A5100565969- Soil Moisture and Remote Sensing
- Topic Modeling
- Natural Language Processing Techniques
- Hydrology and Watershed Management Studies
- Multimodal Machine Learning Applications
- Erythrocyte Function and Pathophysiology
- Heme Oxygenase-1 and Carbon Monoxide
- Cryospheric studies and observations
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Ion Transport and Channel Regulation
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Climate change and permafrost
- Porphyrin Metabolism and Disorders
- Meteorological Phenomena and Simulations
- Advanced Graph Neural Networks
- Generative Adversarial Networks and Image Synthesis
- Hydrological Forecasting Using AI
- Forest, Soil, and Plant Ecology in China
Nanjing University of Chinese Medicine
2019-2024
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2023-2024
Hohai University
2023-2024
Zhejiang International Studies University
2024
Zhejiang University
2024
University of Auckland
2022
Yan'an University
2022
Microsoft (United States)
2022
University of Notre Dame
2022
University of Washington
2022
Vascular endothelial growth factor (VEGF) is an angiogenic protein with neurotrophic and neuroprotective effects. Because VEGF promotes the proliferation of vascular cells, we examined possibility that it also stimulates neuronal precursors in murine cerebral cortical cultures adult rat brain vivo . (>10 ng/ml) stimulated 5-bromo-2′-deoxyuridine (BrdUrd) incorporation into cells expressed immature marker proteins increased cell number by 20–30%. Cultured labeled BrdUrd VEGFR2/Flk-1, but...
Globins are oxygen-binding heme proteins present in bacteria, protists, fungi, plants, and animals. Their functions have diverged widely evolution, include binding, transport, scavenging, detoxification, sensing of gases like oxygen, nitric oxide, carbon monoxide. Neuroglobin (Ngb) is a recently discovered monomeric globin with high affinity for oxygen preferential localization to vertebrate brain. No function Ngb known, but its expression cerebral neurons suggest role neuronal responses...
Insulin has a narrow therapeutic index, reflected in small margin between dose that achieves good glycemic control and one causes hypoglycemia. Once injected, the clearance of exogenous insulin is invariant regardless blood glucose, aggravating potential to cause We sought create “smart” insulin, can alter hence action response mitigating risk for The approach added saccharide units analogs with affinity both receptor (IR) mannose C-type 1 (MR), which functions clear endogenous mannosylated...
Graph convolutional network (GCN) outputs powerful representation by considering the structure information of data to conduct learning, but its robustness is sensitive quality both feature matrix and initial graph. In this article, we propose a novel multigraph fusion method produce high-quality graph low-dimensional space original high-dimensional for GCN model. Specifically, proposed first extracts common complementary among multiple local graphs obtain unified graph, which then fused with...
Neurogenesis, or the production of new neurons, is regulated by physiological and pathological processes including aging, stress, brain injury. Many mitogenic trophic factors that regulate proliferation nonneuronal cells are also involved in neurogenesis. These include vascular endothelial cell growth factor (VEGF), which stimulates incorporation bromodeoxyuridine (BrdU) into neuronal precursor vitro adult rat vivo. Using BrdU labeling as an index proliferation, we found neuroproliferative...
We investigated the role of mitogen-activated protein kinase (MAPK) pathways in hypoxic neuronal injury using primary cultures from murine cerebral cortex. Hypoxia caused death approximately 50% neurons at 16 h and 65% 24 h. This was associated with phospho-activation MAPK/extracellular signal-regulated (ERK) MEK1/2 its downstream target ERK1/2, but not p38 MAPK or c-Jun N-terminal (JNK), as detected by western blotting. The inhibitor, PD98059, increased cultures, suggesting that promotes...
Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, to assess its ability help quantify liver fibrosis in animal models. Materials Methods Biodistribution, pharmacokinetics, stability CM-101 rats were measured with mass spectrometry. Bile duct-ligated (BDL) sham-treated imaged 19 days after procedure by using 1.5-T clinical MR imaging unit. Mice treated carbon tetrachloride (CCl4) or vehicle two...
Fibrosis, or the accumulation of extracellular matrix, is a common feature many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, as well kidney and liver fibrosis models. Transcriptome analyses reveal that genes involved in fatty acid oxidation are significantly perturbed. Furthermore, mitochondrial dysfunction acylcarnitine found fibrotic tissues. Substantial downregulation PGC1α gene...
