A5090548199- Cutaneous Melanoma Detection and Management
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Esophageal and GI Pathology
- HIV-related health complications and treatments
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Economic and Financial Impacts of Cancer
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Breast Implant and Reconstruction
- Esophageal Cancer Research and Treatment
- Palliative Care and End-of-Life Issues
- BRCA gene mutations in cancer
- Colorectal Cancer Surgical Treatments
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Religion, Spirituality, and Psychology
- Cell Image Analysis Techniques
- Immunotherapy and Immune Responses
- Biosimilars and Bioanalytical Methods
- HIV Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cannabis and Cannabinoid Research
Levine Cancer Institute
2015-2019
Carolinas Medical Center
2015-2018
Carolinas Healthcare System
2015-2018
University of North Carolina at Chapel Hill
2012-2013
SSO-ASTRO recently published guidelines defining adequate margins in breast conservation therapy (BCT) as no tumor on ink based studies demonstrating little difference local recurrence (LR) with wider margins. We hypothesize that not routinely re-excising close results decreased costs without compromising care.A decision tree model was developed for the management of after BCT invasive cancer. Patients were compared among three margin status groups: positive, (≤2 mm) and negative (>2 mm)....
Background The association between abacavir (ABC) and cardiovascular disease (CVD) risk in HIV-infected individuals is unclear. Putative mechanisms for an effect of ABC on CVD including endothelial dysfunction have been proposed; however, a biological mechanism has not established. Methods This was cross-sectional study subjects with HIV RNA levels <400 copies/ml, who were randomly assigned to or tenofovir (TDF) as initial therapy during prior clinical trial. A small cohort zidovudine...
Prior to the "no ink on tumor" SSO/ASTRO consensus guideline, approximately 20% of women with stage I/II breast cancers undergoing conservation surgery at our institution underwent margin re-excision. On May 20, 2013, changed definition negative margins from 2 mm tumor."A retrospective review was conducted patients who had clinical between June 1, 2011 and 2015. In pre-guideline cohort (pre) post-guideline (post), were tumor," respectively.Implementation guideline resulted in a significant...
ABSTRACT Racial differences in antiretroviral treatment responses remain incompletely explained and may be a consequence of differential pharmacokinetics (PK) associated with race. Raltegravir, an inhibitor HIV-1 integrase, is commonly used the HIV-infected patients, many whom are African-American. However, there few data regarding PK raltegravir African-Americans. men women, self-described as African-American naive to therapy were treated (RAL) at 400 mg twice day, plus fixed dose...
Neoadjuvant chemotherapy (NAC) reduces tumor size, facilitating the use of breast conservation surgery (BCS). However, mastectomy remains surgical outcome for certain women. The goal this study was to determine rationale after NAC, particularly in women eligible BCS. Retrospective data were reviewed on patients who received NAC between February 2006 and August 2010 at our institution. Demographics characteristics compared BCS NAC. Of 149 meeting inclusion criteria, 102 (68%) underwent 47...
Genetic testing is important for comprehensive cancer care. Commercial analysis of the BRCA1/2 genes has been available since 1996, and hereditary breast ovarian syndrome well established. The National Comprehensive Cancer Network (NCCN) guidelines identify individuals whom appropriate define management recommendations mutation carriers. Despite recommendations, not all who meet NCCN criteria undergo genetic testing. We assess frequency that meeting decline analysis, as factors affect...
Background The seventh edition of the American Joint Commission on Cancer staging manual (AJCC7, published 2009), updated thin cutaneous melanoma protocols with incorporation mitotic rate (MR). In these patients, higher MR is associated decreased survival. This study utilizes National Data Base (NCDB) to evaluate reporting since AJCC7. Methods NCDB was queried for patients primary from 1998 2013. Because infrequent prior implementing AJCC7, records 2010 2013 were analyzed. Categorical...
640 Background: Patients (pts) with synchronous stage IV colorectal cancer commonly begin palliative chemotherapy while the primary tumor remains. Single institution series report low rates of surgical intervention, but this has not been examined nationally. The present study utilizes a large national dataset to examine natural history unplanned intervention in pts on chemotherapy. Methods: SEER-Medicare was queried for metastatic (1998-2009) who underwent resection or diversion (ICD9...
726 Background: Definitive chemoradiotherapy (CHEMORT) is the treatment of choice for anal squamous cell carcinoma (SCC), while surgery typically reserved salvage therapy. Patients (pts) who are frail due to advanced age or medical comorbidities often have difficulty completing Methods: The NCDB was queried pts with SCC (2004-2012). Pts < 50 years, and those in situ metastatic disease, incomplete CHEMORT data were excluded. primary outcome completion CHEMORT. Secondary requirement...
163 Background: Locally advanced gastric adenocarcinoma (GACa) is optimally treated with a combination of surgery, chemotherapy (CHEMO) and radiation (RT). Utilization therapies can vary institutional practices. Methods: The NCDB was queried for pts GACa who had RO resection (2006-2012). Pts metastatic disease, incomplete pathologic staging, CHEMO or RT sequencing data were excluded. divided into groups by treatment regimen: G1: perioperative CHEMO; G2: adjuvant CHEMO±RT; G3: neoadjuvant...
6559 Background: ASCO/NCCN guidelines recommend screening for multifactorial distress in cancer patients. Understanding predictors of related can lead to early intervention and improve clinical outcomes, symptom management, operational efficiency. Through electronic (EDS), patient reported outcomes (PRO) were collected across 42 practice locations. Methods: EDS has 39 questions including: distress, symptoms/side effects, malnutrition, depression, anxiety, social/family support, financial,...