A5088240293- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Gout, Hyperuricemia, Uric Acid
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Cerebrovascular and Carotid Artery Diseases
- Urticaria and Related Conditions
- IgG4-Related and Inflammatory Diseases
- Case Reports on Hematomas
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- interferon and immune responses
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Animal Virus Infections Studies
- Sarcoidosis and Beryllium Toxicity Research
- Hemoglobinopathies and Related Disorders
- Renal and Vascular Pathologies
- Erythrocyte Function and Pathophysiology
- Chemical synthesis and alkaloids
- Animal Disease Management and Epidemiology
- Coronary Artery Anomalies
Fudan University
2016-2025
Zhongshan Hospital
2016-2025
Shantou University
2022-2023
Yue Bei People's Hospital
2022-2023
The First Affiliated Hospital, Sun Yat-sen University
2016-2022
Sun Yat-sen University
2016-2022
Qingdao University
2022
Affiliated Hospital of Qingdao University
2022
Southern Medical University
2021-2022
Nanfang Hospital
2021-2022
Abstract Previous studies have shown that dysregulation of microRNA-150 (miR-150) is associated with aberrant proliferation human non-small cell lung cancer (NSCLC) cells. However, whether miR-150 has a critical role in NSCLC metastasis unknown. Here, we reveal the pro-metastatic regulation epithelial-mesenchymal-transition (EMT) through down-regulation FOXO4 NSCLC. In vitro , targets 3′UTR region mRNA, thereby negatively regulating its expression. Clinically, expression was frequently...
Cisplatin resistance is a major therapeutic challenge in non-small cell lung cancer (NSCLC). Herein, the regulatory role of long non-coding RNA (lncRNA) ITGB2-AS1 regulating NSCLC cisplatin was investigated. cells were constructed using A549 and H1975 cells. Cell viability proliferation detected by MTT assay colony formation assay, respectively. apoptosis cycle examined flow cytometry. GSH, MDA, ROS, Fe2+ levels measured corresponding kits. The expressions ferroptosis-negative regulation...
Lycorine, a natural alkaloid extracted from Amaryllidaceae, has shown various pharmacological effects. Recent studies have focused on the potential antitumor activity of lycorine. In our previous study, we found that lycorine decrease cell viability leukemia HL-60 cells and multiple myeloma KM3 induces apoptosis. However, effect molecular mechanism human chronic myelocytic yet to be determined.Human K562 were treated with Cell was monitored using method CCK-8. The histone deacetylase (HDAC)...
To compare the treatment efficacy and safety of tofacitinib (TOF) versus methotrexate (MTX) in Takayasu arteritis (TAK).Fifty-three patients with active disease from an ongoing prospective TAK cohort China were included this study. Twenty-seven treated glucocorticoids (GCs) TOF, 26 GCs MTX. The observation period was 12 months. Complete remission (CR), inflammatory parameter changes, tapering assessed at 6th, 9th 12th month. Vascular lesions evaluated 6th month, relapse analysed during...
Infection is a leading cause of mortality in idiopathic inflammatory myopathies (IIMs). This study aimed to develop nomogram for predicting severe infection risk IIM patients. Patients with IIMs admitted Zhongshan Hospital, Fudan University, from January 2015 2022 were enrolled. They randomly divided into derivation (70%) and validation (30%) sets. Univariate multivariate Cox regression identified independent factors infection, the Akaike information criterion (AIC) was applied model...
To assess the value of contrast-enhanced ultrasonography (CEUS) for monitoring disease activity Takayasu arteritis (TA). TA patients were recruited in a Chinese clinical center from January 2016 to September 2017. The physician global assessment was used as referential standard activity. Clinical data, acute phase reactants, and CEUS scans simultaneously recorded at baseline after 3-month therapy. A total 84 enrolled, 47 (55.95%) cases active baseline. Macaroni sign entire artery involvement...
Abstract Objectives In IgG4-related disease, the relationship between pathological findings and relapse has not been well established. This study aimed to identify clinical predictors of disease in IgG4-RD. Methods Patients with newly diagnosed IgG4-RD ( n = 71) were enrolled January 2011 April 2020; all cases pathologically confirmed. The features recorded a database at baseline each follow-up visit. followed up least once month via outpatient clinic examinations telephone calls. Univariate...
