6 not normal tissues but highly epithelial carcinoma. In present study, we applied small interfering RNA targeting gene clinical treatment...
Abstract Background To explore the effect and mechanism of delivery cisplatin (CDDP) resiquimod in nanomicelles for chemoimmunotherapy ovarian cancer vivo vitro. Methods Poly( l -glutamic acid)-graft-methoxypolyethylene glycols (PLG-g-mPEG) was used to carry preparation CDDP/resiquimod/PLG-g-mPEG. We determined loading content (LC) encapsulation efficiency (EE), then observed particle shape, size distribution zeta potential. In this study, we recruited 30 healthy adult participants isolated...
Endometrial cancer (EC) is a fatal gynecologic tumor. Bioinformatic tools are increasingly developed to screen out molecular targets related EC. Our study aimed identify stemness-related prognostic biomarkers for new therapeutic strategies in In this study, we explored the value of stem cells (CSCs), characterized by self-renewal and unlimited proliferation, its correlation with immune infiltrates Transcriptome somatic mutation profiles EC were downloaded from TCGA database. Based on their...
Abstract Cuproptosis is a new modality of cell death regulation that currently considered as cancer treatment strategy. However, cuproptosis-related lncRNAs (CRLs) have an unclear relationship with endometrial (EC). In this study, total 906 CRLs were identified, and 7 specific (AL807761.3, AF131215.7, AC008073.2, AC009229.1, CDKN2A.DT, LINC01615, LINC01166) selected to conduct risk model. Patients divided into high- low-risk groups according the median score. The prognosis high-risk group...