A5032496940- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Psychedelics and Drug Studies
- Forensic Toxicology and Drug Analysis
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Prenatal Substance Exposure Effects
- Biochemical Analysis and Sensing Techniques
- Sleep and related disorders
- Neurogenesis and neuroplasticity mechanisms
- Attention Deficit Hyperactivity Disorder
- Nerve injury and regeneration
- Treatment of Major Depression
- Zebrafish Biomedical Research Applications
- Anesthesia and Neurotoxicity Research
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
UNSW Sydney
2015-2025
Macquarie University
2012-2015
Centre National de la Recherche Scientifique
2008-2010
Université de Bordeaux
2009-2010
The University of Sydney
2003-2007
Abstract Paraventricular thalamus (PvTh) is uniquely placed to contribute reinstatement of drug and reward seeking. It projects extensively regions implicated in including accumbens shell (AcbSh), prefrontal cortex (PFC) basolateral amygdala (BLA), receives afferents from other important for such as lateral hypothalamus. We used complementary neuroanatomical functional approaches study the role PvTh context‐induced (renewal) extinguished reward‐seeking. Rats were trained respond a context A,...
Several minor tobacco alkaloids have been found to exhibit properties pharmacologically relevant the addictive profile of tobacco; however, little is known their effects on a behavioural model drug addiction. In this study we compared locomotor and reinforcing intravenous nicotine (30 µg/kg per infusion) vs. cocktail plus five in smoke (anabasine, nornicotine, anatabine, cotinine myosmine). Rats were initially tested for response or with six injections over 1 h. We then assessed spontaneous...
Mephedrone (MMC) is a relatively new recreational drug that has rapidly increased in popularity recent years. This study explored the characteristics of intravenous MMC self-administration rat, with methamphetamine (METH) used as comparator drug. Male Sprague-Dawley rats were trained to nose poke for or METH daily 2 h sessions over 10 d acquisition period. Dose-response functions then established under fixed- and progressive-ratio (FR PR) schedules three subsequent weeks testing. Brains...
Humans and animals use information about future access to rewards influence their behaviour in the present, however evidence for this is largely anecdotal. Here we nicotine intravenous self-administration paradigm ask whether rats can an auditory stimulus signalling a long (450 s) signalled time-out on next trial intake present. Rats were trained choose between low (15 µg/kg/infusion), medium (30 µg/kg/infusion) or high (60 doses of any given trial. Trials either had 'light' with no tone...
Delivery across the blood‐brain barrier (BBB) is one of most challenging tasks for modern biopharmaceutics. Many attempts have been taken, with only low delivery efficacies achieved so far. We report a new transferrin receptor‐targeting (TfR) RNA aptamer conjugated to DSPE lipid that leads an unprecedented effective uptake in brain, brain‐to‐serum ratios up 6.5 mice. This result superior recently published values < 1 antibody conjugates and nanovesicles, pointing successful combined...
Delivery across the blood‐brain barrier (BBB) is one of most challenging tasks for modern biopharmaceutics. Many attempts have been taken, with only low delivery efficacies achieved so far. We report a new transferrin receptor‐targeting (TfR) RNA aptamer conjugated to DSPE lipid that leads an unprecedented effective uptake in brain, brain‐to‐serum ratios up 6.5 mice. This result superior recently published values < 1 antibody conjugates and nanovesicles, pointing successful combined...
Drug use may be exacerbated in environments which lack alternative means of engaging rewarding behaviour. When rewards are available, drug decrease-an effect that can harnessed for therapeutic benefit. This idea is particularly well-supported by recent preclinical evidence demonstrating a majority rats will readily choose potent non-drug reward over cocaine or heroin. Here we examine whether the same holds true nicotine, considered to have one highest addiction liabilities amongst drugs...
Chromatin remodelling is integral to the formation of long-term memories. Recent evidence suggests that histone modification may play a role in persistence memories associated with drug use. The present series experiments aimed examine effect deacetylase (HDAC) inhibition on extinction and reinstatement nicotine self-administration. Rats were trained intravenously self-administer for 12 days fixed-ratio 1 schedule. In Experiment 1, responding was then extinguished through removal...