A5019556589- Advanced Machining and Optimization Techniques
- Advanced Surface Polishing Techniques
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Advanced machining processes and optimization
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Pluripotent Stem Cells Research
- Neurotransmitter Receptor Influence on Behavior
- Aquaculture disease management and microbiota
- Developmental Biology and Gene Regulation
- Neurobiology and Insect Physiology Research
- Nicotinic Acetylcholine Receptors Study
- Metal Alloys Wear and Properties
- Forensic Toxicology and Drug Analysis
- Aluminum Alloys Composites Properties
- Psychedelics and Drug Studies
- Neurogenesis and neuroplasticity mechanisms
Shanghai Jiao Tong University
2023-2024
Shanxi Medical University
2023-2024
Ministry of Public Security of the People's Republic of China
2023-2024
State Key Laboratory of Mechanical System and Vibration
2023-2024
Shanghai University
2017-2022
The fish olfactory receptor ORA family is orthologous to the mammalian vomeronasal receptors type 1. It consists of six highly conserved chemosensory expected be essential for survival and communication. We deorphanized zebrafish in a heterologous cell system. responded specifically lithocholic acid (LCA) closely related C24 5β-bile acids/salts. LCA attracted as strongly food behavioral tests, whereas less potent cholanic elicited weaker attraction, consistent with vitro results. ORA-ligand...
Abstract The Notch signaling pathway regulates stem cell proliferation and differentiation in multiple tissues organs, is required for tissue maintenance. However, the role of regulation olfactory epithelium (OE) progenitor/stem cells to maintain function still not clear. A recent study reported that leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) expressed globose basal (GBCs) localized OE. Through lineage tracing vivo, we found Lgr5+ act as generation daughter from...
Lgr5, leucine-rich repeat-containing G-protein coupled receptor 5, is a bona fide biomarker for stem cells in multiple tissues. Lgr5 also expressed the brain, but identities and properties of these + are still elusive. Using an Lgr5-EGFP reporter mouse line, we found that, from early development to adulthood, highly olfactory bulb (OB), area with ongoing neurogenesis. Immunostaining cell, glial, neuronal markers reveals that does not label OB instead labels heterogeneous population neurons...
To investigate the toxicokinetic differences of 3,4-methylenedioxy-
The electrostatic field-induced electrolyte jet (E-Jet) electric discharge machining (EDM) is a newly developed micro method. However, the strong coupling of liquid electrode and induced energy prohibited it from utilization in conventional EDM process. In this study, method with two devices connecting serials proposed to decouple pulse E-Jet By automatic breakdown between tip auxiliary first device, pulsed solid workpiece second device can be generated. With method, charges on indirectly...
Abstract Odorant receptors (ORs) expressed in mammalian olfactory sensory neurons are essential for the sense of smell. However, structure–function studies many ORs hampered by unsuccessful heterologous expression. To understand and eventually overcome this bottleneck, we performed expression functional assays over 80 OR variants chimeras. Combined with literature data machine learning, found that transmembrane domain 4 (TM4) its interactions neighbor residues important The highlight...