A5047816435- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Radiation Detection and Scintillator Technologies
- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Atomic and Subatomic Physics Research
- MRI in cancer diagnosis
- Radiation Dose and Imaging
- Radiopharmaceutical Chemistry and Applications
- Digital Radiography and Breast Imaging
- Nuclear Physics and Applications
- Cardiac Imaging and Diagnostics
- Rheumatoid Arthritis Research and Therapies
- Gastrointestinal Tumor Research and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Medical Imaging and Pathology Studies
- COVID-19 Clinical Research Studies
- Orthopedic Infections and Treatments
- Gastrointestinal disorders and treatments
- Long-Term Effects of COVID-19
University of California, Davis
2016-2025
University of California Davis Medical Center
2015-2025
UC Davis Health System
2020-2025
UC Davis Comprehensive Cancer Center
2024
University of Wisconsin–Madison
2024
California State University, Sacramento
2023
Laboratoire d’Imagerie Biomédicale
2023
Harvard University
2000-2022
Gordon Center for Medical Imaging
2022
Massachusetts General Hospital
2022
Within the EXPLORER Consortium, construction of world’s first total-body PET/CT scanner has recently been completed. The 194-cm axial field view is sufficient to cover, for time, entire human adult body in a single acquisition more than 99% population and allows pharmacokinetic studies with frame durations as short 1 s. large increase sensitivity arising from coverage well increased solid angle detection at any point within whole-body <sup>18</sup>F-FDG PET be acquired unprecedented count...
The world’s first total-body PET scanner with an axial field of view (AFOV) 194 cm is now in clinical and research use at our institution. uEXPLORER PET/CT system the commercially available scanner. Here we present a detailed physical characterization this based on National Electrical Manufacturers Association (NEMA) NU 2-2018 along new set measurements devised to appropriately characterize AFOV. <b>Methods:</b> Sensitivity, count-rate performance, time-of-flight resolution, spatial image...
The world's first 194-cm-long total-body PET/CT scanner (uEXPLORER) has been built by the EXPLORER Consortium to offer a transformative platform for human molecular imaging in clinical research and health care. Its coverage ultra-high sensitivity provide opportunities more accurate tracer kinetic analysis studies of physiology, biochemistry, pharmacology. objective this study was demonstrate capability parametric quantify improvement image quality parameter estimation direct kernel...
We introduce multiple-organ objective segmentation (MOOSE) software that generates subject-specific, multiorgan using data-centric artificial intelligence principles to facilitate high-throughput systemic investigations of the human body via whole-body PET imaging. <b>Methods:</b> Image data from 2 PET/CT systems were used in training MOOSE. For noncerebral structures, 50 CT images used, 30 which acquired healthy controls (14 men and 16 women), 20 datasets oncology patients 6 women)....
The collaboration of Yale, the University California, Davis, and United Imaging Healthcare has successfully developed NeuroEXPLORER, a dedicated human brain PET imager with high spatial resolution, sensitivity, built-in 3-dimensional camera for markerless continuous motion tracking. It depth-of-interaction time-of-flight resolutions, along 52.4-cm transverse field view (FOV) an extended axial FOV (49.5 cm) to enhance sensitivity. Here, we present physical characterization, performance...
A simple methodology for the manufacture and calibration of polyacrylamide gel (PAG) magnetic resonance imaging (MRI) radiation dosimetry is presented to enable individuals undertake such work in a routine clinical environment. Samples PAG were irradiated using linear accelerator imaged 0.5 T (22 MHz) Philips Gyroscan MRI scanner. The mean spin-lattice relaxation rate was measured `turbo-mixed' sequence, consisting series pulses, each followed by acquisition train spin echoes. sensitivity...
OBJECTIVE. We report results from a pilot study aimed at optimizing the use of CT bidimensional measurements and 18F-FDG PET maximum standardized uptake values (SUVs-max) for determining response to prolonged imatinib mesylate treatment in patients with advanced gastrointestinal stromal tumors (GISTs).
