A5026221139- Hepatitis B Virus Studies
- Traditional Chinese Medicine Studies
- Computational Drug Discovery Methods
- Rheumatoid Arthritis Research and Therapies
- Retinal Imaging and Analysis
- Pharmacological Effects of Natural Compounds
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Pharmaceutical studies and practices
- Ion Channels and Receptors
- Natural Compounds in Disease Treatment
- Flavonoids in Medical Research
- Chronic Lymphocytic Leukemia Research
- Cholinesterase and Neurodegenerative Diseases
- HIV/AIDS drug development and treatment
- Biotin and Related Studies
- HIV-related health complications and treatments
- Osteoarthritis Treatment and Mechanisms
- Curcumin's Biomedical Applications
- Hepatitis C virus research
- Inflammasome and immune disorders
- Cerebrovascular and Carotid Artery Diseases
- Biological Activity of Diterpenoids and Biflavonoids
- HIV Research and Treatment
- Cancer Mechanisms and Therapy
Second Hospital of Anhui Medical University
2019-2025
Anhui Medical University
2019-2025
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Guangdong Pharmaceutical University
2014
Cardiovascular diseases (CVDs) remain the foremost cause of mortality globally, emphasizing imperative for early detection to improve patient outcomes and mitigate healthcare burdens. Carotid intima-media thickness (CIMT) serves as a well-established predictive marker atherosclerosis cardiovascular risk assessment. Fundus imaging offers non-invasive modality investigate microvascular pathology systemic vascular health. However, paucity high-quality, publicly available datasets linking fundus...
Abstract Articular cartilage damage and chondrocyte apoptosis are common features of rheumatoid arthritis osteoarthritis. Recently, curcumin has been reported to exhibit protective effects on degeneration in articular diseases. However, the mechanisms injury remain be elucidated. The aim present study is investigate chondroprotective interleukin‐1β (IL‐1β)‐induced vitro. results revealed that IL‐1β decreased cell viability induced primary chondrocytes. Curcumin pretreatment reduced...
To assess the effectiveness of violate oil from Blumea Balsamifera (L.) DC. leaves (BB oil) on wound healing in mice. Undiluted BB and its diluted solutions with olive to 1/5 1/10 yield oil1/5 oil1/10 were applied wounded skin before conditions assessed by rate, histopathology, contents collagen, hydroxyproline, Neuropeptide Substance P (SP). All above results compared efficacies control, pure oil, basic fibroblast growth factor (BFGF), cream Jing Wan Hong (JWH). improved contraction...
Objective To develop and validate an artificial intelligence diagnostic model based on fundus images for predicting Carotid Intima-Media Thickness (CIMT) in individuals with Type 2 Diabetes Mellitus (T2DM). Methods In total, 1236 patients T2DM who had both retinal CIMT ultrasound records within a single hospital stay were enrolled. Data divided into normal thickened groups sent to eight deep learning models: convolutional neural networks of the models all ResNet or ResNeXt. Their encoder...
Traditional Chinese medicine has specific effect on some chronic diseases in clinic, especially rheumatic diseases. Tripterygium wilfordii Hook (TWH) is a traditional commonly used the treatment of rheumatoid arthritis (RA); unique therapeutic been confirmed by large number research papers. TWH many compounds that lead to its active compounds. However, potential targets and pharmacological molecular mechanism action are not entirely clear. Therefore, network pharmacology approach needed...
Yiganling (YGL) capsule is a traditional Chinese medicine preparation consisting of eight herbs that has been clinically proven to have favorable treatment effect on Hepatitis B (HB). However, due its multiple targets and multi-pharmacological effects, the mechanisms YGL in HB are unknown.First, chemical constituents capsules were obtained from database, constructed. Second, active compounds screened by ADME model. The target fishing model was used screen corresponding construct compound...
Abstract Lopinavir/ritonavir is an important protease inhibitor for treating HIV‐1 infection in patients aged >2 years combination with other antiretrovirals. The antiviral activity of lopinavir/ritonavir vivo mainly derived from lopinavir, while ritonavir improves the bioavailability lopinavir. This study compared bioequivalence and safety 2 (200/50 mg) formulations under fasted fed conditions healthy Chinese volunteers pharmacokinetic parameters lopinavir ritonavir. A randomized,...
Abstract Background: Shenlian Capsule is a Chinese medicine compound approved by the China Food and Drug Administration (CFDA) for treatment of advanced non-small cell lung cancer(NSCLC). However, due to its complex constituents, cause effective active compounds main action mechanisms treating diseases are still not fully clear. The purpose this work explore ingredients NSCLC through system pharmacological approach. Methods: First, database chemical composition was constructed retrieving...