A5077797186- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Pelvic floor disorders treatments
- Estrogen and related hormone effects
- Gynecological conditions and treatments
- Endometrial and Cervical Cancer Treatments
- Sperm and Testicular Function
- Assisted Reproductive Technology and Twin Pregnancy
- Anorectal Disease Treatments and Outcomes
- Urological Disorders and Treatments
- Pelvic and Acetabular Injuries
- Ureteral procedures and complications
- Ovarian cancer diagnosis and treatment
- Growth Hormone and Insulin-like Growth Factors
- Pregnancy-related medical research
- Ectopic Pregnancy Diagnosis and Management
- Sexual Differentiation and Disorders
- Minimally Invasive Surgical Techniques
- Effects and risks of endocrine disrupting chemicals
- Reproductive Health and Technologies
- Omental and Epiploic Conditions
- Maternal and fetal healthcare
University of Ulsan
2015-2024
Asan Medical Center
2014-2024
Ulsan College
2014-2024
Yonsei University
2024
Inha University
2014
PURPOSE To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor–positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455 ). METHODS Post-/pre-/perimenopausal women, or men, age 18 years older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly...
We performed the present prospective case-control study to evaluate whether plasma concentrations of phthalate esters are elevated in women with advanced-stage endometriosis a Korean population. Measuring levels monoethylhexyl and di-(2-ethylhexyl) 97 169 control by liquid chromatography–tandem mass spectrometry, we found that phthalate, as well significantly higher those endometriosis, which supports hypothesis exposure might play role establishment endometriosis. There is growing evidence...
Although phthalates were shown to have several negative effects on reproductive function in animals, its role the pathogenesis of endometriosis remains be elucidated.We aimed investigate vitro and vivo di-(2-ethylhexyl)-phthalate (DEHP) compare urinary levels phthalate metabolites between women with without endometriosis.For experimental studies, we used endometrial cell culture nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse models. We also performed a prospective...
Objective To evaluate the efficacy and safety of dienogest treatment in patients who had received for 12 months or more to treat endometriosis. Methods We analyzed clinical data 188 women with endometriosis been treated 2 mg once a day at single institute. evaluated changes endometriosis-associated pain endometrioma size, recurrence rate, adverse events following administration. Bone mineral density (BMD) was measured were prescribed than 18 months. Results Pain significantly reduced after...
Human microbiota refers to living microorganisms which colonize our body and crucially contribute the metabolism of nutrients various physiologic functions. According recently accumulated evidence, human dysbiosis in genital tract or pelvic cavity could be involved pathogenesis and/or pathophysiology endometriosis. We aimed investigate whether composition microbiome is altered peritoneal fluid women with recruited 45 histological evidence ovarian endometrioma surgical controls without...
The vibration experienced in an ambulance can lead to secondary injury a patient and discourage paramedic from providing emergency care. In this study, with the goal of resolving problem, new isolation bed stage associated magnetorheological (MR) dampers is proposed ensure ride quality as well better care for while he/she being transported. work isolate vibrations vertical, rolling pitching directions reflect reality that occurs ambulance. Firstly, appropriate-sized MR damper designed based...
To evaluate whether the surgical resection or aspiration with ethanol sclerotherapy (AEST) of endometrioma before in vitro fertilization (IVF) affect controlled ovarian stimulation (COS) and IVF outcome infertilie women endometroma undergoing IVF.In this retrospective cohort study, 101 consecutive IVF/intracytoplasmic sperm injection cycles that were performed patients endometrioma(s) between January 2008 December 2012 included. Before IVF, 36 underwent (resection group), 29 had transvaginal...
The gold standard procedure for treating patients with apical pelvic organ prolapse (POP) is sacrocolpopexy. However, no report comparing the two types of single-incision robotic sacrocolpopexy, namely, single-site sacrocolpopexy (SS-RSC) and single-port (SP-RSC) exists. Therefore, we compared safety effectiveness SS-RSC SP-RSC. In this study, 48 who underwent RSC, 40 non-consecutive SS-RSC, 8 consecutive SP-RSC symptomatic POP quantification stage III–IV were eligible 1-year follow-up (FU)...
PROBLEM: To investigate whether antithyroid antibodies (ATAs) affect the pregnancy outcome in euthyroid women undergoing vitro fertilization‐embryo transfer (IVF‐ET). METHOD OF STUDY: Thyroid peroxidase antibody (TPOA) and thyroglobulin (TGA) were measured by radioligand assay kits that used as ATAs 79 patients with tubal or unexplained infertility who enrolled an IVF‐ET program. Women positive for antinuclear antibody, lupus anticoagulant, anticardiolipin rheumatoid factor excluded from our...
