A5018079265- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Radiopharmaceutical Chemistry and Applications
- Thyroid and Parathyroid Surgery
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Disorders and Treatments
- Head and Neck Anomalies
- Neuroendocrine Tumor Research Advances
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Nonmelanoma Skin Cancer Studies
- Ear and Head Tumors
- Advanced X-ray and CT Imaging
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Cutaneous Melanoma Detection and Management
- Sexual Differentiation and Disorders
Institut Claudius Regaud
2015-2024
Institut universitaire du cancer de Toulouse Oncopole
2015-2024
Centre Hospitalier Universitaire de Toulouse
2014-2023
Clinical Trial Investigators
2023
Institut Gustave Roussy
2023
Centre Hospitalier Régional et Universitaire de Nancy
2023
European Association of Nuclear Medicine
2019-2020
Sorbonne Université
2018
Peking Union Medical College Hospital
2016
Centre de Médecine Préventive
2016
It is not clear whether the administration of radioiodine provides any benefit to patients with low-risk thyroid cancer after a complete surgical resection. The smallest possible amount would improve care.
In patients with low-risk differentiated thyroid cancer undergoing thyroidectomy, the postoperative administration of radioiodine (iodine-131) is controversial in absence demonstrated benefits.In this prospective, randomized, phase 3 trial, we assigned who were thyroidectomy to receive ablation (1.1 GBq) after injections recombinant human thyrotropin (radioiodine group) or no (no-radioiodine group). The primary objective was assess whether therapy noninferior respect a composite end point...
Abstract Purpose: To evaluate the efficacy and safety of dabrafenib-trametinib-131I for treatment radioactive iodine refractory metastatic differentiated thyroid cancer (DTC) with a BRAF p.V600E mutation. Patients Methods: A prospective phase II trial including patients RECIST progression within 18 months no lesion > 3 cm. Following baseline recombinant human (rh)TSH-stimulated diagnostic whole-body scan (dc1-WBS), dabrafenib trametinib were given 42 days. second rhTSH-stimulated dc...
Purpose In the ESTIMABL phase III trial, thyroid ablation rate was equivalent for two thyroid-stimulating hormone (TSH) stimulation methods (thyroid withdrawal [THW] and recombinant human TSH [rhTSH]) iodine-131 ( 131 I) activities (1.1 or 3.7 GBq). The objectives of this article were to present health-related quality-of-life (HRQoL) results a cost-effectiveness evaluation performed alongside trial. Patients Methods HRQoL utility longitudinally assessed, from random assignment follow-up...
Abstract Background: Two-thirds of patients with metastatic differentiated thyroid cancer (DTC) become refractory to radioactive iodine (RAIR). The inhibition the MAP-kinase pathway that is activated in case BRAFV600E mutation might increase RAI incorporation into foci and reverse refractoriness. MERAIODE a prospective multicentric open-label phase II trial, using one-stage Fleming design, evaluating efficacy tolerance trametinib (a MEK inhibitor) dabrafenib BRAF treatment followed by...
Background: Anaplastic thyroid carcinoma (ATC) is a rare and frequently fatal type of cancer. The degree heterogeneity in survival rates for ATC incompletely studied. This study evaluated the factors associated with overall (OS) patients using multicenter real-world data from national tertiary care center network France. Methods: In this multicenter, retrospective cohort study, all diagnosed between 2010 2020 were identified database French ENDOCAN-TUTHYREF network. Factors OS examined...
Abstract Objective To evaluate feasibility, SLN detection rate, and location of lymphoscintigraphy in sentinel lymph node (SLN) biopsy for early cervical cancer. Methods Ancillary analysis data from the multicenter prospective SENTICOL study (January 2005–June 2007) patients with cancer (FIGO stage IA emboli to IB1) was conducted. Preoperative performed after intracervical administration 60 or 120 MBq 99m Tc-labeled radiocolloid on day before (long protocol) morning (short surgery. SLNs were...
Journal Article Fluorodeoxyglucose positron emission tomography fails to detect distant metastases at initial staging of melanoma patients with metastatic involvement sentinel lymph node Get access T. Wagner, Wagner Nuclear Medicine Department, Toulouse Purpan University Hospital, Place du Dr Baylac, TSA 40031, cedex 31059, France Thomas Wagner. E‐mail: thomwagner@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar N. Meyer, Meyer Paul‐Sabatier and...
Differentiated thyroid cancer has been treated with radioiodine for almost 80 years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresolved. Multi-centre clinical studies are required to ensure recruitment sufficient patients achieve statistical significance address these issues. Optimisation standardisation data acquisition processing necessary quantitative imaging patient-specific dosimetry. A European network centres...
Radioiodine (I-131) therapy is of proven efficacy for differentiated thyroid carcinoma. However, its relies on specific uptake mechanisms, which may be lost during the evolution disease. Attempts to increase iodine such tumors have been made using retinoic acid because it exerts redifferentiating effects thyrocytes. This study aims assess capability (RA) treatment reinforce 131-irradiation metastatic and progressive multi-irradiated cancer. In this clinical prospective study, 11 patients...
This study assesses the accuracy of prospective phase-gated PET/CT data binning and presents a retrospective method that improves image quality consistency. Respiratory signals from 17 patients who underwent 4D were analysed to evaluate reproducibility temporal triggers used for standard phase-based gating method. Breathing reprocessed implement PET binning. The mean deviation time lags between automatic provided by Real-time Position Management (RPM, Varian) device inhalation peaks derived...
A 58-old-man underwent <sup>18</sup>F-fluorocholine PET/CT for restaging of prostate cancer because a rising level prostate-specific antigen.<sup>18</sup>F-fluorocholine showed no significant tracer uptake at the site prostatectomy or pelvic lymph nodes. Incidental high was observed in 26 × 23 mm left thyroid nodule. benign tumor (oncocytic adenoma thyroid) diagnosed after loboisthmectomy.
Radioiodine is a therapeutic option in Europe for Graves' disease (GD) and toxic multinodular goiter (MNG).To compare empiric calculated I activities using 2013 EANM recommendations. To look predictive factors of response to an activity I. assess clinical situations favoring treatment modalities.Prospective monocentric study outcomes at 1 year follow-up 86 patients with GD MNG who received (348-939 MBq). Differences between were confronted outcomes. Physicians not aware the time...
The aim of this study was to evaluate the impact using Bayesian penalized likelihood (BPL) algorithm on a bismuth germanium oxide positron emission tomography (PET)/computed (CT) system for F-FDG PET/CT exams in case low injected activity and scan duration.F-FDG respiratory gated performed 102 cancer patients, with ∼2 MBq/kg F-FDG, were reconstructed two algorithms: ordered subset expectation maximization (OSEM) BPL. signal-to-noise ratio (SNR) calculated as mean standard uptake value (SUV)...
Abstract Background Prophylactic central neck dissection in clinically low-risk cT1bT2N0 papillary thyroid carcinoma is controversial, due to a large number of conflicting retrospective studies, some showing an advantage terms locoregional recurrence, others no advantage. These previous studies all show high rates excellent response. We aim demonstrate the non-inferiority thyroidectomy alone as compared total with prophylactic conjunction adjuvant RAI 30 mCi rTSH stimulation response at 1...