A5001053105- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Hematopoietic Stem Cell Transplantation
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Acute Myeloid Leukemia Research
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
Kyungpook National University Hospital
2009-2024
Kyungpook National University Medical Center
2012-2021
Kyungpook National University
2005-2016
Keimyung University Dongsan Medical Center
2007-2011
Daegu Fatima Hospital
2011
Keimyung University
2007-2011
Ulsan University Hospital
2009
Pusan National University Hospital
2006-2007
Yeungnam University Medical Center
2007
Chonnam National University Hwasun Hospital
2007
PURPOSE To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor–positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455 ). METHODS Post-/pre-/perimenopausal women, or men, age 18 years older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly...
Abstract Purpose: To evaluate a triplet regimen combining immune checkpoint blockade, AKT pathway inhibition, and (nab-) paclitaxel as first-line therapy for locally advanced/metastatic triple-negative breast cancer (mTNBC). Patients Methods: The single-arm CO40151 phase Ib study (NCT03800836), the signal-seeking cohort of IPATunity130 (NCT03337724), randomized III IPATunity170 trial (NCT04177108) enrolled patients with previously untreated mTNBC. Triplet comprised intravenous atezolizumab...
1020 Background: DESTINY-Breast04 (NCT03734029) showed improved progression-free survival (PFS) and overall for T-DXd vs TPC in pts with HER2-low (IHC 1+ or 2+/ISH-negative) mBC. We present exploratory biomarker analysis HER2-low, HR+ Methods: Biopsy specimens collected from 326 after prior treatment were analyzed using RNA-sequencing intrinsic subtypes estimated by PAM50 gene expression. ESR1 PIK3CA mutations known alterations associated resistance to CDK4/6 inhibitors (CDK4/6i) assessed...
Abstract BACKGROUND Standard allogeneic bone marrow transplantation (BMT) offers only a small chance of cure for most adult patients with advanced hematologic malignancies. The authors postulated that peripheral blood stem cell (PBSCT) followed by prophylactic growth factor‐primed donor lymphocyte infusion (DLI) cells reserved at harvest would maximize the graft‐versus‐tumor effects in malignancies who had high risk recurrence. METHODS Seventeen recurrence were allocated on an...
We aimed to evaluate the efficacy and safety of concurrent chemoradiotherapy with capecitabine cisplatin in patients locally advanced squamous cell carcinoma head neck (SCCHN). In total, 37 stage III or IV SCCHN were enrolled on study. The chemotherapy consisted two cycles intravenous 80 mg m−2 day 1 oral 825 twice daily from 14 at 3-week intervals. radiotherapy (1.8–2.0 Gy fraction day−1 a total dose 70–70.2 Gy) was delivered primary tumour site neck. sites as follows: cavity (n=6),...
The present study was conducted to evaluate the efficacy and safety of a combination regimen capecitabine plus irinotecan in patients with advanced gastric cancer. Patients previously untreated metastatic or recurrent, measurable cancer received oral 1000 mg m(-2) twice daily from day 1 14 intravenous 100 on days 8, based 3-week cycle. Forty-one were enrolled current study, among whom 38 assessable for 40 toxicity. Three complete responses 16 partial confirmed, giving an overall response...
The present study was conducted to evaluate the efficacy and safety of a combination regimen docetaxel plus oxaliplatin in patients with advanced gastric cancer. Patients previously untreated metastatic or recurrent, measurable cancer received intravenous 65 mg m−2 120 on day 1 based 3-week cycle. Forty-two were enrolled current study, among whom 39 assessable for all toxicity. One complete response 18 partial responses confirmed, giving an overall rate 45.2% (95% confidence interval (CI);...
Background. The occurrence of autoantibodies has been reported in allogeneic stem-cell recipients, but the association this with chronic graft-versus-host disease (cGVHD) or survival remains uncertain. Methods. A total 121 consecutive patients who underwent transplantation from November 2001 to March 2008 and survived at least 3 months after were included study. Results. Forty-seven (38.8%) expressed one various transplantation. Antinuclear antibody was positive 22 (18.2%), antidouble...
Recently, several breast surgeons have reported a new method for sentinel lymph node biopsy (SLNB) by using indocyanine green (ICG) with infrared camera. This study aimed to determine whether the nodes (LNs) ICG uptake are true SLNs and assess reliability of only SLNB. Data were prospectively collected between April September 2021. All palpable LNs fat-trimmed ordered from high low signal gamma detector. The degree radioisotope brightness staining axillary detected fluorescent camera...
The present study analyzed the functional insertion/deletion polymorphism in promoter region of NFKB1 gene and their impact on prognosis for patients with gastric adenocarcinoma.Four hundred seventy two consecutive curatively resected adenocarcinoma were enrolled study. genomic DNA was extracted from paraffin-embedded tissue -94 ATTG determined using a polymerase chain reaction-restriction fragment length assay.The successfully amplified 97.8% cases. There no sexual differences relation to...