Does interleukin-32 (IL-32) play a role in the pathogenesis of endometriosis?IL-32 might be involved endometriosis through increased viability, proliferation and invasion endometrial cells.Endometriosis is characterized as chronic inflammatory disease several proinflammatory cytokines are suggested to its pathophysiology. IL-32, recognized new cytokine strong inducer other cytokines, has been shown serve key modulator diseases.This study included comparison IL-32 levels peritoneal fluids...
To report our experience of fertility preservation (FP) in female cancer patients.We retrospectively analyzed the medical records who underwent elective oocyte or embryo cryopreservation before treatment between January 2015 and December 2020 at Asan Medical Center. We type cancer, rate reuse cryopreserved oocytes embryos, outcomes such as resumption menstruation pregnancy.A total 174 patients 182 retrieval cycles after controlled ovarian stimulation for cryopreservation. The median age was...
Problem We evaluated whether the expression of NF ‐кB p65 subunit is increased in eutopic endometrium and/or ovarian endometrioma women with advanced stage endometriosis, and ascertained vitro effects proinflammatory cytokines on DNA binding endometrial cells. Method Study Immunohistochemistry was performed to compare nuclear immunoreactivity between without endometriosis. The were also analyzed cells treated tumor necrosis factor‐alpha ( TNF ‐α) or interleukin‐1beta IL ‐1β) utilizing...
Endometriosis is defined as the presence of functional endometrial tissue outside uterus, causing diverse progressive symptoms such infertility, pelvic pain, and dysmenorrhea. Although endometriosis has been described since 1800s, mechanisms responsible for its pathogenesis progression remain poorly understood. It well established that grows regresses in an estrogen-dependent fashion disease can be effectively cured by definitive surgery. However, prolonged medical therapy may needed most...
Purpose: Progesterone resistance is thought to be a major factor that contributes progression of endometriosis.However, it not clear what causes progesterone in endometriosis.This study aimed assess whether cytokines or peritoneal fluid can affect receptor (PR) expression endometrial cells and verify PR reduced endometriosis. Materials Methods:The PR-B/A ratio was measured via real-time polymerase chain reaction after vitro culture, which were treated with either tumor necrosis factor-alpha...
Virtual characters are now widely used in games, computer-generated (CG) movies, virtual reality (VR), and communication media. The continued technological innovations motion capture mean that a more natural representation of three-dimensional character’s should be achievable. Many researchers have investigated how interact with their surrounding environment through spatial relationships, which were introduced for adapting preserving character motion. However, technical problems resolved to...
Objective To evaluate the effect of second-line conservative surgery on in vitro fertilization (IVF) outcome comparison with IVF without infertile women ovarian endometrioma recurrence after primary surgery. Methods In this retrospective cohort study, 121 consecutive IVF/intracytoplasmic sperm injection cycles that were performed (n=53) or (control group, n=68) between January 2006 and December 2011 endometrioma(s) for moderate to severe endometriosis included. The two groups compared terms...
Problem The intracellular antioxidant system, based on glutathione (GSH), plays a key role in endometrial detoxification reactions and has been proposed to be involved the pathogenesis endometriosis. This study was designed evaluate whether estradiol (E 2 ) proinflammatory cytokines have any effects expression of stromal cells (ESCs). Method Glutathione levels were measured utilizing high‐performance liquid chromatography following vitro culture treatment ESCs with estradiol, tumor necrosis...
Endometriosis is a common gynecological condition characterized by enhanced proliferation, adhesiveness, invasiveness, and survival of endometrial cells after retrograde menstruation. Originally identified as cytoskeletal regulatory kinase, p21-activated kinase 4 (Pak4) regulates diverse cellular activities that might be altered in the establishment progression endometriosis.The aim was to evaluate effects sex steroids proinflammatory cytokines on Pak4 expression along with functional change...
Objective Nuclear factor kappa-B (NF-κB) is a critical proinflammatory regulator that has been suggested to play pivotal role in the pathogenesis and pathophysiology of endometriosis. In present study, we aimed evaluate whether expression NF-κB p65 subunit increased eutopic endometrium and/or adenomyosis nodule women with adenomyosis. Methods Thirty-three histologically confirmed after laparoscopic or transabdominal hysterectomy were recruited. Women carcinoma situ uterine cervix without...