A5017190999- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Management of metastatic bone disease
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Reproductive Physiology in Livestock
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Spine and Intervertebral Disc Pathology
- Ubiquitin and proteasome pathways
- Spinal Fractures and Fixation Techniques
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Sperm and Testicular Function
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Bone Tumor Diagnosis and Treatments
- Cancer Mechanisms and Therapy
- interferon and immune responses
Tianjin Medical University Cancer Institute and Hospital
2015-2025
Shaoxing University
2022-2024
Ministry of Agriculture and Rural Affairs
2021-2024
Huazhong Agricultural University
2021-2024
Qinghai University
2022-2024
Chinese Academy of Sciences
2019-2023
National Clinical Research
2013-2023
First Affiliated Hospital of Bengbu Medical College
2008-2023
Xinjiang Institute of Ecology and Geography
2019-2023
University of Chinese Academy of Sciences
2020-2023
The mitochondria-mediated caspase activation pathway is a major apoptotic characterized by mitochondrial outer membrane permeabilization (MOMP) and subsequent release of cytochrome c into the cytoplasm to activate caspases. MOMP regulated Bcl-2 family proteins. This plays important roles not only in normal development, maintenance tissue homeostasis regulation immune system, but also human diseases such as disorders, neurodegeneration cancer. In past decades molecular basis this regulatory...
Abstract Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis type iron-mediated cell death that can suppress liver transformation. Previous studies have linked HBV to ferroptosis in fibrosis and acute failure. However, whether involved HBV-mediated cancer poorly understood. Here, we identified heat shock protein family A member 8 (HSPA8) as crucial host factor modulates replication cancer. X (HBx) upregulated HSPA8 by coactivating the transcription 1...
Abstract Background Colorectal cancer (CRC) is a major burden, and prognosis determined by many demographic clinicopathologic factors. The present study aimed to construct prognostic nomogram for colorectal patients with distant metastasis. Methods metastasis diagnosed between 2010 2016 were selected from the Surveillance, Epidemiology, End Results database. Cox proportional hazards regression was used identify independent A constructed predict survival, validation performed. total of 7099...
Malignant bone tumors are a group of rare malignant and our study aimed to update the recent epidemiologic estimates based on Surveillance, Epidemiology End Results database. Patients diagnosed with from 2000 2019 were included their characteristics retrospectively described. The limited-duration prevalence, annual age-adjusted incidence mortality calculated, percentage changes analyzed quantify rate change. Finally, observed survival relative illustrated. Subgroup analysis across tumor...
Abstract Background The yak is a symbol of the Qinghai-Tibet Plateau and provides important basic resources for human life on plateau. Domestic yaks have been subjected to strong artificial selection environmental pressures over long-term. Understanding molecular mechanisms phenotypic differences in populations can reveal key functional genes involved domestication process improve genetic breeding. Material method Here, we re-sequenced 80 (Maiwa, Yushu, Huanhu populations) identify...
Abstract Background Hypoxia mediated pulmonary hypertension (HPH) is a lethal disease and lacks effective therapy. CircRNAs play significant roles in physiological process. Recently, circRNAs are found to be m 6 A-modified. The abundance of was influenced by A. Furthermore, the significance A has not been elucidated HPH yet. Here we aim investigate transcriptome-wide map HPH. Results Differentially expressed detected lungs rats. M significantly reduced hypoxia vitro. were mainly from...
Abstract To gain a deeper understanding of the metabolic differences within and outside body, as well changes in transcription levels following estrus yaks, we conducted transcriptome metabolome analyses on female yaks both non-estrus states. The analysis identified 114, 13, 91 distinct metabolites urine, blood, follicular fluid, respectively. Kyoto Encyclopedia Genes Genomes (KEGG) highlighted an enrichment pathways related to amino acid lipid metabolism across all three body fluids. Our...
Abstract BACKGROUND Early weaning in yak calves is being attempted to improve reproduction rate. However, this has be done with caution because of the high mortality rate due lack nutrients and harsh environmental conditions. Twenty‐four weaned male were used a 60 day feeding trial which astragalus root extract (ARE) was supplemented. They assigned randomly one four dietary treatments ( n = six per treatment) that differed ARE level: 0 g kg −1 (control), ; 20 , 50 50; 80 dry matter intake...
Hepatocellular carcinoma (HCC) is one of the most prevalent causes cancer-related morbidity and mortality worldwide. Late-stage detection complex molecular mechanisms driving tumor progression contribute significantly to its poor prognosis. Dysregulated R-loops, three-stranded nucleic acid structures associated with genome instability, play a key role in malignant characteristics various tumors. However, detailed mechanism R-loops HCC remain elusive require further exploration. This study...
Osteosarcoma is a highly aggressive bone disease with tendency to metastasize the lung. The 5-year survival of patients metastatic osteosarcoma only 20 %. Many studies have demonstrated SDF-1/CXCR4 and MMP9 play important roles in metastasis malignant tumors, including osteosarcoma. aim this study was investigate association CXCR4 expression clinicopathological features pulmonary Using tumor tissue microarrays, we analyzed among 34 primary osteosarcomas 62 without metastasis. A median time...
Sertoli cells are the major component of spermatogonial stem cell (SSC) niche; however, regulatory mechanisms in that dictate SSC fate decisions remain largely unknown. Here we revealed features N6-methyladenosine (m6A) mRNA modification and demonstrated functions WTAP, key subunit m6A methyltransferase complex spermatogenesis. m6A-sequencing analysis identified 21,909 sites from 15,365 putative m6A-enriched transcripts within 6,122 genes, including many cell-specific genes. Conditional...
Abstract Distant metastasis is the primary cause of breast cancer-associated death. The existing information, such as precise molecular mechanisms and effective therapeutic strategies targeting metastasis, insufficient to combat cancer. This study demonstrates that protein tyrosine phosphatase PTPN18 downregulated in metastatic cancer tissues associated with better metastasis-free survival. Ectopic expression inhibits cell metastasis. translocated from cytoplasm nucleus by MVP importin β2...
Anoikis, a form of apoptosis that occurs due to detachment cells from the extracellular matrix, has been linked development cancer in several studies. However, its role pancreatic remains incompletely understood. In this study, we utilized univariate Cox regression and LASSO analyses establish prognostic model for adenocarcinoma based on anoikis-related genes TCGA database. Additionally, performed multifactorial protein expression results adenocarcinoma. We further explored difference immune...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor response to all therapeutic modalities and dismal prognosis. The presence of tertiary lymphoid structures (TLSs) in various solid cancers crucial prognostic significance, highlighting the intricate interplay between tumor microenvironment immune cells aggregation. However, extent which TLSs status affect PDAC prognosis remains incompletely understood. Here, we sought unveil unique properties leveraging both single-cell...
To investigate associations between WW domain-containing oxidoreductase (WWOX), runt-related transcription factor 2 (RUNX2) and vascular endothelial growth alpha (VEGFA) in human osteosarcoma (OS). Copy number aberrations of WWOX, RUNX2and VEGFA genes were detected by microarray comparative genomic hybridization (aCGH) 10 fresh OS tissue samples. gene alterations also investigated validated fluorescence situ (FISH) 54 formalin-fixed paraffin-embedded (FFPE) Protein expression RUNX2 examined...