A5027821685- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Nuclear Physics and Applications
- Advanced X-ray and CT Imaging
- Radiation Detection and Scintillator Technologies
- Nuclear physics research studies
- Atomic and Subatomic Physics Research
- Nuclear reactor physics and engineering
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Reproductive Health and Contraception
- Cardiac pacing and defibrillation studies
- Lanthanide and Transition Metal Complexes
- Glioma Diagnosis and Treatment
- Fungal Plant Pathogen Control
- Menstrual Health and Disorders
- Amyotrophic Lateral Sclerosis Research
- Ovarian function and disorders
- Blood properties and coagulation
- Fungal Biology and Applications
- Cardiac Arrhythmias and Treatments
- Advanced NMR Techniques and Applications
- Organometallic Complex Synthesis and Catalysis
- Plant Disease Resistance and Genetics
KU Leuven
2016-2025
Stanford University
2021-2023
Universitair Ziekenhuis Leuven
2016-2022
VIB-KU Leuven Center for Brain & Disease Research
2022
Rigshospitalet
2019
TU Dresden
2010-2016
Helmholtz-Zentrum Dresden-Rossendorf
2010-2016
Grünenthal Group (Germany)
1997-2011
Research Center Borstel - Leibniz Lung Center
2000-2008
Heinrich Heine University Düsseldorf
1997-2004
Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds thousands deaths. In search for key targets effective therapeutics, robust animal models mimicking humans are urgently needed. Here, we show that Syrian hamsters, contrast to mice, highly permissive and develop bronchopneumonia strong inflammatory responses the lungs with neutrophil infiltration edema, further confirmed as consolidations visualized by micro-CT alike clinical practice. Moreover, identify an exuberant innate...
The standard uptake value (SUV) approach in oncological positron emission tomography has known shortcomings, all of which affect the reliability SUV as a surrogate targeted quantity, metabolic rate [18F]fluorodeoxyglucose (FDG), K m . Among shortcomings are time dependence, susceptibility to errors scanner and dose calibration, insufficient correlation between systemic distribution volume body weight, and, consequentially, residual inter-study variability arterial input function (AIF)...
To evaluate the feasibility of PET/MRI (positron emission tomography/magnetic resonance imaging) with FDG (18F-fluorodeoxyglucose) for initial staging head and neck cancer. The study group comprised 20 patients (16 men, 4 women) aged between 52 81 years (median 64 years) histologically proven squamous cell carcinoma region. underwent a PET scan on conventional scanner subsequent examination whole-body hybrid system. was administered intravenously prior to (267–395 MBq FDG, 348 average)....
In this article, we introduce, a novel open-source framework designed for efficient parallel computation of projections in tomography leveraging either multiple CPU cores or GPUs. This efficiently implements forward and back projection functions both sinogram listmode data, utilizing Joseph's method, which is further extended to encompass time-of-flight (TOF) PET projections. Our evaluation involves series tests focusing on image reconstruction using data sourced from state-of-the-art...
Introductory paragraph Since the emergence of SARS-CoV-2 causing COVID-19, world is being shaken to its core with numerous hospitalizations and hundreds thousands deaths. In search for key targets effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that productive infection lungs mice limited restricted by early type I interferon responses. contrast, Syrian hamsters highly permissive SARS- CoV-2 develop bronchopneumonia a strong...
During a time with the potential for novel treatment strategies, early detection of disease manifestations at an individual level in presymptomatic carriers hexanucleotide repeat expansion C9orf72 gene (preSxC9) is becoming increasingly relevant.To evaluate changes glucose metabolism before symptom onset amyotrophic lateral sclerosis or frontotemporal dementia preSxC9 using simultaneous fluorine 18-labeled fluorodeoxyglucose ([18F]FDG positron emission tomographic (PET) and magnetic...
Positron emission tomography (PET) plays an increasingly important role in research and clinical applications, catalysed by remarkable technical advances a growing appreciation of the need for reliable, sensitive biomarkers human function health disease. Over last 30 years, large amount physics engineering effort PET has been motivated dominant application during that period, oncology. This led to developments such as PET/CT, whole-body PET, 3D accelerated statistical image reconstruction,...
Evaluation of the quantitative accuracy MR-based attenuation correction (MRAC) in Philips Ingenuity TF whole-body PET/MR. In 13 patients, PET emission data from PET/MR were reconstructed using two different methods for correction. first reconstruction, vendor-provided standard MRAC was used. second a coregistered transmission-based map immediately preceding investigation with stand-alone Siemens ECAT EXACT HR+ scanner used (TRAC). The maps compared regarding occurrence segmentation artifacts...
The electromagnetic dipole strength of the nucleus ${}^{136}$Ba has been investigated. Two measurements were performed with electron energies 7.0 and 11.4 MeV at bremsstrahlung facility ELBE accelerator Helmholtz-Zentrum Dresden-Rossendorf. Photon scattering experiments on same have high-intensity gamma-ray source (HI$\ensuremath{\gamma}$S) Triangle Universities Nuclear Laboratory between 4.7 9.3 MeV. geant4 code used to determine detector response non-nuclear scattered events. Thus it is...
