A5005185910- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Radioactive Decay and Measurement Techniques
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Nuclear Physics and Applications
- Image and Signal Denoising Methods
- Target Tracking and Data Fusion in Sensor Networks
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Radioactive contamination and transfer
- Nuclear reactor physics and engineering
- Cancer Treatment and Pharmacology
- X-ray Spectroscopy and Fluorescence Analysis
- Electron and X-Ray Spectroscopy Techniques
- Radioactivity and Radon Measurements
- Advanced MRI Techniques and Applications
Inserm
2017-2022
Université Toulouse III - Paul Sabatier
2017-2022
Universidad de Costa Rica
2017-2022
Centre de Recherche en Cancérologie de Toulouse
2017-2021
Radiopharmaceutical dosimetry depends on the localization in space and time of radioactive sources requires estimation amount energy emitted by deposited within targets. In particular, when computing resources are not accessible, this task can be performed using precomputed tables specific absorbed fractions (SAFs) or S values based dosimetric models. The aim OpenDose collaboration is to generate make freely available a range data tools. <b>Methods:</b> brings together expertise from 18...
This study's aim was to develop our dosimetric methodology using a commercial workstation for the routine evaluation of organs at risk during peptide receptor radionuclide therapy (PRRT) with 177Lu.First, planar and SPECT sensitivity factors were determined on phantoms. The reconstruction parameters optimized by SPECT/CT image acquisition NEMA IEC phantom containing 500 ml bottle 177Lu, simulate kidney. recovery coefficients various For red marrow, this calculated that contained centrally...
Purpose The aim of this study was to quantitatively compare five commercial dosimetric software platforms based on the analysis clinical datasets patients who benefited from peptide receptor radionuclide therapy (PRRT) with 177 Lu‐DOTATATE (LUTATHERA ® ). Methods performed two during cycles PRRT Lu. Single photon emission computed tomography/computed tomography images were acquired at 4, 24, 72, and 192 h post injection. Reconstructed generated using Dosimetry Toolkit (DTK) Xeleris™...
Abstract Background The aim of this study was to compare a commercial dosimetry workstation (PLANET® Dose) and the approach (GE Dosimetry Toolkit® OLINDA/EXM® V1.0) currently used in our department for quantification absorbed dose (AD) organs at risk after peptide receptor radionuclide therapy with [ 177 Lu]Lu-DOTA-TATE. Methods An evaluation on phantom performed determine SPECT calibration factor variations over time Time Integrated Activity Coefficients (TIACs) obtained two approaches....
Differentiated thyroid cancer has been treated with radioiodine for almost 80 years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresolved. Multi-centre clinical studies are required to ensure recruitment sufficient patients achieve statistical significance address these issues. Optimisation standardisation data acquisition processing necessary quantitative imaging patient-specific dosimetry. A European network centres...
Monte Carlo modelling of SPECT imaging in Molecular Radiotherapy can improve activity quantification. Until now, with GATE only considered circular orbit (CO) acquisitions. This cannot reproduce auto-contour acquisitions, where the detector head moves close to patient image resolution. The aim this work is develop and validate an auto-contouring step-and-shoot acquisition mode for modelling.177Lu 131I experimental acquisitions performed on a Siemens Symbia T2 GE Discovery 670 gamma camera,...
Purpose Small‐scale dosimetry studies generally consider an artificial environment where the tumors are spherical and radionuclides homogeneously biodistributed. However, tumor shapes irregular radiopharmaceutical biodistributions heterogeneous, impacting energy deposition in targeted radionuclide therapy. To bring realism, we developed a dosimetric methodology based on three‐dimensional vitro model of follicular lymphoma incubated with rituximab, anti‐CD20 monoclonal antibody used treatment...
The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesised by our group. fluorescent dye has been reported as marker of astroglia in the neocortex rodents vivo.The aim this study to perform toxicological evaluation [18F]SRF101 and estimate human radiation dosimetry based on preclinical studies.Radiation studies were conducted biokinetic data obtained from mouse model. A single-dose toxicity carried out. limit chosen <100 μg,...
Internal dosimetry intercomparisons are essential for the verification of applied models and consistency results'. To that aim, First Regional Intercomparison was organised in 2005, results led to Second Exercise 2013, which frame RLA 9/066 coordinated by Autoridad Regulatoria Nuclear Argentina. Four simulated cases covering intakes 131I, 137Cs Tritium were proposed. Ninteen centres from thirteen different countries participated this exercise. This paper analyses participants' second...
aInstitute of Nuclear Medicine, UCL, UK bQueen Elizabeth Hospital, Adelaide, Australia Abstracts the 34th Annual Meeting British Medicine Society Manchester International Conference Centre, UK, 27–29 March 2006
Abstract Background: The aim of this study was to compare a commercial dosimetry workstation (PLANET®Dose) and the approach (GE Dosimetry Toolkit® OLINDA/EXM® V1.0) currently used in our department for quantification absorbed dose (AD) organs at risk after peptide receptor radionuclide therapy with [ 177 Lu]Lu-DOTA-TATE. Methods: An evaluation on phantom performed determine SPECT calibration factor variations over time Time Integrated Activity Coefficients (TIACs) obtained two approaches....
Abstract Background: The aim of this study was to compare a commercial dosimetry workstation (PLANET®Dose) and the approach (GE Dosimetry Toolkit® OLINDA/EXM® V1.0) currently used in our department for quantification absorbed dose (AD) organs at risk after peptide receptor radionuclide therapy with [ 177 Lu]Lu-DOTA-TATE. Methods: An evaluation on phantom performed determine SPECT calibration factor variations over time Time Integrated Activity Coefficients (TIACs) obtained two approaches....
Abstract Background: Recently, commercial software tools have become available for dosimetry evaluations in clinical settings. The aim of this study was to compare a workstation (PLANETâDose) and the approach (GE Dosimetry Toolkit® OLINDA/EXM® V1.0) currently used our department quantification absorbed dose organs at risk after peptide receptor radionuclide therapy with 177 Lu-DOTATATE. Methods: First, an evaluation on phantom, data acquisition 5 time points, performed determine SPECT...
Abstract Background: The aim of this study was to compare a commercial dosimetry workstation (PLANET®Dose) and the approach (GE Dosimetry Toolkit® OLINDA/EXM® V1.0) currently used in our department for quantification absorbed dose organs at risk after peptide receptor radionuclide therapy with [177Lu]Lu-DOTA-TATE. Methods: An evaluation on phantom performed determine SPECT calibration factor variations over time Time Integrated Activity Coefficients (TIACs) doses obtained two tools. Then,...