A5055197182- Gut microbiota and health
- Animal Nutrition and Physiology
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Diet and metabolism studies
- RNA modifications and cancer
- Probiotics and Fermented Foods
- Circular RNAs in diseases
- Odor and Emission Control Technologies
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Dialysis and Renal Disease Management
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory Bowel Disease
- Nutrition and Health in Aging
- Meat and Animal Product Quality
- Immune cells in cancer
- PI3K/AKT/mTOR signaling in cancer
- Peroxisome Proliferator-Activated Receptors
- Seaweed-derived Bioactive Compounds
Chinese Academy of Agricultural Sciences
2016-2024
Institute of Animal Sciences
2016-2023
Jiaxing University
2021-2023
Genome Institute of Singapore
2015-2022
Agency for Science, Technology and Research
2015-2022
University of Michigan
2022
Chinese University of Hong Kong
2021
Chinese University of Hong Kong, Shenzhen
2021
National University Cancer Institute, Singapore
2020
National University of Singapore
2020
Relapse to anti-HER2 monoclonal antibody (mAb) therapies, such as trastuzumab in HER2+ breast cancer (BC), is associated with residual disease progression due resistance therapy. Here, we identify interferon-γ inducible protein 16 (IFI16)-dependent STING signaling a significant determinant of responses BC. We show that down-regulation immune-regulated genes (IRG) specifically poor survival HER2+, but not other BC subtypes. Among IRG, IFI16 identified direct target EZH2, the underexpression...
Significance Colorectal cancer patients often relapse due to resistance chemotherapy. The tumor microenvironment is known contribute aggressiveness and chemoresistance, but the underlying mechanisms remain elusive. In current study, we have shown that cancer-associated fibroblasts (CAFs) which are present in can greatly promote of colorectal cells low-oxygen condition (hypoxia), CAFs-secreted growth factor TGF-β2 induce strong expression GLI2 , a gene therapy. As such, therapeutic targeting...
N6-methyladenosine (m6A) governs the fate of RNAs through m6A readers. Colorectal cancer (CRC) exhibits aberrant modifications and expression regulators. However, how readers interpret oncogenic methylome to promote malignant transformation remains be illustrated.YTH RNA binding protein 1 (Ythdf1) knockout mouse was generated determine effect Ythdf1 in CRC tumorigenesis vivo. Multiomic analysis RNA-sequencing, methylated immunoprecipitation sequencing, YTHDF1 proteomics were performed...
Caffeic acid (CA) is one of the major phenolic acids coffee with multiple biological activities. Our previous study found that 500 mg/kg chlorogenic (CGA) had potential capacity alleviating colonic inflammation. Moreover, CGA can be degraded into caffeic by gut microbiota in colon. Therefore, we hypothesize CA exert protective effects on To test hypothesis, 251 was supplemented to DSS-induced colitis mice. The results showed treatment recovered disease activity index (DAI), colon length, and...
The purpose of the current study was to investigate effect dietary dihydroquercetin (DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were given DHQ (3 g kg-1) throughout study, starting 14 days prior DSS treatment for 1 week followed by 2 without DSS. results showed that restored DSS-induced disease activity index (DAI), colon length and histopathology scores tissue. Additionally, with reduced pro-inflammatory cytokine levels, enhanced level IL-10 serum....
Metastatic tumour recurrence due to failed treatments remains a major challenge of breast cancer clinical management. Here we report that interleukin-1 receptor-associated kinase 1 (IRAK1) is overexpressed in subset cancers, particular triple-negative (TNBC), where it acts drive aggressive growth, metastasis and acquired resistance paclitaxel treatment. We show IRAK1 overexpression confers TNBC growth advantage through NF-κB-related cytokine secretion metastatic cells exhibit gain...
Colitis, a chronic inflammatory bowel disease, is characterized by bloody diarrhea and inflammation in the colon. Lonicera hypoglauca (“Shanyinhua” Chinese) Scutellaria baicalensis (“Huangqin” are two traditional Chinese medicinal plants rich polyphenols, such as chlorogenic acid (CGA) baicalin (BA), with effects of anti-inflammation antioxidation. However, it remains unknown whether extracts from L. S. (LSEs) could mitigate colonic inflammation. In present study, ICR mice (22.23 ± 1.65 g)...
Pectin is a heteropolysaccharide that acts as an intestinal immunomodulator, promoting development and regulating flora in the gut. However, relevant mechanisms remain obscure. In this study, pigs were fed corn-soybean meal-based diet supplemented with either 5% microcrystalline cellulose (MCC) or pectin for 3 weeks, to investigate metabolites anti-inflammatory properties of jejunum.The results showed dietary supplementation improved integrity (Claudin-1, Occludin) inflammatory response...
Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency it as an anti-tumor agent. However, a biological macromolecule with bidirectional immune regulation, immunological enhancement effects THP on macrophages its underlying mechanisms are still largely unknown. In present study, was prepared characterized, then effect Raw264.7 cell activation investigated....
Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for recurrence in these individuals remains poorly understood. Here, we demonstrate that RASAL2, which encodes RAS-GTPase–activating protein (RAS-GAP), is functional target anti-invasive microRNA-203 overexpressed subset or estrogen receptor–negative (ER-negative) tumors. As opposed to luminal B ER-positive cancers, RASAL2 has been shown act as RAS-GAP tumor...
Oxidative stress, one of the most common biological dysfunctions, is usually associated with pathological conditions and multiple diseases in humans animals. Chinese olive fruit ( Canarium album L.) extracts (OE) are natural plant rich polyphenols (such as hydroxytyrosol, HT) antioxidant, anti-hyperlipidemia, anti-inflammatory potentials. This study was conducted to investigate antioxidant capacity OE supplementation its related molecular mechanism mice. Mice (25.46 ± 1.65 g) were treated...
Dysregulated lipid metabolism is a key pathology in metabolic diseases and the liver critical organ for metabolism. The gut microbiota has been shown to regulate hepatic host. However, underlying mechanism by which influences not elucidated. Here, depletion mouse model was constructed with an antibiotics cocktail (Abx) study through intestinal regulates high-fat diet (HFD)-fed mice. Our results showed that Abx treatment effectively eradicated these Microbiota reduced body weight fat...
H19 is a well-characterized Long noncoding RNA (lncRNA) that has been proven to promote myoblast differentiation in humans and mice. However, its mechanism of action still not fully interpreted.Using RT-qPCR, we examined levels various tissues from 1-week, 1-month, 6-month 36-month old male cattle (i.e., newborn, infant, young adult). The protein mRNA MyoG, MyHC, Sirt1 FoxO1 the satellite C2C12 cells with an silencing or overexpression vector were respectively detected using western blot...
Abstract A number of emerging studies suggest that air pollutants such as hydrogen sulfide (H 2 S) and ammonia (NH 3 ) may cause a decline in spermatozoa motility. The impact underlying mechanisms are currently unknown. Boar ( vitro peripubertal male mice vivo were exposed to H S and/or NH evaluate the on Na 4 Cl reduced motility boar vitro. disrupted multiple signaling pathways including decreasing + /K ATPase activity protein kinase B (AKT) levels, activating Adenosine 5′-monophosphate...
Alginate oligosaccharides (AOS), belonging to the class of functional marine oligosaccharides, are low-molecular polymers linked by β-1,4-mannuronic acid (M) and α-1,4-guluronic (G), which could be classically obtained enzymatic hydrolysis alginate. With low viscosity good water solubility, as well anti-oxidant, immune regulation, anti-bacterial anti-inflammatory activities, AOS have been widely used in medical science food, green agriculture other fields. As new bio-feed additives, broad...
HER2-targeted therapy has yielded a significant clinical benefit in patients with HER2+ breast cancer, yet disease relapse due to intrinsic or acquired resistance remains challenge the clinic. Here, we show that protein phosphatase 2A (PP2A) regulatory subunit PPP2R2B is crucial determinant of anti-HER2 response. downregulated substantial subset cancers, which correlates poor outcome and therapies. EZH2-mediated histone modification accounts for downregulation, resulting sustained...
Chemically protected sodium butyrate (CSB) is a new kind of butyrate. Our previous study found that 1,000 mg/kg CSB had the potential capacity improving growth performance and promoting early development small intestine in broilers. This aimed to investigate effect long-term antibiotics or supplementation for intestinal microflora dynamical regulation One hundred ninety-two 1-day-old Arbor Acres male broilers were randomly allocated into 3 dietary treatment (8 replicates per treatment) fed...
High concentrations of atmospheric ammonia are one the key environmental stressors affecting broiler production performance, which causes remarkable economic losses as well potential welfare problems industry. Previous reports demonstrated that high levels altered body fat distribution and meat quality broilers. However, molecular mechanisms metabolic pathways in breast muscle by ambient exposure on broilers still unknown. This study utilized RNA-Seq to compare transcriptomes muscles...
Chlorogenic acid (CGA) is an important source of phenolic acids with multiple health functions such as antioxidation, anti-inflammation, and free radical scavenging effects. This study aimed to investigate whether the nuclear factor erythroid 2-related 2 (Nrf-2)/HO-1 pathway played a role in CGA ameliorating DSS-induced colitis mice. 500 mg/kg (high chlorogenic acid, HCGA) 250 (low LCGA) supplementation could alleviate symptoms related mechanisms. qPCR results indicated that HCGA treatment...