A5051602594- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tuberculosis Research and Epidemiology
- Functional Brain Connectivity Studies
- Chronic Kidney Disease and Diabetes
- Mental Health Research Topics
- Lung Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Treatment of Major Depression
- MRI in cancer diagnosis
- Radiation Dose and Imaging
- Diagnosis and treatment of tuberculosis
- Medical Imaging and Pathology Studies
- Mycobacterium research and diagnosis
- Neural and Behavioral Psychology Studies
- Neurological and metabolic disorders
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Cervical Cancer and HPV Research
- Schizophrenia research and treatment
- Infectious Diseases and Tuberculosis
- Body Image and Dysmorphia Studies
- Autism Spectrum Disorder Research
Stellenbosch University
2015-2024
Tygerberg Hospital
2012-2021
University of Cape Town
2011-2015
Southampton General Hospital
2013
Biogen (United States)
2013
AstraZeneca (United Kingdom)
2013
Ninewells Hospital
2013
Queen Mary University of London
2013
Guy's Hospital
2013
Nottingham City Hospital
2013
Biomarkers for tuberculosis treatment outcome will assist in guiding individualized and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing whole blood from a well-characterized TB cohort was performed. Application validated transcriptional correlate risk revealed symmetry host gene expression during progression latent infection to active disease resolution treatment, including return control levels after drug therapy. The also seen signature, constructed the...
Abstract Background Several studies have now examined the effects of selective serotonin reuptake inhibitor (SSRI) treatment on brain function in a variety anxiety disorders including obsessive-compulsive disorder (OCD), posttraumatic stress (PTSD), and social (social phobia) (SAD). Regional changes cerebral perfusion following SSRI been shown for all three disorders. The orbitofrontal cortex (OFC) caudate medial pre-frontal/cingulate (OCD, SAD, PTSD), temporal PTSD) and, thalamic regions...
Introduction Bone scintigraphy is used extensively in evaluating metastatic disease. There are currently no clear recommendations for the use of single photon emission computed tomography (SPECT)/CT bone Given its limited availability there a need to identify clinical indications which SPECT/CT clearly beneficial influencing patient care and outcome. Methods Forty-two patients with equivocal lesions on planar were recruited underwent imaging. On reading SPECT alone then SPECT/CT, classified...
Abstract Background There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during persisting metabolic activity after apparent clinical cure. This poses challenge quantifying scan-based markers burden disease activity. We used semi-automated, whole quantification analyse serial scans from Catalysis TB Treatment Response Cohort identify characteristics that best...
Abstract Background The evolution of tuberculosis (TB) disease during the clinical latency period remains incompletely understood. Methods 250 HIV-uninfected, adult household contacts rifampicin-resistant TB with a negative symptom screen underwent baseline 18 F-Fluorodeoxyglucose positron emission and computed tomography (PET/CT), repeated in 112 after 5-15 months. Following South African WHO guidelines, participants did not receive preventive therapy. All had intensive screening...
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a major contributor to morbidity and mortality in (SLE) patients. To date no single clinical, laboratory or imaging test has proven accurate for NPSLE diagnosis which testament the intricate multifactorial pathophysiological mechanisms suspected exist. Functional with FDG PET-CT shown promise diagnosis, detecting abnormalities prior changes evident on anatomical imaging. Research indicates that may be more aggressive people of African...
Abstract Background World Health Organization (WHO) tuberculosis (TB) screening guidelines recommend computer-aided detection (CAD) software for chest radiograph (CXR) interpretation. However, studies evaluating their diagnostic and prognostic accuracy are limited. Methods We conducted a prospective cohort study of household contacts rifampicin-resistant TB in South Africa. Participants underwent baseline CXR sputum investigation (routine [single spontaneous] enhanced [additionally 2–3...
[99mTc]Hexamethylpropylene amine oxime (HMPAO) single photon emission computed tomography (SPECT) brain scans were undertaken in six subjects with body dysmorphic disorder (BDD). The showed a broad range of discrepant findings that do not immediately support view BDD as resting on either an obsessive-compulsive or affective spectrum. Nevertheless, involvement parietal regions is consistent the characteristic altered perception BDD. These preliminary data highlight need for further systematic...
Methamphetamine dependence can lead to psychotic symptoms which may be mediated by frontal, striatal, limbic, and thalamic regions. There are few neuroimaging data that allow comparison of individuals with methamphetamine who do, do not, have psychosis. Two complementary imaging techniques were employed investigate neurocircuitry associated without symptoms. Three groups participants recruited: dependent (MAA) (N = 11), (MAP) 14), controls 14). Resting brain glucose metabolism was measured...