Soy isoflavones have been widely used in the treatment of clinical gynecological diseases. The aim this study was to investigate therapeutic effect and molecular mechanism on rats with polycystic ovary syndrome (PCOS). Sprague-Dawley were orally administered 1 mg/kg letrozole for 21 consecutive days induce PCOS rat model. After induction, (100 mg/kg) or metformin (Positive control; 500 continuously 28 days. Then, H&E staining observe pathological changes ovary. serum hormone levels...

Background Given the limited effective treatments for Alzheimer's disease (AD), obesity and serum uric acid (SUA) levels which are considered modifiable risk factors dementia of interest. However, research indicates conflicting results. Objective We aimed to further investigate association body weight (BW) SUA with AD biomarkers cognitive impairment. Methods Clinical data were collected from 139 adults (mean age 66.9 years) chronic Cerebrospinal fluid (CSF) PET imaging used assess amyloid-β...

Pulmonary artery thrombosis in neonates is a rare entity. We describe neonate with this diagnosis as well his presentation, evaluation, and management. This case highlights the importance of cardiac ultrasound screening for high risk factors pulmonary without clinical symptoms, it not easily detected. Here, we present an unusual Chinese premature infant, born to diabetic mother, whom developed main 12 days after exploratory laparotomy. The preterm infant had no manifestations thrombosis,...

To assess the value of contrast-enhanced ultrasonography (CEUS) for monitoring disease activity Takayasu arteritis (TA). TA patients were recruited in a Chinese clinical center from January 2016 to September 2017. The physician global assessment was used as referential standard activity. Clinical data, acute phase reactants, and CEUS scans simultaneously recorded at baseline after 3-month therapy. A total 84 enrolled, 47 (55.95%) cases active baseline. Macaroni sign entire artery involvement...

Henoch-Schönlein purpura nephritis (HSPN) shares many similarities with IgA nephropathy. We aimed to analyze the predictive value of International Study Kidney Disease in Children (ISKDC) classification and updated Oxford for nephropathy HSPN patients.Data 275 patients (aged≥14 years) were retrieved, all them underwent a renal biopsy. re-classified biopsies according ISKDC their correlations clinical features outcomes. The endpoints defined as ≥30% reduction baseline estimated glomerular...

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) improve the clinical outcomes of EGFR-mutant non-small cell lung cancer (NSCLC) patients significantly, however, acquired resistance occurs almost inevitably. The underlying mechanisms osimertinib and treatment strategies after remain largely unknown. Here we reported a case adenocarcinoma patient who progressed on with EGFR L718Q mutation in absence T790M mutation. received icotinib as an exploratory regimen for short...

We describe an outbreak of echovirus 18 infection involving 10 patients in our neonatal intensive care unit (an attack rate 33%). The mean age at the onset illness was 26.8 days. Eighty percent were preterm infants. All discharged home without sequelae. There no differences gestation age, birth weight, delivery mode, use antibiotics, and parenteral nutrition between enterovirus (EV) group non-EV group, but breastfeeding significantly higher EV group. Separation reinforcement hand-washing...

Age plays a crucial role in the interplay between tumor and host, with additional impact due to irradiation. Proton irradiation of tumors induces biological modulations including inhibition angiogenic immune factors critical 'hallmark' processes impacting development. has also provided promising results for proton therapy cancer targeting advantages. Additionally, protons may contribute carcinogenesis risk from space travel (due high proportion high-energy radiation). Through systems biology...

This study aimed to investigate the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and retinopathy of prematurity (ROP) in premature infants one month after birth.

Abstract This study aimed to further understand the role of relative telomere length (RTL) in susceptibility gastric carcinoma (GC) and investigate association between genetic polymorphisms related genes GC risk. RTL was measured using real-time quantitative polymerase chain reaction from 1000 patients 1100 healthy controls. Genotyping performed Agena MassARRAY platform. The statistical analysis chi-square/ Welch T tests, Mann–Whitney U test, logistic regression analysis. showed that case...

Abstract Objective As the predominant complication in preterm infants, Bronchopulmonary Dysplasia (BPD) necessitates accurate identification of infants at risk and expedited therapeutic interventions for an improved prognosis. This study evaluates potential Monosaccharide Composite (MC) enriched with environmental information from circulating glycans as a diagnostic biomarker early-onset BPD, and, concurrently, appraises BPD premature neonates. Materials methods The incorporated 234 neonates...

To investigate the causal relationship between human papillomavirus (HPV) and lung cancer, we conducted a study using two-sample Mendelian randomization (TSMR).

Pyroptosis, a specific type of programmed cell death, which has become significant factor to Parkinson's disease (PD). Concurrently, long non-coding RNAs (lncRNAs) have garnered attention for their regulatory roles in neurodegenerative disorders. This study was designed ascertain the key lncRNAs pyroptosis pathways PD and elucidate mechanisms. Employing combination bioinformatics machine learning, we analyzed data sets GSE133347 GSE110716. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes...

Objective To characterize Takayasu arteritis (TA) with supra-aortic involvement and determine the associations between clinical features, carotid ultrasonographic (US) variables, neurological severe ischemic events (SIEs). Methods Patients including brachiocephalic trunk, bilateral common artery internal artery, subclavian vertebral baseline US examination were enrolled from East China TA cohort. Bilateral diameter, intima-media thickness (IMT), peak systolic velocity (PSV) measured by US....

Congenital nephrotic syndrome (CNS), which is defined as heavy proteinuria, hypoalbuminemia, hyperlipidemia and edema, most caused by monogenic defects in structural proteins of the glomerular filtration barrier kidneys. 22q11.2 duplication was a chromosomal disease with variable clinical featuresranging from normal to mental retardation congenital defects. Co-occurrence two genetic disorders single patient rare. The proband born at 36 weeks gestational age spontaneously weighed 2350 g...

To study the efficacy of capecitabine or S-1 plus oxaliplatin (CAPOX SOX) for treating thymidine phosphorylase (TP)- dihydropyrimidine dehydrogenase (DPD)-positive advanced gastric cancer.Eighty-six patients with stage IIIC to IV cancer were assessed TP and DPD expression by immunohistochemistry. The association between CAPOX SOX TP/DPD was retrospectively analyzed.There no significant differences in objective remission rate (ORR, 52.27% vs. 47.62%; P>0.05), disease control (72.73% 73.81%,...

Confined water inrush is one of the important problems in foundation pit engineering. How to control confined always focus research. Taking a project Hangzhou as an example, this paper briefly expounds measures. It found that, according relevant norms and local experience, measures hanging waterproof curtain with pit-in-pit reinforced have been adopted successfully, which could provide wealth experience guidance for design construction future similar deep excavation projects.