A5088571442- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Radiation Dose and Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Peptidase Inhibition and Analysis
- Thyroid Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Pediatric Urology and Nephrology Studies
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Radiation Effects and Dosimetry
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Nuclear reactor physics and engineering
- Hydrogen embrittlement and corrosion behaviors in metals
- Digital Radiography and Breast Imaging
- Lymphoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
University of Wollongong
2014-2025
Nepean Hospital
2023-2025
Illawarra Health and Medical Research Institute
2020-2023
Western NSW Local Health District
2023
St Vincent's Hospital Sydney
2020-2022
St Vincent's Hospital
2022
University Ucinf
2019
University Hospital Southampton NHS Foundation Trust
2013
The University of Sydney
2013
CRUK Lung Cancer Centre of Excellence
2009
Radiopharmaceutical dosimetry depends on the localization in space and time of radioactive sources requires estimation amount energy emitted by deposited within targets. In particular, when computing resources are not accessible, this task can be performed using precomputed tables specific absorbed fractions (SAFs) or S values based dosimetric models. The aim OpenDose collaboration is to generate make freely available a range data tools. <b>Methods:</b> brings together expertise from 18...
In preclinical models, radioimmunotherapy with (131)I-A5B7 anti-carcinoembryonic antigen (CEA) antibody ((131)I-A5B7) combined the vascular disruptive agent combretastatin-A4-phosphate (CA4P) produced cures unlike either alone. We conducted a phase I trial determining dose-limiting toxicity (DLT), maximum tolerated dose, efficacy, and mechanism of this combination in patients gastrointestinal adenocarcinomas.Patients had CEA 10 to 1,000 microg/L, QTc < or =450 ms, no cardiac...
Geant4, a Monte Carlo Simulation Toolkit extensively used in bio-medical physics, is continuous evolution to include newest research findings improve its accuracy and respond the evolving needs of very diverse user community. In 2014, G4-Med benchmarking system was born from effort Geant4 Medical Benchmarking Group, benchmark monitor for medical physics applications. The first described our Physics Special Report published 2021. Results tests were reported 10.5. this work, we describe...
Breast cancers are most frequently oestrogen receptor (ER) and progesterone (PR) positive [18F]Fluorodeoxyglucose PET-CT (FDG) has lower sensitivity for these subtypes. The gastrin-releasing peptide (GRPR) is overexpressed in ER+/PR+ breast cancers. This study assessed the safety potential of [64Cu]Cu-Sarcophagine (SAR)-Bombesin PET/CT (BBN) re-staging metastatic ER+/PR+/human epidermal growth-factor-2-negative (HER2-) cancer. Seven patients with ER+/PR+/HER2- cancer undergoing staging...
Abstract Purpose: There is a need for new treatments Hodgkin and T-cell lymphoma due to the development of drug resistance in proportion patients. This phase I study radioimmunotherapy used CHT-25, chimeric antibody α-chain interleukin-2 receptor, CD25, conjugated iodine-131 (131I) patients with refractory CD25-positive lymphomas. Experimental Design: Fifteen were treated (Hodgkin lymphoma, 12; angioimmunoblastic 1; adult leukemia/lymphoma, 2). Tumor was monitored by computed tomography all...
Four methodologies were evaluated for quantifying kilovoltage cone-beam computed tomography (CBCT) dose: the Cone-Beam Dose Index (CBDI), IAEA Report 5 recommended methodology (IAEA), AAPM Task Group 111 (TG111), and current dose metric; Computed Tomography (CTDI) on two commercial Varian CT imaging systems; Clinac iX On-Board Imager (OBI); TrueBeam X-ray Imaging system (XI). The TG111 measured highest overall (21.199 ± 0.035 mGy OBI 22.420 0.002 XI pelvis imaging) due to full scatter of...
There is evidence that nonuniform activity distributions within tumors might cause targeted radionuclide therapy (TRT) to fail. The aim of this study was investigate the effects temporal and spatial behavior radioactivity in TRT, focusing on heterogeneous radiopharmaceutical at a multicellular scale. Various level from three radionuclides (32P, 90Y, 131I) were simulated cubic matrices (1- 3-mm side). in-house software package DOVE used calculate dose-rate maps, survival fractions calculated...
Abstract The reference adult male and female voxel phantoms described in the International Commission on Radiological Protection (ICRP) publication 110 have been successfully implemented a Geant4 application named ICRP110Phantoms . allows users to simulate either whole or partial phantom, including as little single cross-sectional slice. estimate absorbed dose individual voxels entire organs. As example of application, was used deposited by mono-energetic 125 MeV proton pencil beam, incident...
HDR BrachyView is a novel in-body dosimetric imaging system for real-time monitoring and verification of the source position in high dose rate (HDR) prostate brachytherapy treatment. It based on high-resolution pixelated detector array with semi-cylindrical multi-pinhole tungsten collimator designed to fit inside compact rectal probe, able resolve 3D maximum error 1.5 mm. This paper presents an evaluation additional that will be delivered patient as result backscatter radiation from...
