A5020880987- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Advanced Vision and Imaging
- Robotics and Sensor-Based Localization
- Radiopharmaceutical Chemistry and Applications
- Optical Imaging and Spectroscopy Techniques
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiation Dose and Imaging
- Particle Detector Development and Performance
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Medical Imaging and Analysis
- Soft Robotics and Applications
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Neuroscience and Neuropharmacology Research
- Plant nutrient uptake and metabolism
- Advanced Image Processing Techniques
- Cerebrovascular and Carotid Artery Diseases
The University of Sydney
2015-2024
Cooperative Trials Group for Neuro-Oncology
2017-2018
University of California, Davis
2014-2017
Advanced Bioscience Laboratories (United States)
2016
Hudson Institute
2016
John Wiley & Sons (United States)
2016
Motion Control (United States)
2013
Westmead Hospital
2001-2002
UNSW Sydney
2002
Positron emission tomography (PET) plays an increasingly important role in research and clinical applications, catalysed by remarkable technical advances a growing appreciation of the need for reliable, sensitive biomarkers human function health disease. Over last 30 years, large amount physics engineering effort PET has been motivated dominant application during that period, oncology. This led to developments such as PET/CT, whole-body PET, 3D accelerated statistical image reconstruction,...
High-resolution positron emission tomography (PET) imaging of conscious, unrestrained laboratory animals presents many challenges. Some form motion correction will normally be necessary to avoid artefacts in the reconstruction. The aim current work was develop and evaluate a tracking system potentially suitable for use small animal PET. This is based on commercially available stereo-optical MicronTracker S60 which we have integrated with Siemens Focus-220 microPET scanner. We present...
Positron emission tomography (PET) is a non-invasive molecular imaging technique using positron-emitting radioisotopes to study functional processes within the body. High resolution PET scanners designed for rodents and non-human primates are now commonplace in preclinical research. Brain this context, with motion compensation, can potentially enhance usefulness of by avoiding confounds due anaesthetic drugs enabling freely moving animals be imaged during normal evoked behaviours. Due...
We propose a method to compensate for six degree-of-freedom rigid motion in helical CT of the head. The is demonstrated simulations and scans performed on 16-slice scanner. Scans Hoffman brain phantom were acquired while an optical tracking system recorded bed phantom. Motion correction was by restoring projection consistency using data from system, reconstructing with iterative fully 3D algorithm. accuracy evaluated comparing reconstructed images stationary reference scan. also investigated...
Noninvasive functional imaging of awake, unrestrained small animals using motion-compensation removes the need for anesthetics and enables an animal's behavioral response to stimuli or administered drugs be studied concurrently with imaging. While feasibility motion-compensated radiotracer awake rodents marker-based optical motion tracking has been shown, markerless would avoid risk marker detachment, streamline experimental workflow, potentially provide more accurate pose estimates over a...
Patient motion can cause image artifacts in single photon emission computed tomography despite restraining measures. Data-driven detection and correction of be achieved by comparison acquired data with the forward projections. This enables brain locations to estimated correctly incorporated a three-dimensional (3-D) reconstruction algorithm. Digital physical phantom experiments were performed explore practical aspects this approach. Noisy simulation modeling multiple 3-D patient head...
Positron emission tomography (PET) is a cross-sectional, functional imaging modality that has recently become available to the horse. The use of 18 F-sodium fluoride (18 F-NaF), PET bone tracer, not previously been reported in this species.To assess feasibility F-NaF equine distal limb and explore possible applications horse comparison with other modalities.Exploratory descriptive study involving three research horses.Horses were placed under general anaesthesia prior intravenous (i.v.)...
Abstract Objective To further develop and refine an Emergency Department (ED) in‐patient admission prediction model using machine learning techniques. Methods This was a retrospective analysis of state‐wide ED data from New South Wales, Australia. Six classification algorithms (Bayesian networks, decision trees, logistic regression, naïve Bayes, neural networks nearest neighbour) five feature selection techniques (none, manual, correlation‐based, information gain wrapper) were examined....
Shape memory alloy (SMA) has been adopted in medical robotics due to its high power density, compactness, and imager compatibility. However, use clinical applications remains limited low actuation bandwidth the lack of proper system integration approaches, leading poor control accuracy repeatability. In this article, we report design, modeling, characterization a high-performance SMA actuator for real-time application. It uses nichrome wire fast heating forced air convection active cooling...
