A5078149133- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Prostate Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Radiation Effects in Electronics
- Nuclear Physics and Applications
- Image Processing and 3D Reconstruction
- Image Enhancement Techniques
- Radiative Heat Transfer Studies
- Smart Agriculture and AI
- Organic Light-Emitting Diodes Research
- Conducting polymers and applications
- Plant Pathogens and Fungal Diseases
- Plant tissue culture and regeneration
- Seed Germination and Physiology
- Carbon Nanotubes in Composites
- Soft Robotics and Applications
- Advanced Image and Video Retrieval Techniques
- Advanced Optical Sensing Technologies
- Polymer Nanocomposite Synthesis and Irradiation
- Organic Electronics and Photovoltaics
University of Wollongong
2014-2025
Prince of Wales Hospital
2024-2025
The University of Sydney
2019-2020
Ingham Institute
2015-2019
Max Planck Institute for the Physics of Complex Systems
2016
Institute of Nuclear Physics, Polish Academy of Sciences
2016
Universitätsklinikum Erlangen
2016
Institut de Mathématiques de Bordeaux
2016
Université de Bordeaux
2016
Centre National de la Recherche Scientifique
2016
Purpose: The pursuit of real‐time image guided radiotherapy using optimal tissue contrast has seen the development several hybrid magnetic resonance imaging (MRI)‐treatment systems, high field and low field, inline perpendicular configurations. As part a new MRI‐linac program, an MRI scanner was integrated with linear accelerator to enable investigations coupled system. This work describes results from prototype experimental system demonstrate feasibility MR‐linac. Methods: magnet is 1.5 T...
Abstract Purpose We introduce the next generation of “MagicPlate” 2D monolithic pixelated semiconductor detectors – MagicPlate‐976 (MP976). It features a larger array area, higher spatial resolution, and does not require external triggering. perform comprehensive characterization for small‐field steep‐dose‐gradient dosimetry applications in radiation therapy focusing on x‐ray beams used stereotactic treatments. Methods The MP976, developed by Centre Medical Radiation Physics, consists 976...
Purpose: This paper presents initial experimental results from a prototype of high dose rate (HDR) BrachyView, novel in‐body source tracking system for HDR brachytherapy based on multipinhole tungsten collimator and resolution pixellated silicon detector array. The probe its associated position estimation algorithms are validated comprehensive evaluation the accuracy capabilities is presented. Methods: moved through sequence positions in prostate phantom, various displacements x , y z . For...
Abstract A new printable organic semiconducting material combination as a tissue equivalent photodetector for indirect X‐ray detection is demonstrated in this work. The device exhibits higher optical‐to‐electrical conversion efficiency than any other reported systems photodetection while also operating efficiently with zero applied bias. Complete detectors fabricated by coupling the photodiode plastic scintillator are among first flexible and fully capable of without external response to...
There is growing interest in the development of novel materials and devices capable ionizing radiation detection for medical applications. Organic semiconductors are promising candidates to meet demands modern detectors, such as low manufacturing costs, mechanical flexibility, a response equivalent human tissue. However, organic have typically been employed applications that convert energy photons into high current densities, example, solar cells LEDs, thus existing design rules must be...
Spectroscopy-based photon-counting detector systems, Medipix, have many applications in medicine. Medipix detectors benefit from providing energy information as well high spatial resolution. In this article, a review of technology applied to medicine and imaging techniques are presented. The has been used develop quality assurance (QA) measurement devices radiation-based treatments. A gamma camera system for radiotherapy developed measure dose delivered prostate treatments real-time....
In this study we develop and characterise a six degree-of-freedom (6 DoF) robotic motion system for quality assurance of real-time image-guided radiotherapy techniques. The consists commercially available arm, an acrylic phantom with embedded Calypso markers, custom base plate to mount the robot treatment couch, control software implementing appropriate sequence transformations reproduce measured tumour traces. was evaluated in terms set-up trace repeatability, static localization accuracy...
HDR BrachyView is a novel in-body dosimetric imaging system for real-time monitoring and verification of the source position in high dose rate (HDR) prostate brachytherapy treatment. It based on high-resolution pixelated detector array with semi-cylindrical multi-pinhole tungsten collimator designed to fit inside compact rectal probe, able resolve 3D maximum error 1.5 mm. This paper presents an evaluation additional that will be delivered patient as result backscatter radiation from...
Spatially fractionated ultra-high-dose-rate beams used during microbeam radiation therapy (MRT) have been shown to increase the differential response between normal and tumour tissue. Quality assurance of MRT requires a dosimeter that possesses tissue equivalence, high tolerance spatial resolution. This is currently an unsolved challenge. work explored use 500 nm thick organic semiconductor for dosimetry on Imaging Medical Beamline at Australian Synchrotron. Three beam filters were irradiate...
