A5056756670- Iron Metabolism and Disorders
- Gut microbiota and health
- Cell death mechanisms and regulation
- Cell Image Analysis Techniques
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- Child Nutrition and Water Access
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Climate variability and models
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Vaccine Coverage and Hesitancy
- MicroRNA in disease regulation
- interferon and immune responses
- Plant Water Relations and Carbon Dynamics
- Food Security and Health in Diverse Populations
- Antibiotic Resistance in Bacteria
- Hepatitis B Virus Studies
- RNA regulation and disease
- Plant responses to elevated CO2
- Infectious Diseases and Tuberculosis
- Hepatitis Viruses Studies and Epidemiology
- Animal Virus Infections Studies
- PARP inhibition in cancer therapy
The University of Melbourne
2017-2024
Walter and Eliza Hall Institute of Medical Research
2017-2024
Parks Victoria
2024
The Royal Melbourne Hospital
2023
Victorian Infectious Diseases Reference Laboratory
2021-2023
Peter Doherty Institute
2021-2023
Melbourne Health
2021
International Rice Research Institute
2017
Abstract Background The evolution of tuberculosis (TB) disease during the clinical latency period remains incompletely understood. Methods 250 HIV-uninfected, adult household contacts rifampicin-resistant TB with a negative symptom screen underwent baseline 18 F-Fluorodeoxyglucose positron emission and computed tomography (PET/CT), repeated in 112 after 5-15 months. Following South African WHO guidelines, participants did not receive preventive therapy. All had intensive screening...
Abstract Antibiotics may alter the gut microbiome, and this is one of mechanisms by which antimicrobial resistance be promoted. Suboptimal stewardship in Asia has been linked to resistance. We aim examine relationship between oral antibiotic use composition microbiome 1093 Bangladeshi infants. leverage a trial 8-month-old infants rural Bangladesh: 61% children were cumulatively exposed antibiotics (most commonly cephalosporins macrolides) over 12-month study period, including 47% first 3...
Abstract Anemia is highly prevalent globally, especially in young children low-income countries, where it often overlaps with a high burden of diarrheal disease. Distribution iron interventions (as supplements or iron-containing multiple micronutrient powders, MNPs) key anemia reduction strategy. Small studies Africa indicate may reprofile the gut microbiome towards pathogenic species. We seek to evaluate safety and MNPs based on their effects diversity, composition, function rural...
Numerous studies have addressed effects of rising atmospheric CO2 concentration on rice biomass production and yield but crop water use are less well understood. Irrigated evapotranspiration (ET) is composed floodwater evaporation canopy transpiration. Crop coefficient Kc (ET over potential ET, or ETo) specific according to FAO, may decrease as rises. A sunlit growth chamber experiment was conducted in the Philippines, exposing 1.44-m2 canopies IR72 four constant levels (195, 390, 780 1560...
ABSTRACT Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to correct these imbalances achieve remission. However, most patients relapse, suggesting that pathological mechanisms persist during Here, we show excess epithelial cell death an underlying feature of arises in remission on advanced therapy. Mechanistically, nascent inflammation...
Serological diagnostic assays are essential tools for determining an individual's protection against viruses like SARS-CoV-2, tracking the spread of virus in community, and evaluating population immunity. To assess diversity quality anti-SARS-CoV-2 antibody response, we have compared profiles people with mild, moderate, severe COVID-19 using a dot blot assay. The test targeted four major structural proteins namely nucleocapsid (N), spike (S) protein domains S1 S2, receptor-binding domain...
Small extracellular vesicles (SEVs) such as exosomes are released by multiple cell types. Originally believed to be a mechanism for selectively removing unwanted cellular components, SEVs have received increased attention in recent years their ability mediate intercellular communication. Apart from proteins and lipids, contain RNAs, but how RNAs loaded into remains poorly understood. To address this question, we profiled SEV mouse dendritic cells using RNA-Seq identified long noncoding RNA...
Abstract Purpose The COVID PROFILE cohort is a longitudinal clinical study based in Victoria Australia, which was established to understand immunity SARS-CoV-2 low transmission population setting and identify immunological markers of long-term immune-dysregulation after both infection vaccination. Additionally, this as biobank resource for researchers address other health-related questions. Participants We enrolled 178 adult community members, including household contacts, who had either...
Abstract Necroptosis is a lytic form of regulated cell death reported to contribute inflammatory diseases the gut, skin and lung, as well ischemic-reperfusion injuries kidney, heart brain. However, precise identification cells tissues that undergo necroptotic in vivo has proven challenging absence robust protocols for immunohistochemical detection. Here, we provide automated immunohistochemistry detect core necroptosis regulators – Caspase-8, RIPK1, RIPK3 MLKL formalin-fixed mouse human...