Objective. Cerebral CT perfusion (CTP) imaging is most commonly used to diagnose acute ischaemic stroke and support treatment decisions. Shortening CTP scan duration desirable reduce the accumulated radiation dose risk of patient head movement. In this study, we present a novel application stochastic adversarial video prediction approach acquisition time.Approach. A variational autoencoder generative network (VAE-GAN) were implemented in recurrent framework three scenarios: predict last 8...
Even with head restraint, small movements can occur during data acquisition in emission tomography that are sufficiently large to result detectable artifacts the final reconstruction. Direct measurement of motion be cumbersome and difficult implement, whereas previous attempts use measured projection for correction have been limited simple translation orthogonal projection. A fully three-dimensional (3-D) algorithm is proposed estimates patient orientation based on motion-corrupted data,...
Positron emission tomography (PET) is a highly sensitive, noninvasive imaging technique for quantifying biological functions of tissues. However, at the time this study, PET applications had not been reported in horse. The aim exploratory study was to determine whether portable high‐resolution scanner could be used image equine distal limb. Images front feet and fetlocks three research horses, with known lesions localized limbs, were acquired under general anesthesia after administration 18...
Abstract Soil salinity is a global environmental challenge for crop production. Understanding the uptake and transport properties of salt in plants crucial to evaluate their potential growth high soils as basis engineering varieties with increased tolerance. Positron emission tomography (PET), traditionally used medical animal imaging applications assessing quantifying dynamic bio-distribution molecular species, has provide useful measurements dynamics an intact plant. Here we report on...
Purpose Prospective motion correction is arguably the “silver bullet” solution for magnetic resonance imaging (MRI) studies impacted by motion, applicable to almost any pulse sequence and immune from spin history artifacts introduced a moving object. In prospective correction, field gradients radio frequency waveforms are adjusted in real time response measured head so as maintain stationary reference frame relative scanner. Vital this approach accurate rapidly sampled pose measurements,...
Dose reduction in cerebral CT perfusion (CTP) imaging is desirable but accompanied by an increase noise that can compromise the image quality and accuracy of image-based haemodynamic modelling used for clinical decision support acute ischaemic stroke. The few reported methods aimed at denoising low-dose CTP images lack practicality considering only small sections brain or being computationally expensive. Moreover, prediction infarct penumbra size location-the chief means treatment...
Small animal positron emission tomography (PET) is a powerful method for studying the molecular origins of debilitating brain disorders such as dementia, depression and schizophrenia. However, its full potential in investigations has not yet been realized due to use anesthesia avoid motion artifacts. In spite preventing motion, anesthestics have propensity alter function compared unanesthetized state. Use also precludes an animal's behavior concurrently with imaging. Methods enabling PET...
Positron emission tomography (PET) is an important in vivo molecular imaging technique for translational research. Imaging unanaesthetized rats using motion-compensated PET avoids the confounding impact of anaesthetic drugs and enables animals to be imaged during normal or evoked behaviour. However, there little published data on nature rat head motion inform design suitable marker-based motion-tracking set-ups brain imaging—specifically, that afford close uninterrupted tracking. We...
Motion-compensated brain imaging can dramatically reduce the artifacts and quantitative degradation associated with voluntary involuntary subject head motion during positron emission tomography (PET), single photon computed (SPECT) (CT). However, motion-compensated protocols are not in widespread clinical use for these modalities. A key reason this seems to be lack of a practical tracking technology that allows smooth reliable integration setting. We seek address problem by investigating...
This paper describes a potential method to detect changes in cerebral blood flow (CBF) using electrocardiography (ECG) signals, measured across scalp electrodes with reference the same signal chest-a metric we term Electrocardiography Brain Perfusion index (EBPi). We investigated feasibility of EBPi monitor CBF response specific tasks. Twenty healthy volunteers wore head-mounted device and electroencephalography (EEG) during tasks known alter CBF. Transcranial Doppler (TCD) ultrasound...
Line of response (LOR) rebinning is an event-based motion-correction technique for positron emission tomography (PET) imaging that has been shown to compensate effectively rigid motion. It involves the spatial transformation LORs motion during scan, as measured by a tracking system. Each motion-corrected event then recorded in sinogram bin corresponding transformed LOR. previously corrected must be normalized using normalization factor derived from original LOR, is, based on pair detectors...
'Open-field' PET, in which an animal is free to move within enclosed space during imaging, a very promising advance for neuroscientific research. It provides key advantage over conventional imaging under anesthesia by enabling functional changes the brain be correlated with animal's behavioural response environmental or pharmacologic stimuli. Previously we have demonstrated feasibility of open-field rats using motion compensation techniques applied commercially available PET scanner....