A5029132645- Statistical Methods in Clinical Trials
- Pharmaceutical Practices and Patient Outcomes
- Renal Transplantation Outcomes and Treatments
- Patient Safety and Medication Errors
- Medication Adherence and Compliance
- Statistical Methods and Inference
- Body Composition Measurement Techniques
- Electronic Health Records Systems
- Organ Transplantation Techniques and Outcomes
- Advanced Causal Inference Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Cervical Cancer and HPV Research
- Respiratory and Cough-Related Research
- Endometrial and Cervical Cancer Treatments
- Asthma and respiratory diseases
- Dermatological and Skeletal Disorders
- Parathyroid Disorders and Treatments
- Breast Cancer Treatment Studies
- Artificial Intelligence in Healthcare
- HIV/AIDS drug development and treatment
- Pharmacological Effects and Toxicity Studies
- Machine Learning in Healthcare
- Hemodynamic Monitoring and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Electrical and Bioimpedance Tomography
Institut Génétique Nantes Atlantique
2022
Inserm
2009-2020
Nantes Université
2015-2020
Université de Tours
2017-2020
Sciences, Philosophie, Histoire
2014-2020
Institut de Transplantation Urologie en Nephrologie
2015-2018
University College London
2016-2018
Centre Hospitalier Universitaire de Nantes
2015-2017
Universidad de Londres
2016
Medical University of Vienna
2016
Purpose Sentinel lymph node (SLN) biopsy may be used to target metastases in patients with early cervical cancer. Whether SLN only is acceptable the staging and surgical management of cancer remains unknown. This prospective multicenter study (SENTICOL [Ganglion Sentinelle dans le Cancer du Col]) assessed sensitivity negative predictive value (NPV) biopsy. Patients Methods Adults carcinoma who met International Federation Gynecology Obstetrics criteria for stage IA1 lymphovascular space...
Summary Chronic thromboembolic pulmonary hypertension (CTEPH) has been estimated to occur in 0.1–0.5% of patients who survive a embolism (PE), but more recent prospective studies suggest that its incidence may be much higher. The absence initial haemodynamic evaluation at the time PE should explain this discrepancy. We performed multicentre study including with order assess prevalence and describe risk factors CTEPH. Follow-up every year included an dyspnea echocardiography using predefined...
J Clin Hypertens (Greenwich) . 2012; 14:429–434. © 2012 Wiley Periodicals, Inc. The aim of this study was to validate a French translation the structured self‐report 8‐item Morisky Medication Adherence Scale (MMAS‐8) and determine its psychometric properties in patients taking antihypertensive medication. An observational cross‐sectional conducted hypertensive unit university hospital. MMAS‐8 translated according international guidelines. Internal consistency assessed using Cronbach α...
Abstract Background Medication errors can occur at any of the three steps medication use process: prescribing, dispensing and administration. We aimed to determine incidence, type clinical importance drug administration identify risk factors. Methods Prospective study based on disguised observation technique in four wards a teaching hospital Paris, France (800 beds). A pharmacist accompanied nurses witnessed preparation drugs all patients during rounds each six days per ward. Main outcomes...
Abstract Controlling for confounding bias is crucial in causal inference. Distinct methods are currently employed to mitigate the effects of bias. Each requires introduction a set covariates, which remains difficult choose, especially regarding different methods. We conduct simulation study compare relative performance results obtained by using four sets covariates (those causing outcome, those treatment allocation, both outcome and all covariates) methods: g-computation, inverse probability...
Critical illness affects body composition profoundly, especially cell mass (BCM). BCM loss reflects lean tissue wasting and could be a nutritional marker in critically ill patients. However, assessment with usual isotopic or tracer methods is impractical intensive care units (ICUs). We aimed to modelize the of patients using variables available at bedside. Fat-free (FFM), bone mineral (Mo), extracellular water (ECW) 49 were measured prospectively by dual-energy X-ray absorptiometry...
In this study, we assessed the change in skin microbiota composition, relative abundance, and diversity with physiology disruption induced by SLS patch. Healthy women declaring to have a reactive were submitted 0.5% aqueous sodium lauryl sulfate solution application under occlusive patch condition for 24 h. Skin properties characterized tewametry, corneometry, colorimetry bacterial was 16S rRNA sequencing. Analysis before one day after removal revealed an increase of redness decrease stratum...
