A5100694566- HIV/AIDS drug development and treatment
- Malaria Research and Control
- Nanoparticle-Based Drug Delivery
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Computational Drug Discovery Methods
- HIV-related health complications and treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Drug Transport and Resistance Mechanisms
- RNA Interference and Gene Delivery
- Neurological Disease Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- Cytomegalovirus and herpesvirus research
- Synthesis and Biological Evaluation
- Medical Research and Treatments
- Human Pose and Action Recognition
- Subtitles and Audiovisual Media
- Multimodal Machine Learning Applications
- Pharmacological Effects of Natural Compounds
- Prenatal Screening and Diagnostics
- Dendrimers and Hyperbranched Polymers
- Berberine and alkaloids research
- Folate and B Vitamins Research
- Cancer Mechanisms and Therapy
- Crystallization and Solubility Studies
Shanxi Medical University
2011-2024
Henan Provincial People's Hospital
2014-2024
Beijing VDJBio (China)
2024
Beijing Polytechnic
2023
Ministry of Public Security of the People's Republic of China
2023
Massey University
2021
Shaanxi Provincial People's Hospital
2021
Chengdu University of Traditional Chinese Medicine
2019
Liaocheng People's Hospital
2018
South China University of Technology
2017
Oral preexposure prophylaxis (PrEP) trials report disparate efficacy attributed to variable adherence. HPTN 066 was conducted establish objective, quantitative benchmarks for discrete, regular levels of adherence using directly observed dosing tenofovir (TFV) disoproxil fumarate (TDF)/emtricitabine (FTC). Healthy, HIV-uninfected men and women were randomized one four oral regimens fixed-dose TDF 300 mg/FTC 200 mg tablet 5 weeks with all doses observed: weekly (one/week), twice (two/week),...
Hydrogen generation via photocatalysis-driven water splitting provides a convenient approach to turn solar energy into chemical fuel. The development of photocatalysis system that can effectively harvest visible light for hydrogen is an essential task in order utilize this technology. Herein, kind cadmium free Zn-Ag-In-S (ZAIS) colloidal quantum dots (CQDs) shows remarkably photocatalytic efficiency the region developed. More importantly, nanocomposite based on combination 0D ZAIS CQDs and...
ABSTRACT Tenofovir gel (1%) is being developed as a microbicide for the prevention of human immunodeficiency virus (HIV) infection and has been shown to reduce transmission women by 39%. The also prevents in macaques when applied intravaginally or intrarectally prior challenge with simian-human (SHIV), but very little pharmacokinetic information available help extrapolate data humans thus inform future development activities. We have determined pharmacokinetics tenofovir following...
A sensitively electrochemical metronidazole sensor basing on a Pt nanospheres/polyfurfural modified glassy carbon electrode.
To investigate the intraindividual pharmacokinetics (PKs) of total (protein bound plus unbound) and unbound lopinavir/ritonavir (LPV/RTV) to assess whether pediatric formulation (100 mg/25 mg) can overcome any pregnancy-associated changes.
Purpose. To determine the efficacy and safety of preoperative intravitreal conbercept (IVC) injection before vitrectomy for proliferative diabetic retinopathy (PDR). Methods. 107 eyes 88 patients that underwent pars plana (PPV) active PDR were enrolled. All assigned randomly to either IVC group or control group. Follow-up examinations performed three months after surgery. The primary bioactivity measures severity intraoperative bleeding, incidence early late recurrent VH, vitreous clear-up...
Background: Launched in March 2019, the National Centralized Drug Procurement (NCDP) initiative aimed to optimize drug utilization framework public healthcare facilities. Following integration of Non-Vitamin K Antagonist Oral Anticoagulants (NOACs) into procurement catalog, establishments Suining swiftly transitioned widespread adoption NOACs, beginning 1 2020. Objective: This study aims comprehensively assess impact NCDP policy on efficacy anticoagulation therapy, patient medication...