// Zhiwei Sun 1 , Ye Wang Xu Han Xielan Zhao 2 Yuanliang Peng Yusheng Li Minyuan Jianhui Song Kunlu Wu Shumin Weihua Zhou Biwei Qi Chufan Huiyong Chen Xiuli An 3, 4 Jing Liu The State Key Laboratory of Medical Genetics & School Life Sciences, Central South University, Changsha 410078, China Xiangya Hospital, 410008, 3 College Zhengzhou 450001, Membrane Biology, New York Blood Center, York, NY 10065, USA Correspondence to: Liu, e-mail: liujing2@sklmg.edu.cn An, xan@nybloodcenter.org Chen,...
Background: The mechanisms of remarkable storiform fibrosis and high levels IgG4 with a pathogenic germinal center (GC) formation in the inflammatory tissue IgG4-RD remains unknown may be responsible for unsatisfactory therapeutic effect using conventional therapy. Objectives: To investigate mechanism interleukin 6 (IL-6) inducing fibroblasts to produce cytokines GC development IgG4-related disease (IgG4-RD). Methods: clinical data laboratory examinations 56 patients were collected. IL-6...
Abstract Background Takayasu arteritis (TA) is a large vessel vasculitis that can involve pulmonary arteries (PAs). We studied multiple clinical characteristics related to artery involvement (PAI) in TA patients. Methods enrolled 216 patients with from prospective cohort. PAI was assessed each patient based on data magnetic resonance angiography/computed tomography angiography. Pulmonary hypertension, cardiac function, and parenchymal lesions were evaluated further echocardiography, the New...
Abstract Objectives To investigate features of urate deposition in gout and the association between these attacks gouty arthritis using dual‐energy computed tomography ( CT ). Methods Dual‐energy scans both feet were performed 80 consecutive patients with 22 asymptomatic hyperuricemia. Results Overall, 333 areas found gout. The most commonly affected sites first metatarsophalangeal joint MPJ ; 57/333), distal area toe (59/333) calcaneal bone (61/333). For episodes arthritis, deposits flexor...
Abstract Objective This study aimed to compare the efficacy and safety of adalimumab (ADA) vs tocilizumab (TCZ) in patients with Takayasu arteritis (TAK). Methods was a randomized, controlled, open-label study. Forty active severe TAK were enrolled. They treated ADA (n = 21) combined glucocorticoids (GCs) MTX or TCZ 19) GCs MTX. The planned follow-up duration 12 months. primary end point rate (ER) at 6 secondary points included ER 9 months, relapse rate, GC tapering, adverse effects, life...
The study investigates the effectiveness and safety of methotrexate (MTX) versus leflunomide (LEF) in 12-month treatment Takayasu arteritis (TAK).This was a cohort study. Patients diagnosed with TAK between 1 January 2013 2019 were enrolled from First Hospital China Medical University Zhongshan Fudan University. had active disease treated glucocorticoid combined LEF or MTX. Treatment response, imaging assessment side-effects evaluated during follow-up.In total, 68 patients (40 cases 28 MTX)....
Takayasu arteritis (TA) is a rare disease, lacking convenient and feasible biomarkers to identify disease activity. We aimed evaluate the value of complements in distinguishing active TA.Consecutive patients were enrolled from prospective East China TA cohort April 2008 June 2019. Patients divided into two groups according their baseline Kerr score. The other identifying activity analysed with cluster analysis, ROC curves, combined tests. An independent group July 2019 December employed...
Abstract Background Takayasu arteritis (TAK) is a chronic granulomatous large vessel vasculitis with multiple immune cells involved. Chemokines play critical roles in recruitment and activation of cells. This study aimed to investigate chemokine profile the peripheral blood vascular tissue patients TAK. Methods A total 58 TAK 53 healthy controls were enrolled. Chemokine array assay was performed five three controls. higher levels preliminarily validated 20 The chemokines further confirmed...
Abstract Objective To investigate the relationships between changes in serum urate levels and dual‐energy computed tomography ( DE ‐ CT ) results during urate‐lowering therapy ULT to effects of treatment duration drugs on results. Methods Forty‐four patients diagnosed with gout were enrolled this investigation. was conducted foot at baseline end follow‐up (6–24 months). Crystals classified as: (i) L , number large crystals diameter ≥ 3 mm; (ii) S small < (iii) T total crystals; (iv) Vmax,...