A5043649111- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Lysosomal Storage Disorders Research
- Galectins and Cancer Biology
- Diabetes Management and Research
- Immune cells in cancer
- Ecology and Vegetation Dynamics Studies
- Wildlife Ecology and Conservation
- Phagocytosis and Immune Regulation
- Glycosylation and Glycoproteins Research
- Animal Ecology and Behavior Studies
- Cellular transport and secretion
The University of Sydney
2021-2025
Abstract O -Fucosylation plays crucial roles in various essential biological events. Alongside the well-established -fucosylation of epidermal growth factor-like repeats by protein -fucosyltransferase 1 (POFUT1) and thrombospondin type POFUT2, we recently identified a on elastin microfibril interface (EMI) domain Multimerin-1 (MMRN1). Here, using AlphaFold2 screens, co-immunoprecipitation, enzymatic assays combined with mass spectrometric analysis CRISPR–Cas9 knockouts, demonstrate that...
We have exploited islet-associated macrophages (IAMs) as a model of resident macrophage function, focusing on more physiological conditions than the commonly used extremes M1 (inflammation) versus M2 (tissue remodeling) polarization. Under steady state, murine IAMs are metabolically poised between aerobic glycolysis and oxidative phosphorylation, thereby exert brake glucose-stimulated insulin secretion (GSIS). This is underpinned by epigenetic remodeling via regulated histone demethylase...
Human commensal species are thought to depend so closely on resources provided by humans that they effectively ‘natives' of urban environments. However, while their adaptations existence well understood, ecology and habitat choices have not been examined. This study investigated the preferences archetypal species, invasive black rat Rattus rattus , at urban–bushland interface in Sydney, Australia, modelled results using isodar analysis. Unexpectedly, we found evidence rats perceived bushland...
Abstract Pancreatic β-cells in the islets of Langerhans are key to maintaining glucose homeostasis, by secreting peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), that have recently been considered intrinsic structures and proteins regulate granule maturation, trafficking, secretion. Previously, studies identified a handful novel ISG-associated using different separation techniques. Here, this study combines an optimized ISG isolation...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr">Pancreatic b-cells in the <i>Islets of Langerhans</i> are key to maintaining glucose homeostasis, by secreting peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), that have recently been considered intrinsic structures and proteins regulate granule maturation, trafficking, secretion. Previously, studies identified a handful novel ISG-associated using...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr">Pancreatic b-cells in the <i>Islets of Langerhans</i> are key to maintaining glucose homeostasis, by secreting peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), that have recently been considered intrinsic structures and proteins regulate granule maturation, trafficking, secretion. Previously, studies identified a handful novel ISG-associated using...
Pancreatic β-cells in the Islets of Langerhans are key to maintaining glucose homeostasis, by secreting peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), that have recently been considered intrinsic structures and proteins regulate granule maturation, trafficking, secretion. Previously, studies identified a handful novel ISG-associated using different separation techniques. Here, this study combines an optimized ISG isolation technique mass...