A5100335595- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Statistical Methods in Clinical Trials
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
- HIV Research and Treatment
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- BRCA gene mutations in cancer
- DNA and Nucleic Acid Chemistry
Zhejiang University
2020-2025
Hangzhou Normal University
2022-2024
Zhejiang Provincial People's Hospital
2024
Nanjing University of Posts and Telecommunications
2024
Tianjin Medical University Cancer Institute and Hospital
2022-2024
Jiangsu Agri-animal Husbandry Vocational College
2024
First Affiliated Hospital of Chengdu Medical College
2024
Sun Yat-sen University
2021-2024
The University of Texas MD Anderson Cancer Center
2022-2024
Fox Chase Cancer Center
2024
Abstract Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis type iron-mediated cell death that can suppress liver transformation. Previous studies have linked HBV to ferroptosis in fibrosis and acute failure. However, whether involved HBV-mediated cancer poorly understood. Here, we identified heat shock protein family A member 8 (HSPA8) as crucial host factor modulates replication cancer. X (HBx) upregulated HSPA8 by coactivating the transcription 1...
Background and Aims: The intratumoral microbiome has been reported to regulate the development progression of cancers. We aimed characterize microbial heterogeneity (IMH) establish microbiome-based molecular subtyping HBV-related HCC elucidate correlation between IMH tumorigenesis. Approach Results: A case-control study was designed investigate landscape characteristic signatures tissues adopting metagenomics next-generation sequencing. Microbiome-based established by nonmetric...
The Tat protein is essential for HIV type 1 (HIV-1) replication and may be an important virulence factor in vivo . We studied the role of viral pathogenesis by immunizing rhesus macaques with chemically inactivated toxoid challenging these animals intrarectal inoculation simian/human immunodeficiency virus 89.6PD. Immune had significantly attenuated disease lowered RNA, interferon-α, chemokine receptor expression (CXCR4 CCR5) on CD4 + T cells; features infection have been linked to vitro...
Erianin is a major bisbenzyl compound extracted from Dendrobium chrysotoxum Lindl., an important traditional Chinese herb. In recent years, growing body of evidence has proved the potential therapeutic effects erianin on various cancers, including hepatoma, melanoma, non-small-cell lung carcinoma, myelogenous leukemia, breast cancer, and osteosarcoma. Especially, pharmacological activities erianin, such as antioxidant anticancer activity, have been frequently demonstrated by plenty studies....
Osteoarthritis (OA) is a common degenerative joint disease. Effective drugs that can halt or decelerate osteoarthritis progression are still lacking. Omaveloxolone semisynthetic oleanane triterpenoid exerting antioxidative and anti-inflammatory effects. The present study aims to determine whether omaveloxolone has therapeutic effect on OA. Chondrocytes were treated with interleukin (IL)-1β establish an OA cell model in vitro. Indicators of viability, oxidative stress, inflammation, apoptosis...
Foodborne disease outbreaks (FBDOs) pose a significant threat to public health globally, leading substantial morbidity, mortality, and economic losses. However, the underlying causes impacts of FBDOs often remain underexplored in specific regions, limiting effectiveness targeted prevention strategies. This study aimed investigate epidemiological characteristics, causes, burden Jinhua city, Zhejiang province, China, between 2018 2022. Data were collected from national surveillance system,...
Objective Schizophrenia is a long-term neurological condition that impacts the quality of life patients. To explore expression miR-20b-5p in schizophrenia, to analyze diagnostic role and demonstrate affects progression schizophrenia. Methods The was detected by real-time quantitative PCR. schizophrenia analyzed receiver operating characteristic (ROC) curves. A schizophrenic rat model constructed injecting MK-801, anxiety cognition rats were evaluated an open-field test, novel object...
Abstract Background: Genome-wide association studies (GWAS) have identified more than 100 genetic loci for various cancers. However, only one is endometrial cancer. Methods: We conducted a three-stage GWAS including 8,492 cancer cases and 16,596 controls. After analyzing 585,963 single-nucleotide polymorphisms (SNP) in 832 2,682 controls (stage I) from the Shanghai Endometrial Cancer Genetics Study, we selected top 106 SNPs silico replication among 1,265 5,190 Australian/British II). Nine...
Introduction Despite the protection and management of skin has been paid more attention, effective countermeasures are still lacking for patients suffering from UV or chemotherapy with damaged skin. Recently, gene therapy by small interfering RNA (siRNA) emerged as a new therapeutic strategy lesions. However, siRNA not applied to due lack delivery vector. Methods Here, we develop synthetic biology that integrates exosomes artificial genetic circuits reprogram adipose mesenchymal stem cell...
We conducted a study of 152 HIV-1-seropositive individuals in order to evaluate the possible correlations between isolation HIV from peripheral blood mononuclear cells or plasma and CD4 cell counts. was isolated only 36% samples, rate closely related counts, increasing gradually 0% subjects with > 800 x 106/l 88% those < 100 cells. In contrast, 92% samples (99% 900 cells, 46% counts ≥ 106/l). Since most were positive, scoring method designed quantify cellular viral load. The results obtained...
Despite the critical progress of non-small cell lung cancer (NSCLC) therapeutic approaches, clinical outcomes remain considerably poor. The requirement developing novel interventions is still urgent. In this study, we showed for first time that diosbulbin C, a natural diterpene lactone component extracted from traditional Chinese medicine Dioscorea bulbifera L., possesses high anticancer activity in NSCLC.A549 and NCI-H1299 cells were used. inhibitory effects C on NSCLC proliferation...
The disruption of zinc (Zn) homeostasis has been implicated in cancer development and progression through various signaling pathways.Maintaining intracellular balance is crucial the context cancer.Human cells rely on two families transmembrane transporters, SLC30A/ZNT SLC39A/ZIP, to coordinate homeostasis.While some ZNTs ZIPs have linked progression, limited information available regarding expression patterns homeostasis-related genes their potential roles predicting prognosis developing...
Abstract Hepatocellular carcinoma (HCC) is a malignancy worldwide with one of the worst prognoses. Emerging studies have revealed that long noncoding RNAs (lncRNAs) contribute to HCC progression. This research probes expression and regulatory effect lncRNA SATB2-AS1 on development. Reverse transcription-polymerase chain reaction (RT-PCR) was applied measure profile in tissues adjacent non-tumor tissues. The impact SATB2-AS1, miR-3678-3p, or GRIM-19 cell proliferation, growth, migration,...
P < 0.05 or 0.01), and the occurrence of stress ulcer was also significantly lower than that in stage 2 patients (P 0.05).CONCLUSION: Comprehensive fluid resuscitation, early excision necrotic tissue, staged food ingestion, administration specific nutrients are essential strategies for preventing gastrointestinal complications lowering mortality severely burned patients.
Cholangiocarcinoma (CCA) is a serious health problem worldwide. The gut and bile microbiota have not been clearly characterized in patients with CCA, better noninvasive diagnostic approaches for CCA need to be established. aim of this study was investigate the characteristics patients. Forty-two 16 healthy normal controls (HNCs) were enrolled. DNA extracted from fecal samples subjected 16S rRNA gene analysis. We found that there significant differences species diversity, structure,...
At present, there is a lack of cheap, effective and convenient detection methods for hepatitis B-related liver fibrosis, especially in the developing area.To evaluate non-invasive significant advanced fibrosis stage chronic B virus (HBV) patients basic hospitals to assess their diagnostic utility.The study included 436 consecutive naive HBV individuals who had livers biopsied. They were examined one week using aspartate aminotransferase-to-aspartate aminotransferase ratio (AAR), age-platelet...