Image guided radiotherapy (IGRT) with cone-beam computed tomography (CBCT) is limited by the sub-optimal soft-tissue contrast and spatial resolution of energy-integrating flat panel detectors (FPDs) which produce quasi-quantitative CT numbers. Spectral high photon-counting (PCDs) could improve tumor delineation enhancing contrast, resolution, dose-efficiency, number accuracy. This study presents first linac-mounted PCD. On journey to developing spectral for IGRT, planar image quality a PCD...
The choice of pinhole geometry is a critical factor in the performance pinhole-collimator-based source tracking systems for brachytherapy QA. In this work, an analytical model describing penetrative sensitivity single-cone collimator to photons emitted from point derived. Using existing models resolution and double-cone resolution, theoretical are quantitatively compared with those equivalent field view. Monte Carlo simulations single collimators using accurate 3D commercial high dose rate...
BrachyView is a novel in-body imaging system utilising high-resolution pixelated silicon detectors (Timepix) and pinhole collimator for brachytherapy source localisation. Recent studies have investigated various options real-time intraoperative dynamic dose treatment planning to increase the quality of implants. In previous proof-of-concept study, justification concept was shown, allowing next step whereby multiple active seeds are implanted into PMMA phantom simulate more realistic clinical...
The Australian MRI-Linac consists of a fixed horizontal photon beam combined with MRI. Commissioning required PDD and profiles measured in set-up using combination water tank measurements gafchromic film. To validate the methodology, were performed comparing gantry angle set to 0 90° on conventional linac. Results showed agreement within 2.0% for both film at relative acquired 0°. Profiles FWHM 1 mm. 0° curves indicates that methodology described can be used acquire necessary data lines...
A large area pixelated silicon array detector named “MP987” has been developed for in vivo dosimetry. The was to overcome the non-water equivalent response of EPID (Electronic Portal Imaging Device) dosimetry systems, due shortfalls extensive corrections required. detector, readout system and software have all custom designed be operated independently from linac with secured directly above EPID, used combination 6 MV imaging system. Dosimetry characterisation measurements percentage depth...
BrachyView is a novel in-body imaging system developed with the objective to provide real-time intraoperative dosimetry for low dose rate (LDR) prostate brachytherapy treatments. Seed positions can be reconstructed after implantation by means of high-resolution pinhole gamma camera. The obtained dataset then combined conventional trans-rectal ultrasound (TRUS) locate effective source position within volume. This study presents comparison two data sets containing 96 and 98 I-25 sources...
Purpose Tumor motion during radiotherapy can cause a reduction in target dose coverage and an increase healthy tissue exposure. is not strictly translational often exhibits complex six degree‐of‐freedom (6DoF) rotational motion. Although the dosimetric impact of prostate tumor well investigated, 6DoF has only been studied with simulations or reconstruction. This study aims to experimentally quantify error caused by The experiment was designed test hypothesis that would larger errors than...
A prototype in-body gamma camera system with integrated trans-rectal ultrasound (TRUS) and associated real-time image acquisition analysis software was developed for intraoperative source tracking in high dose rate (HDR) brachytherapy. The accuracy temporal resolution of the validated experimentally using a deformable tissue-equivalent prostate gel phantom full clinical HDR treatment plan. BrachyView able to measure 78% 200 positions an better than 1 mm. minimum time 0.28 s/frame required...
Abstract Microdosimetry is a useful method to evaluate the relative biological effectiveness (RBE) as well dose equivalent of any mixed radiation field without prior knowledge type charged particles and their spectra. The need portable, user friendly devices for microdosimetric Quality Assurance measurements in particle therapy are greatly preferable avoid sophisticated setup time-consuming data analysis. Currently, ability perform restricted those with extensive electronics involved...
Purpose: To evaluate the significance of fractionated administration thalidomide combined with γ-ray irradiation in terms local tumor response and lung metastatic potential, referring to intratumor quiescent (Q) cells.Materials/methods: B16-BL6 melanoma tumor-bearing C57BL/6 mice were continuously given 5-bromo-2'deoxyuridine (BrdU) label all proliferating (P) cells.The then received after treatment through a single or 2 consecutive daily intraperitoneal administrations up total dose 400...
Conclusions: The M512 is expected to be a valuable tool for 2D dose-mapping in MRI-linac facilities, especially considering its closely pitched diodes detecting changes beam profiles magnetic field.Future work includes experimental validation of simulation results using custom designed permanent magnet system.
Purpose or Objective: Catheter reconstruction errors, wrong indexer length and misidentified first dwell position are among the most common medical events related to highdose-rate brachytherapy (HDR-BT) treatment, reported in United States by Nuclear Regulatory Commission.The purpose of this study is a feasibility analysis for detection such based on electromagnetic tracking (EMT). Material Methods:In phantom-based experiment series, swap catheters displacement (Δl = 0, 1, 2, 3, 4, 5 6 mm)...