Laboratory testing is frequently unnecessary, particularly repetitive testing. Among the interventions proposed to reduce unnecessary testing, Computerized Decision Support Systems (CDSS) have been shown be effective, but their impact depends on technical characteristics. The objective of study was evaluate a Serology-CDSS providing point care reminders previous existing serology results, embedded in Physician Order Entry at university teaching hospital Paris, France.A CDSS implemented...
Objective To examine the impact of oncologist awareness palliative care (PC), intervention PC team (PCT) and multidisciplinary decision-making on three quality indicators end-of-life (EOL) care. Setting Cochin Academic Hospital, Paris, 2007–2008. Design participants A 521 decedent case series study nested in a cohort 735 metastatic cancer patients previously treated with chemotherapy. Indicators were location death, number emergency room (ER) visits last month life chemotherapy...
Estimation of body composition as fat-free mass (FFM) is subjected to many variations caused by injury and stress conditions in the intensive care unit (ICU). Body cell (BCM), metabolically active part FFM, reported be more specifically correlated changes nutritional status. Bedside estimation BCM could help provide valuable markers status may promote understanding metabolic consequences energy deficit ICU patients. We aimed quantify BCM, water compartments FFM methods usable at bedside for...
Repeated outbreaks of vancomycin-resistant Enterococcus faecium (VRE) occurred between 2004 and 2010 in Assistance Publique--Hôpitaux de Paris (AP-HP), a 23,000-bed multi-hospital institution. From August to December 2005, the French guidelines for preventing cross-transmission multiresistant bacteria were applied. Because number VRE cases continued increase, an institutional control programme was implemented from January 2006 onwards: it foresees stopping transfer contact patients,...
Drug prescribing errors are frequent in the hospital setting and pharmacists play an important role detection of these errors. The objectives this study (1) to describe drug rate during patient's stay, (2) find which characteristics for a error most predictive their reproduction next day despite pharmacist's alert (i.e. override alert). We prospectively collected all medication order lines 18 days 7 medical wards' using computerized physician entry. described modelled according chronology...
Chemotherapy remains the gold standard for advanced cancer. Pemetrexed, a chemotherapeutic agent used in non-small cell lung cancer, can induce significant side effects patients. Although microbiota's role efficacy and/or toxicity of chemotherapy agents has been demonstrated, impacts pemetrexed on gut microbiota and gastrointestinal inflammation remain unknown. The objective this study was to evaluate impact tumor graft composition immunodeficient mice. faecal studied with metabarcoding...
Combination antiretroviral therapy (cART) can cause potentially stigmatizing facial lipoatrophy. Encouraging preliminary results have been reported with 2.5% polyacrylamide hydrogel for reconstruction. The aim of this multicenter, open-label noncomparative pilot study was to evaluate the efficacy and safety intradermal injections in HIV-infected patients severe received between two six every 4 weeks, according aesthetic results. Clinical evaluated by means ultrasonography photography at...
<h3>Problem:</h3> Drugs are often given intravenously even when the patient is able to swallow and an oral form would be more cost-effective. <h3>Design:</h3> Evaluation of impact a multifaceted intervention on early switch from intravenous administration proton pump inhibitors (PPI) in hospital setting. The interrupted time series PPI consumption was analysed. <h3>Background setting:</h3> At French University Hospital, Drug Committee, composed multidisciplinary pharmacy medical staff,...
Time-dependent receiver operating characteristic curves allow to evaluate the capacity of a marker discriminate between subjects who experience event up given prognostic time from those are free this event. In article, we propose an inverse probability weighting estimator standardized and weighted time-dependent curve. This provides measure capacities by taking into account potential confounding factors. We illustrate robustness simulation-based study its usefulness two applications in...
Early life nutrition is crucial for the development of gut microbiota that, in turn, plays an essential role maturation immune system and prevention infections. The aim this study was to investigate whether feeding synbiotic infants follow-on formulas during first year reduces incidence rate (IR) infectious diarrhea compared with standard formulas. Secondary endpoints included IR other diseases as well fecal milieu parameters. In double-blind, controlled trial, 460 healthy, 1-mo-old were...