Elgene Lim
A5088828593- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- PARP inhibition in cancer therapy
- Cancer-related gene regulation
- Genetics and Neurodevelopmental Disorders
- Hippo pathway signaling and YAP/TAZ
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Prostate Cancer Treatment and Research
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- DNA Repair Mechanisms
- Fibroblast Growth Factor Research
- Metastasis and carcinoma case studies
- BRCA gene mutations in cancer
St Vincent's Clinic
2016-2025
Garvan Institute of Medical Research
2016-2025
UNSW Sydney
2016-2025
The Kinghorn Cancer Centre
2016-2025
St Vincent's Hospital
2016-2025
St. Vincent's Hospital
2025
Saint Vincent's Catholic Medical Center
2025
St Vincents Institute of Medical Research
2024
Ludwig-Maximilians-Universität München
2024
Memorial Sloan Kettering Cancer Center
2024
Abstract Motivation: A gene set test is a differential expression analysis in which P-value assigned to of genes as unit. Gene tests are valuable for increasing statistical power, organizing and interpreting results relating patterns across different experiments. Existing methods based on permutation. Methods that rely permutation probes unrealistically assume independence genes, while those sample suitable only two-group comparisons with good number replicates each group. Results: We...
Abstract Introduction Molecular characterization of the normal epithelial cell types that reside in mammary gland is an important step toward understanding pathways regulate self-renewal, lineage commitment, and differentiation along hierarchy. Here we determined gene expression signatures four distinct subpopulations isolated from mouse gland. The were used to interrogate models tumorigenesis compare with their human counterpart subsets identify conserved genes networks. Methods RNA was...
Abstract The cellular and molecular basis of stromal cell recruitment, activation crosstalk in carcinomas is poorly understood, limiting the development targeted anti-stromal therapies. In mouse models triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibroblasts (CAFs) to provide a supportive niche for acquisition chemo-resistant, stem (CSC) phenotype via FGF5 expression production fibrillar collagen. Stromal treatment...
Adjuvant abemaciclib combined with endocrine therapy (ET) previously demonstrated clinically meaningful improvement in invasive disease-free survival (IDFS) and distant relapse-free (DRFS) hormone receptor-positive, human epidermal growth factor receptor 2-negative, node-positive, high-risk early breast cancer at the second interim analysis, however follow-up was limited. Here, we present results of prespecified primary outcome analysis an additional analysis.This global, phase III,...
Although poly(ADP-ribose) polymerase (PARP) inhibitors are active in homologous recombination (HR)-deficient cancers, their utility is limited by acquired resistance after restoration of HR. Here, we report that dinaciclib, an inhibitor cyclin-dependent kinases (CDKs) 1, 2, 5, and 9, additionally has potent activity against CDK12, a transcriptional regulator In BRCA-mutated triple-negative breast cancer (TNBC) cells patient-derived xenografts (PDXs), dinaciclib ablates restored HR reverses...
The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays crucial role shaping their progression. Many desmoplastic including breast cancer involve significant accumulation type I collagen. However, recently it has become clear precise distribution organisation molecules such as collagen equally important abundance. Cancer-associated fibroblasts (CAFs) coexist within tissues play both pro- anti-tumourigenic roles through remodelling...
The androgen receptor is a tumour suppressor in oestrogen receptor-positive breast cancer. activity and safety of enobosarm, an oral selective modulator, was evaluated women with (ER)-positive, HER2-negative, (AR)-positive disease.
PURPOSE To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor–positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455 ). METHODS Post-/pre-/perimenopausal women, or men, age 18 years older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly...
Overexpression of the prosurvival protein BCL-2 is common in breast cancer. Here we have explored its role as a potential therapeutic target this disease. BCL-2, anti-apoptotic relatives MCL-1 and BCL-XL, proapoptotic BH3-only ligand BIM were found to be coexpressed at relatively high levels substantial proportion heterogeneous tumors, including clinically aggressive basal-like cancers. To determine whether BH3 mimetic ABT-737 that neutralizes BCL-W had efficacy targeting BCL-2–expressing...
Metastatic tumour recurrence due to failed treatments remains a major challenge of breast cancer clinical management. Here we report that interleukin-1 receptor-associated kinase 1 (IRAK1) is overexpressed in subset cancers, particular triple-negative (TNBC), where it acts drive aggressive growth, metastasis and acquired resistance paclitaxel treatment. We show IRAK1 overexpression confers TNBC growth advantage through NF-κB-related cytokine secretion metastatic cells exhibit gain...
Abstract BRCA1 promotes homologous recombination–mediated DNA repair (HRR). However, HRR must be tightly regulated to prevent illegitimate recombination. We previously found that function is by the RAP80 complex, but mechanism was unclear. have now observed PARP1 interacts with and poly-ADP-ribosylates (aka PARsylates) BRCA1. PARsylation directed at binding domain downmodulates its function. Moreover, contains a poly-ADP-ribose–interacting binds PARsylated helps maintain stability of...
Understanding how the extracellular matrix impacts function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce laminin (LM) 511 promotes self-renewal and tumor initiation by engaging α6Bβ1 integrin activating Hippo transducer TAZ. Although TAZ important for CSCs, mechanism unknown. observed regulates transcription α5 subunit LM511 formation matrix. These data establish positive feedback loop involving contributes to stemness in cancer.