Extreme precipitation (EP) events have intensified in arid and semi-arid regions due to climate change. Understanding the causal mechanisms driving EP at sub-seasonal timescale is crucial for improving prediction accuracy extending forecast lead times. This study investigates characteristics Northwest China (ASRNC) reveals through a composite analysis that associated with specific atmospheric circulation patterns, including anomalous upper-level thermal lower-level dynamic conditions....
Bombesin receptor subtype-3 (BRS-3) regulates energy homeostasis, and BRS-3 agonism is being explored as a possible therapy for obesity. Here we study the role of in regulation glucose-stimulated insulin secretion (GSIS) glucose homeostasis. We quantified mRNA pancreatic islets from multiple species examined acute effects Bag-1, selective agonist, on GSIS mouse, rat, human islets, oral tolerance mice. highly expressed human, rhesus, dog (but not rat) rodent insulinoma cell lines (INS-1 832/3...
GPR40 and GPR120 are fatty acid sensors that play important roles in glucose energy homeostasis. potentiates glucose-dependent insulin secretion demonstrated clinical studies robust lowering type 2 diabetes. improves sensitivity rodents, albeit its mechanism of action is not fully understood. Here, we postulated the antidiabetic efficacy could be enhanced by coactivating GPR120. A combination agonists db/db mice, as well a single molecule with dual agonist activities, achieved superior...
Abstract Multiple integrins have been implicated in modulating renal function. Modulation of integrin function can lead to pathophysiological processes associated with diabetic nephropathy such as alterations the glomerular filtration barrier and kidney fibrosis. The complexity these changes implies that multiple subtypes might need be targeted ameliorate progression disease. To address this hypothesis, we investigated effects MK ‐0429, a compound was originally developed an α v β 3...
Endoglin (CD105) is a membrane glycoprotein that mutated in hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) and shows increased expression proliferating endothelial cells during angiogenesis.We investigated the effect of hypoxia on endoglin murine cerebral microvascular (bEND.3) vitro possible involvement mitogen-activated protein kinase (MAPK) pathways.Hypoxia mRNA bEND.3 cells, which was associated with phosphoactivation extracellular signal-related (ERK), p38 MAPK, Jun...
Purpose To confirm the relationship between plasma osteopontin (OPN) levels and treatment outcomes in head neck squamous cell carcinoma (HNSCC) patients an expanded study. Patients Methods One hundred forty with newly diagnosed HNSCC were enrolled onto this study, 54 previously reported 86 new patients. Pretreatment OPN assessed all by enzyme-linked immunosorbent assay method. correlated to group of Detailed analyses also performed on tumor control rate, event-free survival (EFS),...
Pancreatic cancer is one of the most aggressive cancers with poor prognosis and a low 5-year survival rate. The family P21-activated kinases (PAKs) appears to modulate many signaling pathways that contribute pancreatic carcinogenesis. In this work, we demonstrated PAK1 critical regulator in cell growth. PAK1-targeted inhibition therefore new potential therapeutic strategy for cancer. Our small molecule screening identified relatively specific inhibitor, CP734. Pharmacological biochemical...
The renal outer medullary potassium channel (ROMK, KCNJ1) mediates recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in loop of Henle secretion at cortical collecting duct. Human genetic studies indicate that ROMK homozygous loss-of-function mutations cause type II Bartter syndrome, featuring polyuria, salt wasting, hypotension; humans heterozygous for identified Framingham Heart Study have reduced blood pressure. null mice recapitulate many features...
Metabolic dysregulation and mitochondrial dysfunction are important features of acute chronic tissue injury across species, human genetics preclinical data suggest that the master metabolic regulator 5'-adenosine monophosphate-activated protein kinase (AMPK) may be an effective therapeutic target for kidney disease (CKD). We have recently disclosed a pan-AMPK activator, MK-8722, was shown to beneficial effects in models. In this study we investigated MK-8722 progressive rat model diabetic...
The renal outer medullary potassium (ROMK) channel mediates recycling and facilitates sodium reabsorption through the Na+/K+/2Cl- cotransporter in loop of Henle secretion at cortical collecting duct. Evidence from phenotype humans rodents with functional ROMK deficiency supports contention that selective inhibitors (ROMKi) will represent a novel diuretic potential therapeutic benefit for hypertension. ROMKi have recently been synthesized by Merck & Co, Inc. present studies were designed to...