A5032938289- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Electromagnetic Fields and Biological Effects
- Neuroblastoma Research and Treatments
- Chemical Reactions and Isotopes
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Reproductive Biology and Fertility
- Prostate Cancer Treatment and Research
- Radiation Detection and Scintillator Technologies
- Radiomics and Machine Learning in Medical Imaging
- Sperm and Testicular Function
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Brain Metastases and Treatment
- Radioactive Decay and Measurement Techniques
- Nanoparticle-Based Drug Delivery
- Effects of Radiation Exposure
- Hepatocellular Carcinoma Treatment and Prognosis
- Muon and positron interactions and applications
- Ion-surface interactions and analysis
- Radiation Dose and Imaging
- Mass Spectrometry Techniques and Applications
Theranostics (New Zealand)
2024
University of Oxford
2013-2022
CRUK/MRC Oxford Institute for Radiation Oncology
2011-2022
Australian and New Zealand Intensive Care Society
2020-2021
GANIL
2019-2020
Tshwane University of Technology
2006-2017
Medical Research Council
2011-2015
Cancer Research UK
2015
Royal Marsden Hospital
2015
Churchill Hospital
2011
Several recent studies have indicated that radiofrequency electromagnetic fields (RF-EMF) an adverse effect on human sperm quality, which could translate into fertilization potential. This study evaluated the of RF-EMF sperm-specific characteristics to assess fertilizing competence sperm. Highly motile spermatozoa were exposed for 1 h 900-MHz mobile phone radiation at a specific absorption rate 2.0 W/kg and examined various times after exposure. The acrosome reaction was using flow...
Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often limited by a low payload resulting in inadequate delivery of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We developed facile synthetic method radiolabeling indium-111 (111In) epidermal growth factor (EGF)-gold nanoparticles (111In-EGF-Au NP) with high payload.Materials methods EGF-Au NP were prepared via an interaction between gold the disulphide bonds EGF...
Several radionuclides used in medical imaging emit Auger electrons, which, depending on the targeting strategy, either may be exploited for therapeutic purposes or contribute to an unintentional mean absorbed dose burden. In this study, virtues of 12 electron–emitting were evaluated terms cellular <i>S</i> values concentric and eccentric cell–nucleus arrangements by comparing their dose-point kernels. <b>Methods:</b> The Monte Carlo code PENELOPE was transport full particulate spectrum...
Radiopharmaceutical dosimetry depends on the localization in space and time of radioactive sources requires estimation amount energy emitted by deposited within targets. In particular, when computing resources are not accessible, this task can be performed using precomputed tables specific absorbed fractions (SAFs) or S values based dosimetric models. The aim OpenDose collaboration is to generate make freely available a range data tools. <b>Methods:</b> brings together expertise from 18...
Abstract Recent reports suggest that mobile phone radiation may diminish male fertility. However, the effects of this on human spermatozoa are largely unknown. The present study examined induction apoptosis-related properties in spermatozoa. Ejaculated, density-purified, highly motile were exposed to at specific absorption rates (SARs) 2.0 and 5.7 W/kg. At various times after exposure, flow cytometry was used examine caspase 3 activity, externalization phosphatidylserine (PS), DNA strand...
Objective Iodine-131-labelled meta-iodobenzylguanidine (131I-mIBG) therapy is an established treatment modality for relapsed/refractory neuroblastoma, most frequently administered according to fixed or weight-based criteria. We evaluate response and toxicity following a dosimetry-based, individualized approach. Materials methods A review of 44 treatments in 25 patients treated with 131I-mIBG was performed. Patients received relapse (n=9), refractory disease (n=12), surgically unresectable...
Molecular radiotherapy using <sup>177</sup>Lu-DOTATATE is a most effective treatment for somatostatin receptor–expressing neuroendocrine tumors. Despite its frequent and successful use in the clinic, little or no radiobiologic considerations are made at time of planning delivery. On positive uptake on octreotide-based PET/SPECT imaging, usually administered as standard dose number cycles without adjustment peptide uptake, dosimetry, DNA damage effects tumor. Here, we visualized quantified...
Abstract Background Brain metastases (BM) develop frequently in patients with breast cancer. Despite the use of external beam radiotherapy (EBRT), average overall survival is short (6 months from diagnosis). The therapeutic challenge to deliver molecularly targeted therapy at an early stage when relatively few metastatic tumor cells have invaded brain. Vascular cell adhesion molecule 1 (VCAM-1), overexpressed by nearby endothelial during stages BM development, a promising target. aim this...
Abstract Ejaculated, density purified, human spermatozoa were exposed to pulsed 900 MHz GSM mobile phone radiation at two specific absorption rate levels (SAR 2.0 and 5.7 W/kg) compared with controls over time. Change in sperm mitochondrial membrane potential was analysed using flow cytometry. Sperm motility determined by computer assisted analysis (CASA). There no effect of on potential. This also the case for all kinematic parameters assessed a SAR W/kg. However, time, straight line...
Background Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon uptake [64Cu]-CuATSM, [99mTc]-HL91 [18F]-FMISO in a preclinical model tumor hypoxia. Methodology/Principal Findings The effect was studied 6 groups CaNT-bearing CBA mice using or [18F]-FMISO. Mice were anaesthetised with isoflurane air, pure...
Brain metastases develop frequently in patients with breast cancer, and present a pressing therapeutic challenge. Expression of vascular cell adhesion molecule 1 (VCAM-1) is upregulated on brain endothelial cells during the early stages metastasis provides target for detection treatment metastases. The aim this study was to use model evaluate efficacy α-emitting radionuclides,
The spatial distribution of radiopharmaceuticals that emit short-range high linear-energy-transfer electrons greatly affects absorbed dose and biological effectiveness. purpose this study was to investigate the effect heterogeneous radionuclide on tumor control probability (TCP) in a micrometastasis model. <b>Methods:</b> cancer cell lines MDA-MB-468, SQ20B, 231-H2N were grown as spheroids represent micrometastases. intracellular representative radiopeptide (<sup>111</sup>In-labeled...
The aim of this study was to investigate the impact decay data provided by newly developed stochastic atomic relaxation model BrIccEmis on dose point kernels (DPKs - radial distribution around a unit source) and S-values (absorbed per cumulated activity) 14 Auger electron (AE) emitting radionuclides, namely
Evaluation of the acrosome reaction can shed light on fertilising competence spermatozoa. To eliminate false-positive results when evaluating status human sperm cells, two viability probes propidium iodide (PI) and 7-amino-actinomycin D (7-AAD) were compared for their ability to stain nonviable cells post-fixation permeabilisation. Both mean fluorescence % dead differed significantly with time (P < 0.0001). Unlike PI, 7-AAD did not leach from remained stable up 4 h. Furthermore, proved be a...
Objective: Neuroblastoma has one of the lowest survival rates all childhood cancers, despite use intensive treatment regimens. Preclinical models neuroblastoma are essential for testing new multimodality protocols, including those that involve radiotherapy (RT). The aim this study was to develop a robust method RT planning and tumour response monitoring based on combined MRI cone-beam CT (CBCT) imaging apply it widely studied mouse xenograft model neuroblastoma, SK-N-SH. Methods: As part...
Water-pipe smoking is growing in popularity, especially among young people, because of the social nature session and assumption that effects are less harmful than those cigarette smoking. It has however been shown a single water-pipe produces 24-hour urinary cotinine level equivalent to 10 cigarettes per day. Aim. We aimed measure carboxyhaemoglogin (COHb) blood levels before after sessions. Method. Self-confessed smokers older 18 years (N=30) volunteered smoke or have their COHb measured...