A5080213083- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Quantum Dots Synthesis And Properties
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Extracellular vesicles in disease
- Glycosylation and Glycoproteins Research
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Cytokine Signaling Pathways and Interactions
- Hepatitis C virus research
- Nanoparticle-Based Drug Delivery
- Nuclear reactor physics and engineering
- Nanocluster Synthesis and Applications
- Liver Disease Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
Southern Medical University
2016-2025
China Institute of Atomic Energy
2019-2024
Nanfang Hospital
2024
University of Science and Technology Liaoning
2022
National University of Singapore
2008-2012
Huazhong University of Science and Technology
2004-2008
In rheumatoid arthritis(RA) pathogenesis, activated RA fibroblast-1ike synoviocytes (RA-FLSs) exhibit similar proliferative features as tumor cells and subsequent erosion to cartilage will eventually lead joint destruction. Therefore, it is imperative search for compounds, which can effectively inhibit the abnormal activation of RA-FLSs, retard progression.3′3-Diindolylmethane (DIM), major product acid-catalyzed oligomerization indole-3-carbinol from cruciferous vegetables, has been reported...
// Bin Xiao 1, * , Daxiang Chen 1 Shuhong Luo 2, 3 Wenbo Hao Fangyan Jing 4 Tiancai Liu Suihai Wang Yan Geng 5 Linhai Li 6 Weiwen Xu Yajie Zhang 7 Xiaoqing Liao Daming Zuo 8 Yingsong Wu Ming Qiang Ma State Key Laboratory of Organ Failure Research, Institute Antibody Engineering, School Biotechnology, Southern Medical University, Guangzhou, 510515, Guangdong, China 2 RayBiotech, Inc., Guangzhou 510600, Norcross, GA 30092, USA Department Anorectal Surgery, Nanfang Hospital, Guangdong Province,...
Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease, in which activated RA fibroblast-1ike synoviocytes (RA-FLSs) are one of the main responsible for inducing morbidity. Previous reports have shown that RA-FLSs proliferative features similar to cancer cells, addition causing cartilage erosion eventually causes joint damage. Thus, new therapeutic strategies drugs, can effectively contain abnormal hyperplasia restrain development, necessary treatment RA. Tanshinone IIA...
In recent years, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has ascended with increasing number metabolic diseases such as obesity and diabetes, which will bring great medical burden to society. At present, multiple scientific experiments have found that CCR4-NOT complex can participate in regulating energy metabolism. This study is designed explore role mechanism transcription subunit 7 (CNOT7), a lipid deposition. To establish NAFLD cell model, palmitic acid (PA) was...
Abstract Despite recent technological advancements in cell tumor DNA (ctDNA) mutation detection, challenges persist identifying low-frequency mutations due to inadequate sensitivity and coverage of current procedures. Herein, we introduce a super-sensitivity specificity technique for detecting ctDNA mutations, named HiCASE. The method utilizes PCR-based CRISPR, coupled with the restriction enzyme. In this work, HiCASE focuses on testing series EGFR provide enhanced detection technology...
Scheme of the amplification-free digital droplet assay. Two innovations: (1) polystyrene capture beads to concentrate target RNA from a dilute sample and (2) “confinement” effect amplifies concentration molecule.
Abstract Gliomas represent a prevalent form of primary brain tumors, with temozolomide (TMZ) serving as the established first-line therapeutic option. Nevertheless, effectiveness TMZ is hindered by development chemoresistance. Recent investigations have underscored correlation homologous recombination repair (HRR), pivotal mechanism responsible for mending DNA double-strand breaks, resistance in glioma treatment. This review centers on elucidating significance HRR management gliomas,...
Micropeptides (≤100 amino acids) are essential regulators of physiological and pathological processes, which can be encoded by small open reading frames (smORFs) derived from long non-coding RNAs (lncRNAs). Recently, lncRNA-encoded micropeptides have been shown to roles in tumorigenesis. Since translated smORF identification remains technically challenging, little is known their functions cancer. Therefore, we created classifiers identify smORFs lncRNAs based on ribosome-protected fragment...
Oral squamous cell carcinoma (OSCC) is one of the most lethal malignancies worldwide and common type oral cancer, characterized by invasive growth, frequent regional metastases, high recurrence, poor prognosis. In current study, we investigated use long non-coding RNAs (lncRNAs), tumor-specific growth factor (TSGF), antigen (SCCA) as potential biomarkers for OSCC screening.LncRNA expression was measured microarray analysis in three sets paired normal mucosal tissues. The lncRNAs involved...
Development of sensitive homogeneous assays is a high-priority research target for clinical diagnostics. Quantum dots (QDs) present favorable photophysical properties, which implies their potential as an exceptional dye in fluorescence detection. QDs-based biosensors have been described the literature; however, few them truly progressed to widespread usage. In this work, chemiluminescent detecting biosensor fabricated using QDs-doped polystyrene nanospheres sensitively detect biomarkers...
Despite burgeoning development of nanoplatform made in the past few years, it remains a challenge to produce drug nanocarrier that enables requested on/off release. Thus, this study aimed develop an ideal near-infrared light-triggered smart for targeted imaging-guided treatment cancer tactfully integrated photothermal therapy with chemotherapy accurately control release time and dosage. Methods: This delivery system was composed Ag2S QD coating dendritic mesoporous silica (DMSN), which acted...