A5071668862- Gastric Cancer Management and Outcomes
- Ion Transport and Channel Regulation
- Medical Imaging Techniques and Applications
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Advanced X-ray and CT Imaging
- Membrane-based Ion Separation Techniques
- Intraperitoneal and Appendiceal Malignancies
- Esophageal Cancer Research and Treatment
- Planarian Biology and Electrostimulation
- Cardiac tumors and thrombi
- Solar-Powered Water Purification Methods
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Photosynthetic Processes and Mechanisms
- Herpesvirus Infections and Treatments
- Congenital Diaphragmatic Hernia Studies
- Lipoproteins and Cardiovascular Health
- Public Health and Environmental Issues
- Gastroesophageal reflux and treatments
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Head and Neck Cancer Studies
University of Helsinki
2019-2022
Harvard University
2007-2012
Dana-Farber Cancer Institute
2004-2012
Brigham and Women's Hospital
1988-2012
Dana-Farber Brigham Cancer Center
2010
Novartis (Switzerland)
2004
Oregon Health & Science University
2004
Fox Chase Cancer Center
2004
Helsinki University Hospital
2004
OBJECTIVE. We report results from a pilot study aimed at optimizing the use of CT bidimensional measurements and 18F-FDG PET maximum standardized uptake values (SUVs-max) for determining response to prolonged imatinib mesylate treatment in patients with advanced gastrointestinal stromal tumors (GISTs).
Abstract Key message Local adaptation largely segregates between traits affecting light responses and water relations, but population-level differences in stomatal conductance when growth is unconstrained converge among populations under stress. Warming temperatures altered precipitation patterns threaten plant worldwide. European beech ( Fagus sylvatica ) a species that expresses both high phenotypic plasticity local populations. Beech seedlings’ susceptibility to prolonged drought may be...
Abstract Background The permeability of plasma membrane aquaporins (PIPs) to small solutes other than water greatly diversifies their potential functions in plant development and metabolic processes. One such process is stress signalling which hydrogen peroxide (H 2 O ) plays a major role. Based on transport assays carried out yeast, there are differences the degree PIPs Arabidopsis thaliana , permeable H thus they may differentially facilitate transmembrane diffusion. Here, we test whether...
Abstract The roles of different plasma membrane aquaporins (PIPs) in leaf-level gas exchange Arabidopsis thaliana were examined using knockout mutants. Since multiple PIPs are implicated CO2 transport across cell membranes, we focused on identifying the effects mutations photosynthesis, and whether they mediated through control stomatal conductance water vapour (gs), mesophyll (gm), or both. We grew plants low high humidity environments found that contribution to gs was larger under air when...
We report a case where acute varicella infection, chickenpox, mimics the findings of recurrent Hodgkin disease on F-18 FDG PET/CT. A 28-year-old man with history in remission had fatigue, pyrexia, and raised ESR. His PET/CT, performed to exclude lymphoma recurrence, demonstrated FDG-avid lymphadenopathy increased uptake his spleen. day later he developed generalized rash infection. This was managed valacyclovir. Repeat PET/CT done 1 month showed no evidence disease. In this patient...
To determine whether computed tomography can distinguish low risk neck levels that be omitted when dissection is undertaken after chemoradiotherapy.Case series with chart review.Tertiary care center.Head and squamous cell carcinoma patients undergoing chemoradiotherapy between January 1998 June 2008. We compared findings pathology results; used primary location to design selective or superselective dissection; determined these surgeries would have contained all metastatic disease.A total of...
Lipomatous hypertrophy of the interatrial septum (LHIS) may be associated with arrhythmias or sudden death. Increased fluorine-18 fluorodeoxyglucose (FDG) uptake in LHIS is occasionally found on positron emission tomography, and has been attributed to metabolically active brown adipose tissue (BAT) contained within LHIS. We report a case patient suggesting that neither 2 currently known mechanisms glucose by BAT responsible for FDG LHIS, unless mechanism activation exists not previously...
3011 Background: We report results from a pilot study aimed at optimizing the use of CT bi-dimensional measurements (CT-BDM) as prognostic indicator response to IM (Gleevec) in patients with advanced GIST. Methods: 52 enrolled single center multi-center trial evaluating GIST had CTs performed baseline and 1 month (range 21–40 days) after initiation treatment. CT-BDM were using axial plane maximum diameter each lesion its maximal perpendicular dimension. Up 12 lesions evaluated per patient...
We present a case of 53-year-old man with large B-cell non-Hodgkin lymphoma that infiltrated the vermiform appendix. The patient underwent F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT scan) for staging, which demonstrated intense abnormal tracer uptake in After 2 cycles chemotherapy (R-CHOP), follow-up scan complete resolution within This highlights contribution FDG diagnosis and post-therapy evaluation this involvement.
The objective of this study was to determine the impact on image quality and risks in terms artifacts side effects a low-density barium-based suspension as oral contrast material for CT during PET/CT examinations an oncologic patient population.Eighty-five patients (51 men 34 women; mean age, 53 years; age range, 21-87 years) were prospectively randomized receive either 0.1% barium sulfate or no PET/CT. Patients group given 1,350 mL over 60-75 minutes. (18)F-FDG PET component each...
3011
Abstract Roles of three different plasma membrane aquaporins (PIPs) in leaf-level gas exchange Arabidopsis thaliana were examined using single, double and triple knockout mutants compared to the Columbia-0 wild type (WT) plants. Since multiple PIPs are implicated conducting carbon dioxide across membranes, we focused on identifying whether isoforms affect photosynthesis, either mediated through control stomatal conductance water vapour ( g s ) or mesophyll CO 2 m a combination both. In two...
While traditional β-blockers (i.e. competitive orthosteric antagonists of β-adrenergic receptors; βARs) are widely used as cardiovascular therapeutics, adverse effects such fatigue and the nonselective inhibition multiple receptor subtypes often limit maximal effectiveness. An emerging approach to enhance therapeutic targeting is identify allosteric modulators that act cooperatively with ligands. In contrast ligands which bind endogenous ligand binding site, regions topographically distinct...
Abstract Key message A total of 45 aquaporins was identified in Fagus sylvatica , 35 which were differentially expressed spring and summer the leaves, phloem xylem 11-year-old trees. European beech ( ) has been widely studied terms its water relations local adaptation. However, to date, underlying basis conferring adaptation differences availability are unknown. Therefore, we examined expression trees four different provenances representing southern northern range margins, as well core...