A5088109807- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- 14-3-3 protein interactions
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Cancer and Skin Lesions
- Ubiquitin and proteasome pathways
- Chromatin Remodeling and Cancer
- Neuroblastoma Research and Treatments
- 3D Printing in Biomedical Research
- Cancer Immunotherapy and Biomarkers
- Breast Implant and Reconstruction
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Multiple Myeloma Research and Treatments
- Phagocytosis and Immune Regulation
UNSW Sydney
2016-2025
Cancer Institute of New South Wales
2022-2025
Children's Cancer Institute Australia
2022-2025
Garvan Institute of Medical Research
2016-2024
The Kinghorn Cancer Centre
2016-2024
Sydney Children's Hospital
2024
Cancer Institute (WIA)
2024
The University of Sydney
2023
St Vincent's Clinic
2016-2022
Royal Derby Hospital
2005
Abstract Subcutaneous mastectomy has been performed on 98 patients with primary breast cancer. Eighty-four have undergone reconstruction using a silicone prosthesis. The overall complication rate low. rates of local recurrence and survival are similar to those in undergoing simple mastectomy.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome highly metastatic KPC (
Abstract Background Diffuse midline glioma, characterised by H3K27 alteration (DMG), is the predominant high-grade glioma in children. It commonly originates brainstem, yet effective treatments for these patients remain elusive. Methods To identify novel therapies DMG, we conducted high-throughput drug screens (HTS) using biologically active, clinically approved compounds against DMG neurospheres. Multiple primary cultures were utilised conjunction with vitro cytotoxicity and clonogenic...
Abstract Background Factors that drive the development of diffuse midline gliomas (DMG) are unknown. Our study aimed to determine prevalence pathogenic/likely pathogenic (P/LP) germline variants in pediatric patients with DMG. Methods We assembled an international cohort 252 DMG, including intrinsic pontine glioma (n=153), whole genome or exome sequencing. Results identified P/LP cancer predisposition genes 7.5% (19/252) patients. Tumor profiles differed, absence somatic drivers PI3K/mTOR...
Abstract Microdochectomy has been the accepted treatment for single-duct nipple discharge. Review of 97 consecutive patients undergoing microdochectomy between 1980 and 1987 revealed a total eight with ductal carcinoma in situ. All these had pre-operative mammography, results which were highly suspicious malignancy six patients. Tiny foci situ found two normal mammograms. We suggest an expectant policy cases where mammogram is normal, omitting routine microdochectomy.
Breast cancers display phenotypic and functional heterogeneity several lines of evidence support the existence cancer stem cells (CSCs) in certain breast cancers, a minor population capable tumor initiation metastatic dissemination. Identifying factors that regulate CSC phenotype is therefore important for developing strategies to treat disease. The Inhibitor Differentiation Protein 1 (Id1) its closely related family member 3 (Id3) (collectively termed Id) are expressed by diversity required...
The amino acid L-proline exhibits growth factor-like properties during development - from improving blastocyst to driving neurogenesis in vitro. Addition of 400 μM self-renewal medium drives naïve mouse embryonic stem cells (ESCs) early primitive ectoderm-like (EPL) a transcriptionally distinct primed or partially pluripotent state. EPL retain expression pluripotency genes, upregulate ectoderm markers, undergo morphological change and have increased cell number. These changes are facilitated...
Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing lineage-specification genes across diverse cellular lineages. ID4 is a key regulator mammary stem cells; however, the mechanism by which it achieves this unclear. Here, we show that has cell autonomous role in preventing myoepithelial basal cells organoids and vivo. positively regulates proliferative negatively involved function. Mass spectrometry reveals interacts bHLH protein HEB,...
Neuroblastoma is a deadly childhood cancer arising in the developing sympathetic nervous system. High-risk patients are currently treated with intensive chemotherapy, which curative only 50% of children and leaves some surviving life-long side effects. microRNAs (miRNAs) critical regulators neural crest development deregulated during neuroblastoma tumorigenesis, making miRNA-based drugs an attractive therapeutic avenue. A functional screen >1,200 miRNA mimics was conducted cell lines to...
We have exploited islet-associated macrophages (IAMs) as a model of resident macrophage function, focusing on more physiological conditions than the commonly used extremes M1 (inflammation) versus M2 (tissue remodeling) polarization. Under steady state, murine IAMs are metabolically poised between aerobic glycolysis and oxidative phosphorylation, thereby exert brake glucose-stimulated insulin secretion (GSIS). This is underpinned by epigenetic remodeling via regulated histone demethylase...
Between June 1979 and December 1984, 49,573 women (study population) between the ages of 45 64 years living in one health district were invited to attend breast self-examination sessions as part DHSS 'UK Trial Early Detection Breast Cancer'. Of 50.2 per cent attended for education. A total 319 cancers diagnosed study population during this period. The tumour characteristics, patient prognostic groups survival have been compared with a control consisting consecutive immediately before start...
Abstract Background Basal-like breast cancer (BLBC) is a poorly characterised, heterogeneous disease. Patients are diagnosed with aggressive, high-grade tumours and often relapse chemotherapy resistance. Detailed understanding of the molecular underpinnings this disease essential to development personalised therapeutic strategies. Inhibitor differentiation 4 (ID4) helix-loop-helix transcriptional regulator required for mammary gland development. ID4 overexpressed in subset BLBC patients,...
The basic helix-loop-helix (bHLH) transcription factors inhibitor of differentiation 1 (Id1) and 3 (Id3) (referred to as Id) have an important role in maintaining the cancer stem cell (CSC) phenotype triple-negative breast (TNBC) subtype. In this study, we aimed understand molecular mechanism underlying Id control CSC exploit it for therapeutic purposes. We used two different TNBC tumor models marked by either depletion or Id1 expression order identify targets using a combinatorial analysis...
Abstract The tumour stroma regulates nearly all stages of carcinogenesis. Stromal heterogeneity in human triple-negative breast cancers (TNBCs) remains poorly understood, limiting the development stromal-targeted therapies. Single cell RNA-sequencing five TNBCs revealed two cancer-associated fibroblast (CAF) and perivascular-like (PVL) subpopulations. CAFs clustered into states, first with features myofibroblasts second characterised by high expression growth factors immunomodulatory...
Abstract Diffuse Midline Glioma (DMG) is an incurable pediatric brain tumor thought to originate from oligodendrocyte precursor cells in midline structures. The RNA modification N6-methyladenosine (m6A) plays important role stability and critical neuronal stem-cell self-renewal differentiation. We therefore sought investigate m6A as a therapeutic target DMG. Moreover, targeting the epitranscriptome has shown promise treatment of other cancers, several small-molecule inhibitors writers...