A5079428721- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Immune cells in cancer
- Galaxies: Formation, Evolution, Phenomena
- Dental Radiography and Imaging
- Astronomy and Astrophysical Research
- Medical Image Segmentation Techniques
- Stellar, planetary, and galactic studies
- Glioma Diagnosis and Treatment
- Total Knee Arthroplasty Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone health and osteoporosis research
- Ultrasound and Hyperthermia Applications
- Pancreatic and Hepatic Oncology Research
- Advanced Radiotherapy Techniques
- Angiogenesis and VEGF in Cancer
- Knee injuries and reconstruction techniques
- Cell Adhesion Molecules Research
- Appendicitis Diagnosis and Management
- Atomic and Subatomic Physics Research
- Radiation Therapy and Dosimetry
- Systemic Sclerosis and Related Diseases
Oxford University Hospitals NHS Trust
2025
Oncology Specialists
2024
University of Oxford
2014-2023
CRUK/MRC Oxford Institute for Radiation Oncology
2013-2023
Cancer Research UK
2015-2022
Medical Research Council
2011-2019
Brigham Young University
2019
Science Oxford
2013
University of Cambridge
2013
Imperial College London
2013
Because metastasis is associated with the majority of cancer-related deaths, its prevention a clinical aspiration. Prostanoids are large family bioactive lipids derived from activity cyclooxygenase-1 (COX-1) and COX-2. Aspirin impairs biosynthesis all prostanoids through irreversible inhibition both COX isoforms. Long-term administration aspirin leads to reduced distant metastases in murine models trials, but isoform, downstream prostanoid, cell compartment responsible for this effect yet be...
Using 10 095 galaxies (B < 20 mag) from the Millennium Galaxy Catalogue, we derive B-band luminosity distributions and selected bivariate brightness for galaxy population subdivided by eyeball morphology; Sérsic index (n); two-degree Field Redshift Survey (2dFGRS) η parameter; rest-(u−r) colour (global core); MGC continuum shape; half-light radius; (extrapolated) central surface brightness; inferred stellar mass-to-light ratio. All subdivisions extract highly correlated subsets of which...
Liver metastasis from colorectal cancer is a leading cause of mortality. Myeloid cells play pivotal roles in the metastatic process, but their prometastatic functions liver remain incompletely understood. To investigate role, we simulated C57BL/6 mice through intrasplenic inoculation MC38 colon carcinoma cells. Among heterogeneous myeloid infiltrate, identified distinct population CD11b/Gr1mid different other populations previously associated with metastasis. These increased number...
We present a spectroscopic survey of almost 15 000 candidate intermediate-redshift luminous red galaxies (LRGs) brighter than i= 19.8, observed with 2dF on the Anglo-Australian Telescope. The targets were selected photometrically from Sloan Digital Sky Survey (SDSS) and lie along two narrow equatorial strips covering 180 deg2. Reliable redshifts obtained for 92 per cent selection is very efficient: over 90 have 0.45 < z 0.8. More 80 ∼11 pure absorption-line spectra consistent passively...
Brain metastasis is a common complication of cancer patients and associated with poor survival. Histological data from brain metastases suggest that microglia are the major immune population activated around metastatic foci. Microglia macrophages have ability to polarize different phenotypes exert both tumorigenic cytotoxic effects. However, role microglia/macrophages during early stages growth in has not yet been determined. The aim this study was profile microglial/macrophage activation...
Poly(ADP-ribose) polymerase (PARP) inhibitors are increasingly being studied as cancer drugs, single agents, or a part of combination therapies. Imaging PARP using radiolabeled inhibitor has been proposed for patient selection, outcome prediction, dose optimization, genotoxic therapy evaluation, and target engagement imaging novel PARP-targeting agents. <b>Methods:</b> Here, via the copper-mediated <sup>18</sup>F-radiofluorination aryl boronic esters, we accessed, first time (to our...
We recover the joint and individual space density surface-brightness distribution(s) of galaxies from Millennium Galaxy Catalogue (MGC). The MGC is a local survey spanning 30.9 deg2 probing approximately 1–2 mag arcsec−2 deeper than either Two-Degree Field Redshift Survey (2dFGRS) or Sloan Digital Sky (SDSS). contains 10095 to BMGC < 20 with 96 per cent spectroscopic completeness. For each galaxy we derive K-corrections seeing-corrected sizes. implement luminosity–surface-brightness...