The axial field of view (AFOV) the current generation clinical whole-body PET scanners range from 15–22 cm, which limits sensitivity and renders applications such as dynamic imaging or very low activities in cellular tracking studies, almost impossible. Generally, extending AFOV significantly increases count-rate performance. However, while maintaining detector thickness has significant cost implications. In addition, random coincidences, dead time, object attenuation may reduce scanner...
A 194-cm-long total-body positron emission tomography/computed tomography (PET/CT) scanner (uEXPLORER), has been constructed to offer a transformative platform for human radiotracer imaging in clinical research and healthcare. Its coverage exceptional sensitivity provide opportunities innovative studies of physiology, biochemistry, pharmacology. The objective this study is develop method perform ultrahigh (100 ms) temporal resolution dynamic PET by combining advanced image reconstruction...
The EXPLORER project aims to build a 2 meter long total-body PET scanner, which will provide extremely high sensitivity for imaging the entire human body. It possess range of capabilities currently unavailable state-of-the-art clinical scanners with limited axial field-of-view. huge number lines-of-response (LORs) poses challenge data handling and image reconstruction. objective this study is develop quantitative reconstruction method compare its performance current whole-body scanners....
Quantitative dynamic PET with compartmental modeling has the potential to enable multiparametric imaging and more accurate quantification as compared static imaging. Conventional methods for parametric commonly use a single kinetic model all image voxels neglect heterogeneity of physiological models, which can work well single-organ but may significantly compromise total-body on long axial field-of-view scanners. In this paper, we evaluate necessity voxel-wise strategies, including time...
Parametric imaging has been shown to provide better quantitation physiologically than SUV in PET. With the increased sensitivity from a recently developed total-body PET scanner, whole-body scans with higher temporal resolution become possible for dynamic analysis and parametric imaging. In this paper, we focus on deriving parameter k1 using compartmental modeling developing method acquire 18F-FDG images only first 90 s of postinjection scan data system. Methods: Dynamic projections were...
Our aim was to define a lower limit of reduced injected activity in delayed [
We have constructed a dedicated breast PET/CT scanner capable of high-resolution functional and anatomic imaging. Here, we present an initial characterization performance during patient <b>Methods:</b> The system consisted lutetium oxyorthosilicate–based dual–planar head PET camera (crystal size, 3 × 20 mm) 768-slice cone-beam CT. position the heads (separation height) could be adjusted for varying dimensions. For scanning, lay prone on specialized bed inserted single pendent through...
In 2005, 8 Imaging Response Assessment Teams (IRATs) were funded by the National Cancer Institute (NCI) as supplemental grants to existing NCI Centers. After discussion among IRATs regarding need for increased standardization of clinical and research PET/CT methodology, it became apparent that data acquisition processing approaches differ considerably centers. To determine variability in detail, a survey IRAT sites affiliates was performed. <b>Methods:</b> A 34-question instrument evaluating...
Positron emission tomography (PET) plays an increasingly important role in research and clinical applications, catalysed by remarkable technical advances a growing appreciation of the need for reliable, sensitive biomarkers human function health disease. Over last 30 years, large amount physics engineering effort PET has been motivated dominant application during that period, oncology. This led to developments such as PET/CT, whole-body PET, 3D accelerated statistical image reconstruction,...
With most of the T cells residing in tissue, not blood, developing noninvasive methods for vivo quantification their biodistribution and kinetics is important studying role immune response memory. This study presents first use dynamic positron emission tomography (PET) kinetic modeling measurement CD8
We introduce the Fast Algorithm for Motion Correction (FALCON) software, which allows correction of both rigid and nonlinear motion artifacts in dynamic whole-body (WB) images, irrespective PET/CT system or tracer. Methods: was corrected using affine alignment followed by a diffeomorphic approach to account nonrigid deformations. In steps, images were registered multiscale image alignment. Moreover, frames suited successful automatically estimated calculating initial normalized...
Tissue perfusion can be affected by physiology or disease. With the advent of total-body PET, quantitative measurement across entire body is possible. [