A5073441899- Pancreatic function and diabetes
- Diabetes and associated disorders
- Amyotrophic Lateral Sclerosis Research
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Mosquito-borne diseases and control
- Optical Imaging and Spectroscopy Techniques
- Adenosine and Purinergic Signaling
- Metabolism, Diabetes, and Cancer
- Advanced Fluorescence Microscopy Techniques
- Diabetes Management and Research
- Vector-borne infectious diseases
- Parkinson's Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Cell Image Analysis Techniques
- Diabetes Treatment and Management
- Cannabis and Cannabinoid Research
- Alzheimer's disease research and treatments
- Viral Infections and Vectors
- MRI in cancer diagnosis
- Brain Tumor Detection and Classification
- Biochemical Acid Research Studies
- Lung Cancer Research Studies
- Advancements in Photolithography Techniques
Umeå University
2021-2025
Radboud University Medical Center
2013-2021
Radboud University Nijmegen
2013-2021
KU Leuven
2016-2020
Universitair Ziekenhuis Leuven
2019
Accurate MR-based attenuation correction (MRAC) is essential for quantitative PET/MR imaging of the brain. In this study, we analyze regional bias caused by MRAC based on Zero-Echo-Time MR images (ZTEAC) compared to CT-based AC (CTAC) static and dynamic PET imaging. addition, results are performance Atlas-based (AtlasAC) implemented in GE SIGNA software version MP24. Methods: Thirty [ 18 F]FDG eleven F]PE2I acquisitions from a were reconstructed using ZTEAC (using research tool, Healthcare),...
Viral tropism within the brain and role(s) of vertebrate immune response to neurotropic flaviviruses infection is largely understudied. We combine multimodal imaging (cm-nm scale) with single nuclei RNA-sequencing study Langat virus in wildtype interferon alpha/beta receptor knockout (Ifnar
Time-of-flight (TOF) PET data provide an effective means for attenuation correction (AC) when no (or incomplete or inaccurate) information is available. Since MR scanners little on photon of different tissue types, AC in hybrid PET/MR has always been challenging. In this contribution, we aim at validating the activity reconstructions maximum-likelihood ordered-subsets and (OSAA) reconstruction algorithm a patient brain set. We present quantitative comparison joint with current clinical gold...
Objective: 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) single-center studies using support vector machine (SVM) approach to differentiate amyotrophic lateral sclerosis (ALS) from controls have shown high overall accuracy on an individual patient basis local a priori defined classifiers. The aim of the study was validate SVM multicentric level.Methods: A previously Belgian (BE) group 175 ALS patients (61.9 ± 12.2 years, 120M/55F) and 20 screened healthy (62.4 6.4...
Noninvasive beta cell mass (BCM) quantification is a crucial tool to understand diabetes development and progression. [(111)In]exendin promising agent for in vivo imaging, but tracer testing has been hampered by the lack of well-defined rodent models.Biodistribution pancreatic uptake were compared rats mice. In selected models, amount accumulation pancreas other organs was determined using model alloxan-induced loss. GLP-1R expression levels analyzed RT-PCR immunohistochemistry.Namely Brown...
Abstract Pancreatic islet transplantation is a promising therapy for patients with type 1 diabetes. However, the duration of long-term graft survival limited due to inflammatory as well non-inflammatory processes and routine clinical tests are not suitable monitor survival. 111 In-exendin-SPECT (single photon emission computed tomography) method non-invasively image islets after has potential help improve outcome. Whether allows detecting small differences in beta-cell mass (BCM) measuring...
Introduction Optical Projection Tomography (OPT) and light sheet fluorescence microscopy (LSFM) are high resolution optical imaging techniques, ideally suited for ex vivo 3D whole mouse brain imaging. Although they exhibit specificity their targets, the anatomical detail provided by tissue autofluorescence remains limited. Methods T1-weighted images were acquired from 19 BABB or DBE cleared brains to create an MR template using serial longitudinal registration. Afterwards, fluorescent OPT...
Islet transplantation is a promising treatment for type 1 diabetic patients. However, there acute as well chronic loss of islets after transplantation. A noninvasive imaging method that could monitor islet mass might help to improve outcomes. In this study, were visualized in rat model with dedicated small-animal SPECT scanner by targeting the glucagonlike peptide-1 receptor (GLP-1R), specifically expressed on β-cells, <sup>111</sup>In-labeled exendin-3. <b>Methods:</b> Targeting...
Abstract Tick-borne encephalitis virus (TBEV) is a neurotropic flavivirus that causes thousands of human infections annually. Viral tropism in the brain determined by presence necessary receptors, entry factors and ability to overcome host defenses. The viral structural proteins, pre-membrane (prM) envelope (E), play an important role receptor binding, membrane fusion, particle maturation, antibody neutralization. To understand how these proteins influence distribution brain, we generated...
Pancreatic islet transplantation can be a more permanent treatment for type 1 diabetes compared to daily insulin administration. Quantitative and longitudinal noninvasive imaging of viable transplanted islets might help further improve this novel therapy. Since express dopamine 2 (D2) receptors, they could visualized by targeting receptor. Therefore, the D2 receptor antagonist based tracer [(125/123)I][IBZM] was selected visualize in rat model. BZM radioiodinated, labeling optimized position...
Somatostatin receptor targeting is considered the standard nuclear medicine technique for visualization of neuroendocrine tumors (NET). Since not all NETs over-express somatostatin receptors, search novel targets, visualizing these NETs, ongoing. Many expressing low levels, express glucose-dependent insulinotropic polypeptide (GIP) receptors (GIPR). Here, we evaluated performance [Lys37(DTPA)]N-acetyl-GIP1-42, a newly synthesized GIP analogue to investigate whether NET imaging via GIPR...
BACKGROUND: Recently, four neuropathological stages of amyotrophic lateral sclerosis (ALS) with spreading transactive response DNA-binding protein-43 pathology were described. Although 18F-FDG PET has been useful in diagnosis and prognosis ALS patients, in-vivo disease staging using glucose metabolic patterns across the different not attempted so far. In this study, we investigated whether discriminant brain regions stage model can be translated to for ALS. Furthermore, examined correlation...
A non‐invasive imaging method to monitor islet grafts could provide novel and improved insight into the fate of transplanted islets and, potentially, effect therapeutic interventions. Therefore, such an help improve long‐term transplantation outcome. Here, we investigated use [ 123 I ] IBZM for insulin positive graft volume quantification longitudinal monitoring. SPECT images were acquired 6 weeks after in calf muscle rats. For analysis, rats monitored by 10 weeks. After animals euthanized,...
Abstract Optical projection tomography (OPT) and light sheet fluorescence microscopy (LSFM) are high-resolution optical imaging techniques operating in the mm-cm range, ideally suited for ex vivo 3D whole mouse brain imaging. Although these exhibit high sensitivity specificity antibody-labeled targets, provided anatomical information remains limited. To allow mapping of fluorescent signal brain, we developed a novel magnetic resonance (MR) – based template with its associated tissue priors...
Abstract Viral tropism within the brain and role(s) of vertebrate immune response to neurotropic flaviviruses infection is largely understudied. We combined multimodal imaging (cm-nm scale) with single nuclei RNA- sequencing study Langat virus in wildtype interferon alpha/beta receptor knockout ( Ifnar −/− ) mice visualize viral pathogenesis define molecular mechanisms. Whole was imaged by Optical Projection Tomography coregistered ex vivo MRI. Infection limited grey matter sensory systems...