A5063952839- Bone health and treatments
- Management of metastatic bone disease
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Osteomyelitis and Bone Disorders Research
- Bone Tumor Diagnosis and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Advanced Breast Cancer Therapies
- Bone and Joint Diseases
- Radiopharmaceutical Chemistry and Applications
Republican Oncological Clinical Dispensary
2024
Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
2024
Kazan State Medical Academy
2024
Ministry of Health
2022-2023
PURPOSE To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor–positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455 ). METHODS Post-/pre-/perimenopausal women, or men, age 18 years older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly...
Breast cancer is one of the most significant problems in oncology. This pathology characterized by increased risk fractures associated with postmenopausal decrease bone mineral density, use hormone therapy, and presence osteolytic metastases spine. All these factors can cause non-traumatic spine decreasing patient mobility leading to permanent pain syndrome neurologic deficit. The article presents modern view on osteoporosis problem patients breast metastases. Literature data predictors...
The introduction of chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment hematological diseases, particularly in combating blood cancer. success this cell approach led to development approximately seven commercial CAR-T based drugs. However, application for solid tumors proven be less effective due challenges such as varied antigens tumors, an immunosuppressive tumor environment, limited immune infiltration, reduced activity and toxicity issues. To solve these...
Introduction. Currently, a personalized approach is considered priority in the treatment of malignant neoplasms bones, skin and soft tissues. The decision on plan formed by multidisciplinary team specialists: surgeon, chemotherapist, radiotherapist. active introduction systemic therapy new technologies radiation made it possible to ensure local control disease, which contributed expansion indications for performing organ-preserving surgical interventions. In order improve functional results,...
There have been several recent studies that indicate patients with rheumatological diseases are at a higher risk of developing malignant neoplasms than the general population. This clinical case presents patient ankylosing spondylitis, rare autoimmune disease in women, addition to breast cancer. The close relationship between rheumatology and malignancy highlights challenges terms diagnosis, treatment, prevention, making this highly relevant. Furthermore, also positive effect chemotherapy...
Introduction . In the structure of fractures long tubular bones, pathological account for about 1 %, and 2/3 all cases are associated with bone metastases. Primary tumors complicated by development a fracture in 1– 10 % cases, metastases 8–30 cases. With fracture, as primary manifestation tumor process, rule, patients come to attention orthopedic traumatologists providing emergency care. practice oncologists, there often who have performed deliberately non-radical surgical interventions...
Introduction. Giant cell tumor refers to tumors with an uncertain malignancy potential, has a locally aggressive course. Intra-focal resections performed for giant of long tubular bones are accompanied by the development relapse in 30–46 % cases. The combination pathogenetic therapy surgical intervention makes it possible reduce frequency relapses operable after marginal and intra-focal resections, inoperable provide local control relieve pain. Objective – analyze results combined treatment...