Abstract Aim: To determine the cross‐sectional association of osteoporotic status patients with number their teeth, and without taking into account age and/or smoking. Material & Methods: At four centres, study recruited 665 females aged 45–70 years teeth was counted for 651 subjects. Bone density measured at total hip, femoral neck lumbar spine. Results: The mean in subjects 3.3 fewer than normal 2.1 if those no were excluded. between osteoporosis having <6 or <28 remained...
Excessive acetabular cover secondary to a retroverted acetabulum causes pincer impingement, which may cause early osteoarthritis of the hip. Our aim was determine if there relationship between version and Using image processing analysis software we studied 117 CT images hip in patients aged less than 65 years who had undergone virtual colonoscopy. The mean joint space 18 hips with retroversion narrower compared 99 normal alignment (p < 0.0001). A correlation r = 0.46 0.01) found right 0.31...
Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and a leading cause of cancer-related death. Pre-clinical research CRC predominately utilizes cell lines grown in tissue culture. Here, we demonstrate that metastases organoids derived from human specimens recapitulate some aspects disease. Human pathological were obtained following consent. Tumor disaggregates plated allowed to expand. markers identified by immunofluorescence. Stem genes analysed QPCR flow...
ABSTRACT Tenofovir gel (1%) is being developed as a microbicide for the prevention of human immunodeficiency virus (HIV) infection and has been shown to reduce transmission women by 39%. The also prevents in macaques when applied intravaginally or intrarectally prior challenge with simian-human (SHIV), but very little pharmacokinetic information available help extrapolate data humans thus inform future development activities. We have determined pharmacokinetics tenofovir following...
Significance Acidic pH may distinguish aggressive from more indolent cancers. The limitation on testing this hypothesis to date has been the difficulty of measuring acidic in Here we show that retention low insertion peptide (pHLIP) Variant 3 (Var3) reflects pH. Using pHLIP Var3, its ability detect cancer with a false-positive rate genetically engineered model murine breast cancer, paving way for probe clinical situations.
Abstract Purpose: To describe a combination of techniques using the excellent volumetric capacities magnetic resonance imaging (MRI) while avoiding anesthesia and maintaining high‐throughput capability for tumor volume measurement in awake mouse. This approach presents an alternative to calipers which, although cheap, fast, easy use, introduce many biases estimation. Materials Methods: The murine CaNT subcutaneous xenograft model was used. A quiet modestly T2‐weighted spin‐echo scan acquired...
Angiogenesis is an essential component of tumour growth and, consequently, important target both therapeutically and diagnostically. The cell adhesion molecule α(v)β(3) integrin a specific marker angiogenic vessels the most prevalent vascular that binds amino acid sequence arginine-glycine-aspartic (RGD). Previous studies using RGD-targeted nanoparticles (20-50 nm diameter) iron oxide (NPIO) for magnetic resonance imaging (MRI) angiogenesis, have identified number limitations, including...
Myeloid cells are known to mediate metastatic progression. Here, we attempted elucidate the mechanisms underlying these effects by identifying gene expression alterations in cancer forming hepatic metastases after myeloid cell depletion. Hepatic heavily infiltrated CD11b + cells. We established transgenic CD11b‐diphtheria toxin receptor mice intrasplenic injection of MC38 colon and Lewis lung carcinoma before depleting with diphtheria toxin. depletion inhibited growth a marked diminishment...
Nanomedicines allow active targeting of cancer for diagnostic and therapeutic applications through incorporation multiple functional components. Frequently, however, clinical translation is hindered by poor intratumoural delivery distribution. The application physical stimuli to promote tumour uptake a viable route overcome this limitation. In study, ultrasound-mediated cavitation microbubbles was investigated as mean enhancing the liposome designed chemo-radionuclide therapy targeted EGFR...
Molecular radiotherapy using <sup>177</sup>Lu-DOTATATE is a most effective treatment for somatostatin receptor–expressing neuroendocrine tumors. Despite its frequent and successful use in the clinic, little or no radiobiologic considerations are made at time of planning delivery. On positive uptake on octreotide-based PET/SPECT imaging, usually administered as standard dose number cycles without adjustment peptide uptake, dosimetry, DNA damage effects tumor. Here, we visualized quantified...
Two-factor authentication (2FA) defends against password compromise by a remote attacker. We surveyed 4,275 students, faculty, and staff at Brigham Young University to measure user sentiment about Duo 2FA one year after the university adopted it. The results were mixed. A majority of participants felt more secure using it was easy use. About half all reported least instance being locked out their account because an inability authenticate with Duo. found that students faculty generally had...