In the last two decades, it has been shown that anatomically-guided PET reconstruction can lead to improved bias-noise characteristics in brain imaging. However, despite promising results simulations and first studies, reconstructions are not yet available for use routine clinical because of several reasons. light this, we investigate whether improvements methods be achieved entirely image domain with a convolutional neural network (CNN). An image-based CNN post-reconstruction approach...
Accurate MR-based attenuation correction (MRAC) is essential for quantitative PET/MR imaging of the brain. In this study, we analyze regional bias caused by MRAC based on Zero-Echo-Time MR images (ZTEAC) compared to CT-based AC (CTAC) static and dynamic PET imaging. addition, results are performance Atlas-based (AtlasAC) implemented in GE SIGNA software version MP24. Methods: Thirty [ 18 F]FDG eleven F]PE2I acquisitions from a were reconstructed using ZTEAC (using research tool, Healthcare),...
The first time-of-flight positron emission tomography (TOF-PET) scanners were developed as early in the 1980s. However, poor light output and low detection efficiency of TOF-capable detectors available at time limited any gain image quality achieved with these TOF-PET over traditional non-TOF PET scanners. discovery LSO other Lu-based scintillators revived interest led to development a second generation high sensitivity spatial resolution mid-2000s. introduction silicon photomultiplier...
Abstract Es wurde ein einfaches Verfahren zur Herstellung der Fluorsulfonsäure ausgearbeitet und verschiedene Eigenschaften dieser Säure bestimmt. Ferner Methyl‐ Äthylester hergestellt untersucht.
Abstract Purpose Next-generation SPECT/CT systems with CdZnTe (CZT) digital detectors in a ring-like setup are emerging to perform quantitative Lu-177 SPECT imaging clinical routine. It is essential assess how the shorter acquisition time might affect image quality and uncertainty on mean absorbed dose of tumors organs at risk compared conventional system. Methods A NEMA Image Quality phantom was scanned 3D CZT system (Veriton, by Spectrum Dynamics) using 6 min per bed position (Symbia T16,...
Die Konstitutionsaufklärung der Strobilurine A und B (4 bzw. 5) wird beschrieben. Es handelt sich um 1-Arylhexatriene, die eine endständige β-Methoxyacrylat-Gruppierung enthalten. Antibiotics from Basidiomycetes, III. Strobilurin and B, Antifungal Metabolites Strobilurus tenacellus The structural elucidation of the strobilurins (4, 5, respectively) is described. These compounds are 1-arylhexatrienes containing a terminal β-methoxyacrylate moiety.
Standard uptake values (SUV) as well tumor-to-blood standard ratios (SUR) measured with [ 18F-]fluorodeoxyglucose (FDG) PET are time dependent. This poses a serious problem for reliable quantification since variability of scan start relative to the injection is persistent issue in clinical oncological Positron emission tomography (PET). In this work, we present method correction of, both, SUR and SUV. Assuming irreversible FDG kinetics, linearly correlated Km (the metabolic rate FDG), where...
The aim of the present study was to evaluate predictive value a novel quantitative measure for spatial heterogeneity FDG uptake, asphericity (ASP) in patients with non-small cell lung cancer (NSCLC).FDG-PET/CT had been performed 60 (15 women, 45 men; median age, 65.5 years) newly diagnosed NSCLC prior therapy. FDG-PET image primary tumor segmented using ROVER 3D segmentation tool based on thresholding at volume-reproducing intensity threshold after subtraction local background. ASP defined...
To evaluate the feasibility of positron emission tomography/magnetic resonance imaging (PET/MR) with (18)fluoro-2-deoxyglucose (FDG) for therapy response evaluation malignant lymphoma.Nine patients lymphoma who underwent FDG-PET/MR before and after chemotherapy were included in this retrospective study. Average time between two scans was 70 days. The evaluated independently by nuclear medicine physicians. Ann Arbor classification used to describe stage. Furthermore, readers also rated PET...
In this article, we evaluate Parallel Level Sets (PLS) and Bowsher's method as segmentation-free anatomical priors for regularized brain positron emission tomography (PET) reconstruction. We derive the proximity operators two PLS use EM-TV algorithm in combination with first order primal-dual by Chambolle Pock to solve non-smooth optimization problem PET reconstruction regularization. addition, compare performance of versions against symmetric asymmetric Bowsher quadratic relative difference...
The electromagnetic dipole strength below the neutron-separation energy has been studied for xenon isotopes with mass numbers A = 124, 128, 132, and 134 in nuclear resonance fluorescence experiments using ELBE bremsstrahlung facility at Helmholtz-Zentrum Dresden-Rossendorf HIgS Triangle Universities Nuclear Laboratory Durham. systematic study gained new information about influence of neutron excess as well deformation on region pygmy resonance. results are compared those obtained chain...