Assessment of volume distribution (VD) and half-life (T1/2) values during glomerular filtration rate (GFR) investigations is a useful quality control check. The aim this study was to derive reference data for VD T1/2 also provide GFR from studies performed using Tc-diethylenetriaminepentaacetic acid (Tc-DTPA).This retrospective 126 healthy potential kidney donors (age range 18-59 years). evaluated Tc-DTPA plasma clearance the 2004 British Nuclear Medicine Society guidelines. association...
We aimed to investigate the validity of partition model (PM) in estimating absorbed doses liver tumour (), normal tissue () and lungs when cross-fire irradiations between these compartments are being considered. MIRD-5 phantom incorporated with various treatment parameters, i.e. involvement (TI), tumour-to-normal uptake ratio (T/N) lung shunting (LS), were simulated using Geant4 Monte Carlo (MC) toolkit. 108 track histories generated for each combination three parameters obtain dose per...
A software package to investigate absorbed doses and dose-rates at the cellular multicellular scale has been developed that considers two- three-dimensional activity distributions makes use of analytical representations point-dose kernels for 131I, 32P, 90Y. This allows cell assemblies be simulated by definition number, size, geometry cells their nuclei, radionuclide uptake can specified occur within nucleus, cytoplasm, membrane, or extracellular space. The validated a comparison with...
90Y-radioembolization is a palliative treatment for liver cancer. 90Y decays via beta emission, making imaging difficult due to absence of gamma radiation. Since post-procedure crucial, several theranostic radionuclides have been explored as alternatives. However, exposures radiation throughout the caused concern organs near liver. Geant4 Monte Carlo simulation using MIRD Pamphlet 5 reference phantom was carried out. A spherical tumour with 4.3cm radius modelled within 1.82GBq sources were...
The distribution of therapeutic radiopharmaceuticals in volumes smaller than those that can be fully resolved by the imaging system, such as PET and SPECT scanners, is usually assumed to homogeneous. aim this study was investigate implications an assumption at a scale defined multicellular for heterogeneous activity localizations 32P, 90Y, 131I. Dose-rate distributions from radioactivity uptakes have been calculated cubic 1, 3, 4 mm using in-house software package DOVE. These studied use...
Abstract Background Radioiodine ( 131 I) therapy in treatment of thyroid cancer, has a biological clearance that is significantly reduced end-stage kidney disease (ESKD), leading to increased radiation exposure and potential myelotoxicity. For ESKD patients on haemodialysis (HD), there no standardized approach I administration scheduling HD following. Methods Two with were treated for cancer. Local protocol was modified account HD. Modifications made existing infrastructure additional...
The aim of this work was to estimate tumor-absorbed doses delivered from the administration fixed activities 186Re-HEDP for treatment bone metastases prostate cancer. variations and reproducibility in estimated absorbed dose owing reconstruction algorithm used (OSEM vs. FBP) were also analysed. For aim, correction methods scatter attenuation kept identical, whereas same calibration data thresholding techniques obtain quantification. This study carried out spinal pelvic lesions 7 patients....
Abstract This study aimed to evaluate the absorbed doses received by organs at risk (OARs) following prostate treatment with permanent Iodine-125 ( 125 I) brachytherapy seeds. In order simulate an enlarged abnormal due malignancy, MIRD5 adult male anthropomorphic phantom (readily available in Geant4 Monte Carlo package) was modified increasing volume 35 cm 3 . The seeds were constructed outer cylindrical dimension of 4.5 mm (length) × 0.8 (diameter). effects various activity per seed (0.5,...
Dosimetry software tools developed for Radiopharmaceutical Therapy, such as OLINDA/EXM or IDAC-Dose, account only radiation dose to organs from radiopharmaceutical taken up in other organs.The aim of this study is present a methodology, that can be applied any voxelised computational model, able cross-dose tumors shape and number enclosed within an organ.A Geant4 application using hybrid analytical/voxelised geometries has been extension the ICRP110_HumanPhantom advanced example validated...
Abstract Background and Aims Radioactive iodine (RAI) 131I is used in the adjuvant treatment of thyroid carcinoma following thyroidectomy. renally excreted, with reduced clearance patients end-stage kidney disease (ESKD). There are no established protocols for RAI dosing, timing dialysis safety this population [1]. We describe a single-centre experience modified protocol setup haemodialysis (HD) including serum measurements to monitor red marrow toxicity. present outcomes two HD patients....
Three alternative methodologies to the Computed-Tomography Dose Index for evaluation of Cone-Beam Computed Tomography dose are compared, Index, IAEA Human Health Report No. 5 recommended methodology and AAPM Task Group 111 methodology. The protocols were evaluated Pelvis Thorax scan modes on Varian® On-Board Imager Truebeam kV XI imaging systems. weighted planar average was highest across all scans, with CBDI being second overall. A 17.96% 1.14% decrease from TG-111 protocol mode 18.15%...
Fast, reliable and accurate PET image segmentation is essential in the delineation of volumes when images are used for radiation therapy treatment planning. The aim this study was to investigate performance on static gated a 3D random walk algorithm, which makes use an automated seed selection method adaptive probability threshold (3DAARW). This algorithm compared published 2D (2DAARW) algorithms (2DARW 3DARW) fixed same methodology as 3DAARW. Optimal parameters all 4 methods were determined...