A5102921462- Genomic variations and chromosomal abnormalities
- Chromosomal and Genetic Variations
- Genetic factors in colorectal cancer
- Genomics and Chromatin Dynamics
- Reproductive Physiology in Livestock
- Prenatal Screening and Diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Endometriosis Research and Treatment
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- GDF15 and Related Biomarkers
- DNA Repair Mechanisms
- Effects of Environmental Stressors on Livestock
- Mitochondrial Function and Pathology
- Fibroblast Growth Factor Research
- Circular RNAs in diseases
- Muscle Physiology and Disorders
- Reproductive System and Pregnancy
- Congenital heart defects research
- Genetic Mapping and Diversity in Plants and Animals
- Molecular Biology Techniques and Applications
Northwest A&F University
2019-2025
Abstract To gain a deeper understanding of the metabolic differences within and outside body, as well changes in transcription levels following estrus yaks, we conducted transcriptome metabolome analyses on female yaks both non-estrus states. The analysis identified 114, 13, 91 distinct metabolites urine, blood, follicular fluid, respectively. Kyoto Encyclopedia Genes Genomes (KEGG) highlighted an enrichment pathways related to amino acid lipid metabolism across all three body fluids. Our...
Copy number variation (CNV) is a form of genetic caused by genome rearrangement, with abnormal fragments ranging from 50 bp to Mb. And, CNV closely related disease, growth and reproductive shape livestock. As member myosin light chain kinase (MYLK) family serine/threonine specificity, MYLK4 belongs an enzyme encoded gene. Although recognized kinase, its function has yet be revealed in subsequent studies. This study aims analyze effects gene goats. We used qPCR detect African Nubian goat (n =...
(1) Background: Copy number variation (CNV) is a critical component of genome structural and has garnered significant attention. High-throughput screening the KCNJ15 gene revealed correlation between CNV region growth traits goats. We aimed to identify in five goat breeds analyze its association with characteristics. (2) Methods: utilized 706 goats from breeds: Guizhou black (GZB), white (GZW), Bohuai (BH), Huai (HH), Taihang (TH). To evaluate copies using qPCR, we analyzed characteristics...
Abstract Circular RNA (circRNA), a stable ring‐shaped molecule found in eukaryotic cells, plays significant roles biological regulation, particularly by interfering with transcription factor binding or enhancing gene expression. Using transcriptomic sequencing, we identified differentially expressed circRNAs bovine muscle at various time points. Specifically, circDYRK1A was discovered and shown to enhance differentiation while suppressing proliferation of adult myoblasts. Rescue experiments...
Lipopolysaccharide (LPS) is one of the main factors inducing endometritis in dairy cows. However, specific pathogenesis LPS-induced cows not fully understood. The objective this study was to establish an vitro model using bovine endometrial epithelial (BEND) cells. BEND cells were treated with LPS different concentrations and times. cell-counting kit-8 (CCK-8) used detect cell survival rate after treatment, quantitative real-time PCR (RT-qPCR) expression control group LPS-treated...
Abstract Background Generally, copy number variation (CNV) is a large‐scale structural between 50 bp and 1 kb of the genome. It can affect gene expression an important reason for genetic diversity phenotypic trait diversity. Studies have shown that eukaryotic translation initiation factor 4A2 ( EIF4A2 ) plays essential role in muscle development both humans pigs. However, influence bovine ’s change on traits has not been reported. Objectives To detect tissue profile adult cattle individuals’...
Abstract Background Copy number variation (CNV) has become an essential part of genetic structural variation. Coiled‐coil domain containing 39 ( CCDC39 ) is a gene that related to the growth and development organs tissues. It identified it CNV region by animal genome resequencing. Objective In this study, we detected phenotypic traits different distributions copy numbers in five Chinese cattle breeds (Qinchuan (QC) cattle, Yunling (YL) Xianan (XN) Pinan (PN) Jiaxian (JX) cattle). Methods...
The aim of this study was to detect the novel copy number variation (CNV) locus NCAM2 gene in Chinese Holstein, and analyze effect CNV on milk composition traits. 310 Holstein detected by real-time quantitative fluorescent PCR (qPCR) association analysis performed between traits Holstein. There are three types Holstein: gain (increased number), median (normal number) loss (deleted number). Statistical revealed that there a significant fat rate (p < 0.05). Moreover, we also discovered...
Previous researches revealed a copy number variation (CNV) region in the bovine fibroblast growth factor 13 (FGF13) gene. However, its effects remain unknown. This study detected various types seven Chinese cattle breeds and analysed their population genetic characteristics on traits transcription levels. Copy Loss was more frequent Caoyuan Red Xianan than other breeds. Association analysis between CNV of Qinchuan indicated that significantly related to chest depth, hip width hucklebone (P <...
DNA polymerase β (DNA beta (POLB)) belongs to a member of the X family, mainly involved in various biological metabolic processes, such as eukaryotic replication, damage repair, gene recombination, and cell cycle regulation. In this study, muscle development-related POLB was screened by selection signature RNA-seq analysis then validated for proliferation apoptosis bovine primary myocytes. It also found that overexpression had pro-apoptosis effect, but interfering with expression no...