A5086965995- Face and Expression Recognition
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Drug Transport and Resistance Mechanisms
- Breast Cancer Treatment Studies
- Text and Document Classification Technologies
- Kruppel-like factors research
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Connective Tissue Growth Factor Research
- Remote Sensing and Land Use
- Cancer and Skin Lesions
- Wnt/β-catenin signaling in development and cancer
- Liver Disease Diagnosis and Treatment
- Sphingolipid Metabolism and Signaling
- Remote-Sensing Image Classification
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Imbalanced Data Classification Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Clustering Algorithms Research
- Single-cell and spatial transcriptomics
- Extracellular vesicles in disease
Jilin Agricultural University
2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xiyuan Hospital
2024
Midea Group (China)
2024
Inner Mongolia University
2022-2024
Nanjing University of Chinese Medicine
2021-2023
Ocean University of China
2020-2022
Sun Yat-sen University
2013-2021
Sun Yat-sen University Cancer Center
2013-2021
Cold tumor microenvironment (TME) marked with low effector T cell infiltration leads to weak response immune checkpoint inhibitor (ICI) treatment. Thus, switching cold hot TME is critical improve potent ICI therapy. Previously, we reported extracellular vesicle (EV)-like ginseng-derived nanoparticles (GDNPs) that were isolated from Panax ginseng C.A. Mey and can alter M2 polarization delay the B16F10 progression. However, more common challenging in real world. Here, explored a combinatorial...
Clinically, activated EGFR mutation associated chemo-drugs resistance has severely threaten NSCLC patients. Nanoparticle based small interfering RNA (siRNA) therapy representing another promising alternative by silencing specific gene while still suffered from charge toxicity, strong immunogenicity and poor targetability. Herein, we reported a novel EGFR-mutant relying on edible cation-free kiwi-derived extracellular vesicles (KEVs), which showed sevenfold enhancement of safe dosage compared...
The present study assessed the effects of tankyrase (TNKS) small molecule inhibitor XAV939 on proliferation and migration lung adenocarcinoma A549 cells possible underlying mechanism. To do this, association between TNKS WNT/β‑catenin signaling pathway in acinar was investigated. Immunohistochemistry performed, which demonstrated that TNKS, β‑catenin Myc proto‑oncogene protein (c‑Myc) proteins are positively expressed tissue; this expression significantly higher than normal adjacent...
Different crops, as well the same crop at different growth stages, display distinct spectral and spatial characteristics in hyperspectral images (HSIs) due to variations their chemical composition structural features. However, narrow bandwidth closely spaced channels of HSIs result significant data redundancy, posing challenges identification classification. Therefore, dimensionality reduction is crucial. Band selection a widely used method for reducing has been extensively applied research...
Abstract Background Lines of evidence indicated that, immune checkpoints (ICs) inhibitors enhanced T cell response to exert anti-tumor effects. However, exhaustion has been so far a major obstacle antitumor immunotherapy in colorectal cancer patients. Our previous studies showed that ginseng-derived nanoparticles (GDNPs) inhibited the growth various tumors by reprograming tumor-associated macrophages (TAMs) and downregulated ICs expression on cells tumor microenvironment (TME), but...
Abstract Background miR-92b is a carcinogenic miRNA that has great potential as biomarker for disease prognosis, diagnosis, and treatment in the clinic. It of significance to analyse relationship between clinicopathological characteristics cancer patients. This paper aimed investigate expression levels clinical values miR-92b-3p breast (BC). Methods Altogether, 112 female BC patients who were treated our hospital included study group, 108 healthy women came physical examinations control...
Background: The purpose of this study was to investigate the effect non-alcoholic fatty liver disease (NAFLD) on risk synchronous colorectal metastasis (synCRLM). Methods: A retrospective analysis performed 451 consecutive patients with newly diagnosed cancer (CRC) from January 2014 2019. According presence NAFLD, CRC were divided into two groups, NAFLD group (60 cases) and control (391 cases). clinicopathological features prevalence synCRLM between groups compared. Logistic regression used...
