A5101533713- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Alzheimer's disease research and treatments
- Curcumin's Biomedical Applications
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Air Quality and Health Impacts
- Energy and Environment Impacts
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Biochemical and Molecular Research
- Hormonal Regulation and Hypertension
- Microtubule and mitosis dynamics
- Climate Change and Health Impacts
- Renin-Angiotensin System Studies
- Retinoids in leukemia and cellular processes
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Air Quality Monitoring and Forecasting
- Cholangiocarcinoma and Gallbladder Cancer Studies
Shantou University
2023
Yue Bei People's Hospital
2023
First Affiliated Hospital of Zhengzhou University
2013-2020
Harbin Medical University
2019
Second Affiliated Hospital of Harbin Medical University
2019
Shenzhen Center for Disease Control and Prevention
2018
Southern Medical University
2016-2017
Ruijin Hospital
2011
Zhengzhou University
2011
China University of Mining and Technology
2009
Cisplatin resistance is a major therapeutic challenge in non-small cell lung cancer (NSCLC). Herein, the regulatory role of long non-coding RNA (lncRNA) ITGB2-AS1 regulating NSCLC cisplatin was investigated. cells were constructed using A549 and H1975 cells. Cell viability proliferation detected by MTT assay colony formation assay, respectively. apoptosis cycle examined flow cytometry. GSH, MDA, ROS, Fe2+ levels measured corresponding kits. The expressions ferroptosis-negative regulation...
MiR-214 is aberrantly regulated in several tumours, but its underlying mechanisms colorectal cancer (CRC) metastasis remain largely unknown. This study aimed to demonstrate the function and potential mechanism of miR-214 regulating invasion CRC. The transcription factor targets were predicted by bioinformatics validated using ChIP dual-luciferase reporter assay. DNA methylation status was explored bisulphite sequencing PCR. vitro vivo CRC evaluated MTT, plate colony formation, Matrigel...
Nowadays, air pollution is a severe environmental problem in China. To investigate the effects of ambient on health, time series analysis daily outpatient and inpatient visits 2015 were conducted Shenzhen (China). Generalized additive model was employed to analyze associations between six pollutants (namely SO2, CO, NO2, O3, PM10, PM2.5) after adjusting confounding meteorological factors, day week effects. Significant two types hospital observed. The estimated increase overall associated...
Cysteine-rich intestinal protein 1 (CRIP1), a member of the LIM/double zinc finger family, is abnormally expressed in several tumour types. However, few data are available on role CRIP1 cancer. In present study, we aimed to investigate expression profile and functions colorectal cancer.To examine level CRIP1, immunohistochemistry (IHC) was performed 56 pairs colon cancer tissue samples. Western blotting four cell lines. The endogenous suppressed using short interfering RNAs (siRNAs). Cell...
Abstract The biological function and underlying mechanism of microRNA‐628‐5p (miR‐628‐5p) remains to be clarified in the growth progression pancreatic ductal adenocarcinoma (PDAC). Here, expression levels miR‐628‐5p PDAC tissues cells were detected by quantitative reverse transcriptase polymerase chain reaction situ hybridization. relationship between clinicopathologic characteristics was examined human tissue samples. Gain‐ loss‐of‐function putative targets evaluated cell lines. upstream...
Abstract Hypoxic pulmonary hypertension (HPH) is a lethal disease. CircRNAs and m 6 A circRNAs have been reported to be associated with cancer progression, but the expression profiling of has not identified in HPH. This study was investigate transcriptome-wide map In this study, hypoxia-induced PH rat model established. Total RNA extracted purified from lungs rats, then were detected annotated by RNA-seq analysis. Immunoprecipitation (MeRIP) performed following rRNA depletion, library...
Ambient particulates play an important role in human health; numerous studies have related ambient levels with adverse health outcomes, primarily respiratory-related, the general population. The effect is closely correlated properties of particulates, toxicology mechanism studied on molecular level by means biology method mostly, vitro plasmid assay together FESEM (Field emission scanning electron microscopy) and ICP-MS (inductively coupled plasma-mass spectrometry) were employed to...
Objective To investigate the in vivo effect of silenced actin-associated protein Transgelin on growth human pancreatic carcinoma xenograft nude mice.Methods Human cancer cell line BxPC3 were transfected with small hairpin RNA (shRNA) eukaryotic expression vector targeting gene.RT-PCR and Western blot used to analyze after transfection.24 animal models randomly divided into three groups 8 each:Experimental group (transplanted BxPC3/Transgelin shRNA),negative control BxPC3/Neo) untreated...