A5009866173- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Luminescence Properties of Advanced Materials
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced Radiotherapy Techniques
- Digital Imaging in Medicine
- Fault Detection and Control Systems
- Optical Imaging and Spectroscopy Techniques
- Radiation Dose and Imaging
- Face recognition and analysis
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- bioluminescence and chemiluminescence research
- Machine Learning in Materials Science
- Advanced X-ray and CT Imaging
University of California, Davis
2017-2024
UC Davis Health System
2022
University of America
2021
The collaboration of Yale, the University California, Davis, and United Imaging Healthcare has successfully developed NeuroEXPLORER, a dedicated human brain PET imager with high spatial resolution, sensitivity, built-in 3-dimensional camera for markerless continuous motion tracking. It depth-of-interaction time-of-flight resolutions, along 52.4-cm transverse field view (FOV) an extended axial FOV (49.5 cm) to enhance sensitivity. Here, we present physical characterization, performance...
Thallium bromide (TlBr) and thallium chloride (TlCl) are semiconductor materials with high transparency to visible light, index of refraction, detection efficiency for gamma rays annihilation photons. This manuscript reports on measurements the light intensity timing response Čerenkov emitted in one 3 mm × 5 slab each these operated coincidence a lutetium fine silicate (LFS) crystal dimensions 20 mm. A
Total-body PET/CT images can be rendered to produce of a subject's face and body. In response privacy identifiability concerns when sharing data, we have developed validated workflow that obscures (defaces) in 3-dimensional volumetric data. <b>Methods:</b> To validate our method, measured facial before after defacing from 30 healthy subjects who were imaged with both [<sup>18</sup>F]FDG PET CT at either 3 or 6 time points. Briefly, embeddings calculated using Google's FaceNet, an analysis...
'Open-field' PET, in which an animal is free to move within enclosed space during imaging, a very promising advance for neuroscientific research. It provides key advantage over conventional imaging under anesthesia by enabling functional changes the brain be correlated with animal's behavioural response environmental or pharmacologic stimuli. Previously we have demonstrated feasibility of open-field rats using motion compensation techniques applied commercially available PET scanner....
We are building a high sensitivity preclinical PET/MRI insert using highly multiplexed light sharing PET module. Each module incorporates four 19 × arrays of 1 20 mm3 LYSO crystals with dual-ended DOI encoding readout, requiring 32 readout channels for positioning and eight timing. These constraints necessitate compact, robust electronics digitization. have characterized linearized time-over-threshold circuits based on these detector requirements. The allow channel density can digitize...
Objective.This work assessed the relationship between image signal-to-noise ratio (SNR) and total-body noise-equivalent count rate (NECR)-for both non-time-of-flight (TOF) NECR TOF-NECR-in a long uniform water cylinder 14 healthy human subjects using uEXPLORER PET/CT scanner.Approach.A TOF-NEC expression was modified for list-mode PET data, non-TOF TOF-NECR were compared datasets from scanned up to 12 h after radiotracer injection.Main results.The found be linearly proportional...
Preclinical positron emission tomography, combined with magnetic resonance imaging (PET/MRI), is increasingly used as a tool to simultaneously characterize functional processes in vivo. Many emerging preclinical applications, however, are limited by PET detection sensitivity, especially when generating short frames for quantitative studies. One such application dynamic multifunctional imaging, which probes multiple aspects of biological process, using relationships between the datasets...
Abstract Objective. This study investigates the potential of cloud-based serverless computing to accelerate Monte Carlo (MC) simulations for nuclear medicine imaging tasks. MC can pose a high computational burden—even when executed on modern multi-core servers. Cloud allows simulation tasks be highly parallelized and considerably accelerated. Approach. We investigate performance radioactive decays positron emission tomography using Amazon Web Service (AWS) Lambda platform first time in...
The NeuroEXPLORER (NX) system has recently been proposed for a high-resolution and high-sensitivity PET scanner dedicated brain research. A long axial field-of-view (FOV) of 50cm was used maximizing the sensitivity in region. Depth-of-interaction (DOI) modelling NX is necessary generating images compensate large angle effects caused by FOV.To minimize modifications on existing reconstruction algorithm to computational cost, listmode-based DOI compensation method (DOI mashing) developed. For...
Cerenkov luminescence (CL), optical radiation induced by PET radiotracers, has shown promise as a means to visualize tumor margins during surgery. However, detecting this faint signal under ambient lighting conditions represents major challenge. We have developed an light CL imaging system that uses sensitive detector, custom electronic control board, and LED illumination array. By gating both we demonstrated is possible image Cerenkov-emitting sources in perceptually well-lit room, without...
Normalization correction is a pre-requisite for accurate reconstruction of PET images. Uniform phantoms are often used to estimate normalization factors. While this approach can provide reliable results, the additional phantom-based scans reduce overall patient throughput. The main component in factors that may change over time crystal efficiencies. efficiencies affect both coincidence events and single events. Single data estimating A maximum-likelihood-based has been derived estimation...