A5002291789- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Atomic and Subatomic Physics Research
- Particle physics theoretical and experimental studies
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Medical and Health Sciences Research
- High-Energy Particle Collisions Research
- Radiation Dose and Imaging
- Corporate Governance and Management
- Radiomics and Machine Learning in Medical Imaging
- Nuclear physics research studies
- Cold Atom Physics and Bose-Einstein Condensates
- Advanced MRI Techniques and Applications
- CCD and CMOS Imaging Sensors
- Quantum many-body systems
- Glioma Diagnosis and Treatment
- Medical Practices and Rehabilitation
- Radiation Therapy and Dosimetry
- Health and Medical Studies
- Radioactive Decay and Measurement Techniques
Universität Innsbruck
2022-2024
Austrian Academy of Sciences
2022-2024
Heidelberg University
2020-2023
Heidelberg Institute for Theoretical Studies
2020-2023
University of Maryland, College Park
2022
Joint Quantum Institute
2022
Toronto Metropolitan University
2013-2021
Innovation, Science and Economic Development Canada
2021
Royal Marsden NHS Foundation Trust
2001-2014
Institute of Cancer Research
2001-2014
Gauge theories form the foundation of modern physics, with applications ranging from elementary particle physics and early-universe cosmology to condensed matter systems. We perform quantum simulations unitary dynamics a U(1) symmetric gauge field theory demonstrate emergent irreversible behavior. The highly constrained are encoded in one-dimensional Bose-Hubbard simulator, which couples fermionic fields through dynamical fields. investigated global quenches equilibration steady state well...
To investigate and measure the metabolism of colorectal cancer liver metastases using 18F-fluorodeoxyglucose positron emission tomography (FDG PET), before during first month chemotherapy. The findings were compared with tumor outcome conventionally assessed changes in size.Patients treated fluorouracil (5FU) as a protracted venous infusion (300 mg/m2/d), or without interferon-alpha 2b for two 10-week blocks separated by 2-week break. Before at 1 to 2 4 5 weeks on treatment, FDG PET scans...
Using dual theories embedded into a larger unphysical Hilbert space along entanglement cuts, we study the structure of Z_{2} lattice gauge theory in (2+1) spacetime dimensions. We demonstrate Li and Haldane's conjecture, show consistency Hamiltonian with Bisognano-Wichmann theorem. Studying nonequilibrium dynamics after quench, provide an extensive description thermalization which proceeds characteristic sequence: Maximization Schmidt rank spreading level repulsion at early times,...
A fast accurate iterative reconstruction (FAIR) method suitable for low-statistics positron volume imaging has been developed. The method, based on the expectation maximization-maximum likelihood (EM-ML) technique, operates list-mode data rather than histogrammed projection and can, in just one pass through data, generate images with same characteristics as several ML iterations. Use of preserves maximum sampling accuracy implicitly ignores lines response (LORs) which no counts were...
Carcinoma of the pancreas is an aggressive tumour with extremely poor prognosis. Recent studies have shown that chemotherapy can improve survival as well quality life. Since prognosis generally poor, identification early responders to important avoid unnecessary toxicity in patients who are not responding. Response assessment by conventional radiographic methods problematical because treatment induces fibrosis and makes measurements difficult. The aim this pilot study was assess...
This study documents the optical reflectance characteristics of pigmented skin lesions and evaluates their potential for improving differential diagnosis malignant melanoma from benign lesions.
We propose a scalable analog quantum simulator for electrodynamics in two spatial dimensions. The setup the U(1) lattice gauge field theory employs interspecies spin-changing collisions an ultracold atomic mixture trapped optical lattice. engineer plaquette terms magnetic fields, thus solving major obstacle toward experimental realizations of realistic theories higher apply our approach to pure compact QED and discuss how phenomenon confinement electric charges can be described by simulator.
Abstract Patients designated to receive 131I-meta-iodobenzylguanadine (mIBG) for the treatment of neural crest tumours have been scanned with 124I-mIBG using MUP-PET positron camera. Uptake was detected in tumour sites lung, liver and abdomen. The tomographic images produced allowed estimates be made concentration mlBG both normal tissue. From these data it is possible predict radiation doses that would achieved therapy levels (up 11 GBq) 131I-mIBG. uptake are between 0.5 2.0 kBq/g...
A dual radionuclide subtraction technique for external detection of tumours has been evaluated to determine the viability method use with radioisotope labelled antibodies. number scintigraphic investigations have carried out 131I-labelled antibodies carcinoembryonic antigen (CEA). The were performed on patients metastatic disease known produce CEA. was used account blood and tissue background. found localise in lesions, but using 99Tcm-labelled HSA pertechnetate gave ambiguous results, which...
The limitations of traditional targeted radionuclide therapy (TRT) dosimetry can be overcome by using voxel-based techniques. All techniques are reliant on a sequence quantitative emission and transmission data. use (131)I, for example, with NaI or mIBG, presents additional quantification challenges beyond those encountered in low-energy NM diagnostic imaging, including dead-time correction photon scatter penetration the camera head. Royal Marsden Dosimetry Package (RMDP) offers complete...
The Rutherford Appleton Laboratory clinical positron camera consists of two opposed multiwire proportional chambers (MWPCs) mounted on a rotating gantry capable performing routine nuclear medicine studies. system has operated since the end 1986 with complete reliability. It sensitivity 37 kcps MBq-1 cm3 per axial cm for 20 diameter uniformly filled cylinder activity. best spatial resolution obtainable is about 6 mm, although in practice images are smoothed order to reduce statistical noise...
Several techniques for performing digital image restoration are reviewed and the problems associated with evaluating processing discussed. An application of constrained deconvulution to images liver produced by single-photon emission computed tomography is presented. Specific evaluation criteria suggested based on these, choice conditions best suited proposed. Typically cold tumor contrast can be improved a factor greater than 2 whilst mottle increases negligibly.
Measurements of the functioning volume thyroid tissue have been made in 22 patients undergoing radioiodine therapy for thyrotoxicosis, using a prototype multiwire proportional counter positron camera. Tomographic images were produced distribution 124I thyroid. Functioning volumes found to be range 21-79 cm3 with errors order +/- 4% 14%. Radioiodine uptake varied from 28% 98%. Using value 6 days effective half-life hyperactive thyroids, radiation doses standard administration 75 MBq 131I 11...
Four reconstruction techniques for positron volume imaging have been evaluated scanners based on rotating planar detectors using measured and simulated data. The four compared are backproject then filter (BPF), the 3D reprojection (3D RP) method filtered backprojection (FBP), Fourier rebinning (FORE) in conjunction with 2D FBP (FORE+2D FBP) ordered subsets expectation maximization OSEM). comparison was image resolution trade-off between contrast noise. In general FORE+2D offered a better...
Successful treatment of skin cancer, especially melanoma, depends on early detection, but diagnostic accuracy, even by experts, can be as low 56% so there is an urgent need for a simple, accurate, non-invasive tool.