A5103008385- Salivary Gland Disorders and Functions
- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Systemic Lupus Erythematosus Research
- Traditional Chinese Medicine Analysis
- Genetic Associations and Epidemiology
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Gut microbiota and health
- Tryptophan and brain disorders
- Adenosine and Purinergic Signaling
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Health, Environment, Cognitive Aging
- Inflammasome and immune disorders
- Health, psychology, and well-being
- Signaling Pathways in Disease
Zhejiang Chinese Medical University
2023-2025
Sichuan University
2022
Type 1 interferon (IFN-I)-related genes play a critical role in Sjögren's syndrome (SS). However, study on its and impact peripheral blood B cells of SS is limited. This investigated gene expression epigenetic changes IFI44L, analyzing correlation with disease activity clinical indicators. Differentially expressed (DEGs) were identified from the GSE199868 dataset, while IFN-I-related collected GeneCards. Intersection analysis revealed DEGs SS. ClueGO, Kyoto Encyclopedia Genes Genomes (KEGG)...
Although immune checkpoint inhibitors (ICIs) provide unprecedented survival improvement for patients with advanced non-small cell lung cancer (NSCLC), disease progression inevitably occurs. After ICIs failure, limited data exist on whether ICI-based treatment beyond (TBP) may be beneficial to NSCLC. This retrospective study aimed evaluate the efficacy of this approach in NSCLC and identify potential factors.Patients stage IV who received after failure prior PD-1/PD-L1 inhibitor treatments...
Purpose: Sjogren's Syndrome (SS) is a systemic autoimmune disease primarily characterized by dysfunction of the exocrine glands. Research into etiology and pathogenesis salivary glands (SG) inflammation SS very limited. The aim this study was to identify potential pyroptosis-related genes in SG through bioinformatics analysis validation SS. Methods: GSE157159 dataset GSE159574 were downloaded from Gene Expression Omnibus (GEO). Differentially Expressed Genes (DEGs) used screen DEGs non-SS...
The purpose was to identify shared immune cells and co-disease genes in chronic heart failure (HF) systemic lupus erythematosus (SLE), as well explore the potential mechanisms of action between HF SLE.A collection peripheral blood mononuclear (PBMCs) from ten patients with SLE normal controls (NC) used for transcriptome sequencing. Differentially expressed (DEGs) analysis, enrichment infiltration weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) machine...
Numerous observational and retrospective studies have demonstrated an association between Autoimmune Thyroiditis (AIT) various systemic Diseases (AIDs). However, the causal relationship them remains uncertain. This study aims to investigate link AIT diverse types of AIDs utilizing Mendelian Randomization (MR) method.
Life's Essentials 8 (LE8) is a new indicator developed by the American Heart Association to assess cardiovascular health, including diet, physical activity, nicotine exposure, sleep body mass index, blood lipids, glucose and pressure. And more studies have shown that this index can evaluate other diseases, such as chronic kidney disease, abdominal aortic calcification so on. However, there no relevant study association between LE8 psoriasis. The purpose of was investigate relationship...
Purpose: To apply bioinformatics for the identification of potential genes associated with Huo Xin Pill (HXP), a traditional Chinese medicine (TCM) used treatment acute myocardial infarction AMI).Methods: Mouse AMI expression profile dataset GSE153485 and HXP-treated mouse GSE147365 were downloaded from GEO database. Then, R software was to screen differentially-expressed in AMI. Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses, Venn diagrams,...
Heart failure is a serious complication after acute myocardial infarction (AMI). It crucial to investigate the mechanism of action empagliflozin in treatment heart failure.A total 20 wild type (WT) male C57BL6/J mice were used establish model and randomly divided into 2 groups: group control group. The was treated with empagliflozin, placebo. After 8 weeks treatment, mouse tissues collected for next generation sequencing. Bioinformatics methods screen key genes. Finally, correlation between...