Background. The incidence and mortality of breast cancer in the world remain high. function important role miR-451 miR-506 a series cancers have been proved. purpose this research was to explore clinical diagnosis prognostic significance expression cancer. Methods. Quantitative real-time polymerase chain reaction (qRT-PCR) applied detect serum tissues. relationship with parameters determined by chi-square test. Receiver operating characteristics (ROC) analysis conducted evaluate diagnostic...
Abstract TNKS is a new target for the treatment of lung adenocarcinoma, synergistic effects TCM compound Xiaoyan decoction and inhibitor E7449 in intervention on were investigated, possible underlying mechanisms involved clarified. Immunohistochemistry was used to analyse expression tumour tissues. The impact targeting cell growth, invasion, apoptosis, key genes signalling pathways investigated cells by Western blotting, rescue experiments, colony formation assays, flow cytometry label‐free...
Abstract Objective To conduct an analysis using propensity score methods, exploring the association between a prolonged second stage (>3 h) and risk of postpartum hemorrhage (PPH) in diverse population. Methods We conducted prospective cohort study involving nullipara with epidural anesthesia vaginal delivery, aged ≥18 years, presenting cephalically, gestational age (GA) ≥24 weeks at tertiary maternity hospital China ( chictr.org.cn identifier: ChiCTR2200063094). Women undergoing...
Machine learning is widely recognized as a promising data-driven modeling technique for the model-based control and optimization of building energy systems. However, generalizability models often faces significant challenges, available training data from operations usually only covers limited range working conditions. Active can proactively test unseen informative conditions to enrich set by adding new samples, leading improved generalization performance models. A novel distance information...
Probiotics and plant extracts have been used to prevent the development of type 2 diabetes mellitus (T2DM). The study aimed explore effect interaction between potential probiotics bitter gourd extract (BGE) or mulberry leaf (MLE) on T2DM.Potential were tested for their gastrointestinal tract viability growth situation combined with BGE MLE in vitro. model was constructed C57BL/6 mice, mechanism regulating blood glucose verified. Hematoxylin-eosin staining (HE), gas chromatography (GC),...
In recent years, due to the rapid development of Chinese textile industry, domestic demand for cotton increases sharply. Conversely, plantation area increasingly dwindled, resulting in constant rise imports. China, as a great importer, has classified manually grades long time, which not only results consumption labor and financial resources, but also leads some mistakes generated b s subjective evaluation. This paper presents method automatic classification different appearance grades. Based...
We report a rare case of gastric cancer with liver metastasis in patient whose condition improved the combination use lenvatinib and camrelizumab. A 53-year-old man was admitted to hospital for abdominal pain. After an enhanced CT scan his abdomen, it found that he had multiple occupancy. Gastroscopic biopsies supported clinical diagnosis stage IV cancer. Next-generation sequencing technology (NGS) testing indicated tumor mutational burden (TMB) tissue stomach samples were high. The first...
Resistance to 5-FU reduces its clinical efficacy for the treatment of colorectal cancer. Sphingosine-1-phosphate receptor 2 (S1PR2) has emerged as a potential target reverse 5-FU-resistance by inhibiting expression dihydropyrimidine dehydrogenase (DPD). In this study, 38 novel S1PR2 antagonists based on aryl urea structure were designed and synthesized, structure–activity relationship was investigated binding assay. Representative compound 43 potently interacts with KD value 0.73 nM. It...
Organizing data into reasonable groupings is one of the most fundamental tasks in machine learning. This paper proposes an improved version multiple flat projections clustering (MFPC) by replacing L2 norm with L1 for cross-manifold problem, called (L1MFPC). The presented L1MFPC reduces sensitivity MFPC to outliers and enhances its ability handle noisy data. Specifically, L1MFPC, samples are compressed a unit hypercube that conforms characteristics. Comprehensive consideration given...
Imbalanced classification problems are of great significance in life, and there have been many methods to deal with them, e.g. eXtreme Gradient Boosting (XGBoost), Logistic Regression (LR), Decision Trees (DT), Support Vector Machine (SVM). Recently, a novel Generalization-Memorization (GMM) was proposed maintain good generalization ability zero empirical for binary classification. This paper proposes Weighted Generalization Memorization (WGMM) imbalanced By improving the memory cost...