Type 1 interferon (IFN-I)-related genes play a critical role in Sjögren's syndrome (SS). However, study on its and impact peripheral blood B cells of SS is limited. This investigated gene expression epigenetic changes IFI44L, analyzing correlation with disease activity clinical indicators. Differentially expressed (DEGs) were identified from the GSE199868 dataset, while IFN-I-related collected GeneCards. Intersection analysis revealed DEGs SS. ClueGO, Kyoto Encyclopedia Genes Genomes (KEGG)...

This study aimed to explore the mode of action Yiqiyangyinquyu prescription (YP) against Sjögren's syndrome (SS) by combining network pharmacology with molecular docking techniques. YP's active components and target proteins were identified using BATMAN-traditional Chinese medicine database. Concurrently, targets associated SS extracted from databases, including Genecards, Online Mendelian Inheritance in Man, Therapeutic Target Database. The standard then imported into STRING database...

Journal Article Accepted manuscript Comment on: Systemic lupus erythematosus patients have unique changes in serum metabolic profiles across age associated with cardiometabolic risk Get access Liying Chen, Chen The Second Affiliated College of Zhejiang Chinese Medical University, Hangzhou, China Search for other works by this author Oxford Academic PubMed Google Scholar Xvfeng Zhang, Zhang Xinchang Wang Department Rheumatology, Hospital Corresponding author: Wang, Province, 310005, P.R....

Systemic lupus erythematosus is a heterogeneous autoimmune disease in which skin involvement common manifestation. It currently thought that the photosensitivity of SLE associated with anti-SSA antibodies. This study aimed to expand current state knowledge surrounding molecular pathophysiology through Serum metabolomics analysis.The serum metabolites 23 cases skin-involved (SI) group, 14 no SI (NSI) and 30 healthy controls (HC) were analyzed by using UPLC-MS/MS technology, subgroup analysis...

Purpose: Sjogren's Syndrome (SS) is a systemic autoimmune disease primarily characterized by dysfunction of the exocrine glands. Research into etiology and pathogenesis salivary glands (SG) inflammation SS very limited. The aim this study was to identify potential pyroptosis-related genes in SG through bioinformatics analysis validation SS. Methods: GSE157159 dataset GSE159574 were downloaded from Gene Expression Omnibus (GEO). Differentially Expressed Genes (DEGs) used screen DEGs non-SS...

Background: Primary Sjögren's syndrome (pSS) is an autoimmune disease with lymphocytic infiltration of the salivary and lachrymal glands, whose present disease-specific objective indicators are few have shortcomings that should be addressed. An integrated analysis sequencing data from different cohorts has potential to unveil novel biomarkers in pSS. Methods: We identified 3 GEO datasets, including gene expression minor gland (MSG) biopsy samples 49 patients pSS 31 non-pSS whole blood cells...

Abstract Aim Sjögren syndrome (SS) is a slowly progressive, inflammatory, autoimmune disease. The aim of this study was to construct the DNA methylation profiles whole blood SS patients and healthy controls (HC), explore role differentially methylated genes in pathogenesis Methods Whole‐genome bisulfite sequencing performed on three four HC. biological function associated with regions (DMRs) investigated using Gene Ontology functional analysis Kyoto Encyclopedia Genes Genomes pathway...

Neuropsychiatric lupus (NPSLE) is one of the important manifestations systemic erythematosus. Previous studies mainly focused on disruption blood-brain barrier and production brain-reactive autoantibodies, However, there no comprehensive lipidomic analysis in NPSLE. Therefore, this research evaluated hippocampus liver NPSLE mice with mood disorders, to explore influence liver-brain axis disease.MRL/lpr MRL/mpj were respectively used as control groups. Behavioral tests disease characteristics...

Abstract. Electromagnetic exploration, characterized by its low cost, wide applicability, and high operational efficiency, finds extensive applications in fields such as oil gas mineral prospecting, engineering geology. Traditional controlled-source electromagnetic detection methods are typically confined to operating frequencies below 250 kHz, resulting insufficient accuracy for shallow intermediate-depth thereby constraining their performance high-resolution imaging. To address these...

This study assesses the diluted Schirmer method's effectiveness in collecting tears from dry eye syndrome patients, aiming to identify most suitable tear collection technique for them.

Numerous observational and retrospective studies have demonstrated an association between Autoimmune Thyroiditis (AIT) various systemic Diseases (AIDs). However, the causal relationship them remains uncertain. This study aims to investigate link AIT diverse types of AIDs utilizing Mendelian Randomization (MR) method.

Abstract. Electromagnetic exploration, characterized by its low cost, wide applicability, and high operational efficiency, finds extensive applications in fields such as oil gas mineral prospecting, engineering geology. Traditional controlled-source electromagnetic detection methods are typically confined to operating frequencies below 250 kHz, resulting insufficient accuracy for shallow- intermediate-depth thereby constraining their performance high-resolution imaging. To address these...

Life's Essentials 8 (LE8) is a new indicator developed by the American Heart Association to assess cardiovascular health, including diet, physical activity, nicotine exposure, sleep body mass index, blood lipids, glucose and pressure. And more studies have shown that this index can evaluate other diseases, such as chronic kidney disease, abdominal aortic calcification so on. However, there no relevant study association between LE8 psoriasis. The purpose of was investigate relationship...

Abstract Objective Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by unpredictable flares. This study aimed to develop novel proteomics-based risk prediction model specifically for Asian SLE populations enhance personalized management and early intervention. Methods A longitudinal cohort was conducted over 48 weeks, including 139 patients monitored every 12 weeks. Patients were classified into flare (n = 53) non-flare 86) groups. Baseline plasma samples...

The coexistence of Sjögren's syndrome (SS) and Hashimoto thyroiditis (HT) has been confirmed, but the common mechanism its co-occurrence remains unknown. This study aims to further explore underlying biomarkers for SS HT. Gene Expression Omnibus databases were used obtain gene expression profiles (GSE127952 GSE23117) HT (GSE29315 GSE138198). Following identifying HT's shared differentially expressed genes, functional annotation, protein-protein interaction network creation, module assembly...