Background Maternal deaths occur mostly in developing countries and the majority of them are preventable. This study analyzes changes maternal mortality related causes Henan Province, China, between 1996 2009, an attempt to provide a reliable basis for introducing effective interventions reduce ratio (MMR), part fifth Millennium Development Goal. Methods Findings population-based survey Province was carried out from 2009. Basic information obtained health care network women children vital...
Abstract It is urgent to develop new antimalarial drugs with good therapeutic effects address the emergence of drug resistance. Here, artelinic acid-choline derivative (AD) was synthesized by dehydration reaction and esterification reaction, aimed avoid resistance synergistic effect artemisinins choline derivative, which could compete for rate-limiting enzymes in phosphatidylcholine (PC) biosynthetic pathway. AD formulated into liposomes (ADLs) thin-film hydration method. Efficacy ADLs...
ABSTRACT Racial differences in antiretroviral treatment responses remain incompletely explained and may be a consequence of differential pharmacokinetics (PK) associated with race. Raltegravir, an inhibitor HIV-1 integrase, is commonly used the HIV-infected patients, many whom are African-American. However, there few data regarding PK raltegravir African-Americans. men women, self-described as African-American naive to therapy were treated (RAL) at 400 mg twice day, plus fixed dose...
Objective: The possible enhancing effect of anlotinib on programmed death receptor ligand (PD-L1) antibody and the efficacy-predicting power PD-L1 in micro-conduit endothelium, including lymphatic endothelial cells (LECs) blood (BECs), were determined to identify patients who would benefit from this treatment. Methods: positivity LECs, BECs, tumor (TCs) was assessed using paraffin sections with multicolor immunofluorescence an investigator’s brochure clinical trial TQB2450 (PD-L1 antibody)...
Docetaxel (DTX) solution has some serious adverse side effects. A redox-responsive DTX prodrug synthesized in our laboratory was used to prepare self-assembled nanoparticles (DSNPs) with the method of nanoprecipitation. This study aimed at optimizing formulation develop stable preparation for delivery DTX. Single-factor test evaluate effects concentration prodrug, stirring speed, types stabilizers and temperature on prescription process DSNPs. The particle size polydispersity index were...
To develop new, more effective and lower toxicity antitumor dihydroartemisinin (DHA) nanocomplexes, a DHA prodrug synthesized in this study was used to prepare self-assembled nanocomplexes (DHANPs) by molecular self-assembly technology. The optimization, pharmacokinetics vitro vivo efficiency of DHANPs were assessed. results showed that the entrapment efficiency, drug loading, particle size zeta potential optimized formulation 92.37 ± 3.68%, 76.98 3.07%, 145.9 2.11 nm -16.0 0.52 mV,...
The compound 20(S),25-epoxydammarane-3β,12β,24α-triol (24-hydroxy-panaxadiol or 24-OH-PD), isolated from the red Panax ginseng CA Meyer possesses anticancer activity. Our aim was to study pharmacokinetic characteristics of 24-OH-PD, which is essential for pre-clinical research during development new drugs. In this study, a simple and sensitive ultra-performance liquid chromatography-mass spectrometry (LC-MS/MS) method established used studying pharmacokinetics, in vitro protein binding,...
This study describes first dose and steady state pharmacokinetics of raltegravir (RAL) in cervicovaginal fluid (CVF) blood plasma (BP).Three cohorts women were enrolled sequentially a single-site, open-label pharmacokinetic oral 400 mg twice daily: HIV-negative premenopausal, HIV-infected premenopausal post-menopausal women. BP CVF collected over 12 h after single observed at state. RAL concentrations measured by HPLC-MS methods. Data are expressed as median (IQR). The ANOVA rank-sum test...
Background HIV may amplify immunological, physiological and functional changes of ageing. We determined associations frailty phenotype, a T-cell senescence marker (p16 INK4a expression), age demographics with exposures the intracellular metabolites (IM) endogenous nucleotides (EN) tenofovir/emtricitabine (TFV/FTC), efavirenz (EFV), atazanavir (ATV) ritonavir (RTV). Methods Plasma peripheral blood mononuclear cell samples for drug, IM EN concentrations were collected at four time points in...