Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common type of tumors, accounting for more than half (NENs). We performed a retrospective study in our center to investigate clinicopathological features, risk factors metastasis, and prognosis GEP-NENs Chinese population.Four hundred forty patients with treated at First Affiliated Hospital Zhengzhou University between January 2011 March 2016 were analyzed retrospectively. Multivariate logistic regression was identify...

Abstract Patients who suffer from gastro‐entero‐pancreatic neuroendocrine neoplasms (GEP‐NENs) often present with liver metastatic disease. The efficacy of primary tumor resection (PTR) for these patients remains controversial due to the relatively heterogeneous behavior and lack clinical evidence. In this series, GEP‐NEN metastases (LM) were selected Surveillance, Epidemiology, End Results database between 2010 2015. A logistic regression model was used analyze variables that associated...

Transgelin is a known actin-binding protein, which plays role in regulating the functions of smooth muscle cells or fibroblasts. Recent evidence indicates that transgelin involved diverse human cancers, yet its pancreatic cancer remains unclear. We therefore evaluated expression characteristics and function cancer. Immunohistochemical analysis benign (n = 30 patients) malignant 114 ductal showed significantly higher staining cells. Lymph node metastasis (P 0.026) diabetes 0.041) were shown...

Gastric intestinal metaplasia (IM) induced by bile acid is a precancerous lesion of gastric adenocarcinoma and associated with the expression caudal-related homeobox 2 (CDX2). In present study, role farnesoid X receptor (FXR) on regulation CDX2 in cells was investigated underlying molecular mechanisms were examined. Human cell lines treated chenodeoxycholic (CDCA) or FXR agonist GW4064. Cells CDCA presence absence antagonist siRNA transfection. Next, SHP transfection FXR, mRNA protein levels...

Introduction: Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare form of neoplasms. The purpose this study was to investigate the characteristics and survival profile appendiceal MiNENs, with view providing robust clinical features disease. Methods: Patients were selected from Surveillance, Epidemiology End Results database (2004-2016). prognosis MiNEN (n=315) compared other histological subtypes including tumor (n=1734), carcinoma (n=375), goblet cell carcinoid (n=968),...

Aim: The effects of different types gastric neuroendocrine tumors (G-NETs) on treatment strategy formulation and prognostic evaluation still remain controversial due to their rarity. Methods: 187 patients diagnosed with G-NETs were subdivided into four based the pathophysiology, etiology presentation. Results: Type I, II >1.0 cm type III, IV >2.0 are proved aggressive behavior (p < 0.05). III higher Ki-67 index tumor stage showed more invasive potential than I Endoscopic resection is primary...

Context: Given that Pinus massoniana Lamb (Pinaceae) bark extract (PMBE) is a safe and non-toxic flavonoid found abundantly in nature, it was considered promising novel candidate agent the treatment of virus infection.Object: Experiments were conducted to assay antiviral character PMBE against Hepatitis C (HCV).Materials methods: Assay cytotoxicity, HCV replication, infectious production, its potential influence on pathways for IFN-ISRE NS3 protease conducted.Results: replication suppressed...

BACKGROUND Patients with liver cancer complicated by portal hypertension present complex challenges in treatment. AIM To evaluate the efficacy of radiofrequency ablation combination sorafenib for improving function and its impact on prognosis patients this condition. METHODS Data from 100 May 2014 to March 2019 were analyzed divided into a study group (n = 50) control according treatment regimen. The research received (RFA) sorafenib, only RFA. short-term both groups was observed. Liver...

Nonalcoholic fatty liver disease (NAFLD) is a prevalent with high morbidity. Omarigliptin novel antidiabetic drug that inhibits dipeptidyl peptidase-4 and alleviates inflammation insulin resistance. In the present study, anti-inflammatory antioxidative stress property of omarigliptin will be investigated to explore potential therapeutic effects on NAFLD in mice models. A high-fat diet (HFD) was used induce model mice. Hematoxylin-eosin staining detection concentrations total cholesterol (TC)...

Objective To explore the clinicopathologic characteristics, to screen risk factors of metastasis and analyze diagnosis, treatment prognosis gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN). Methods From January 2010 November 2015, clinical data 405 patients with GEP-NEN were retrospectively analyzed. tumors classified as tumor (NET, G1 G2 grade), carcinoma (NEC, G3 grade) mixed adenoendocrine (MANEC, grade). The characteristics summarized. staining synaptophysin (Syn),...

Objective To evaluate the efficacy and safety of atorvastatin in treatment patients with non-alcoholic fatty liver disease(NAFLD).Methods Of 72 NAFLD6,8 elevated alanine transaminase(ALT)and cholesterol levels at baseline had completed study.The were randomly divided into trial group(n=38)and control group(n=30,ithout any treatment).The group orally received 10 or 20 mg daily according to basal serum being≤or＞6.5 mmol/L,respectively.The parameters including body mass index,serum level ALT...