A5029095876- Rheumatoid Arthritis Research and Therapies
- Gout, Hyperuricemia, Uric Acid
- Cytokine Signaling Pathways and Interactions
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Systemic Lupus Erythematosus Research
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- Synthesis and biological activity
- Dermatology and Skin Diseases
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Plant Pathogens and Fungal Diseases
- Connective Tissue Growth Factor Research
- Case Reports on Hematomas
- Cell death mechanisms and regulation
- Parvovirus B19 Infection Studies
- Musculoskeletal synovial abnormalities and treatments
- Ginseng Biological Effects and Applications
- Chronic Lymphocytic Leukemia Research
Zhujiang Hospital
2019-2024
Southern Medical University
2019-2024
General Hospital of Guangzhou Military Command
2014-2022
421 Hospital of PLA
2008
In rheumatoid arthritis(RA) pathogenesis, activated RA fibroblast-1ike synoviocytes (RA-FLSs) exhibit similar proliferative features as tumor cells and subsequent erosion to cartilage will eventually lead joint destruction. Therefore, it is imperative search for compounds, which can effectively inhibit the abnormal activation of RA-FLSs, retard progression.3′3-Diindolylmethane (DIM), major product acid-catalyzed oligomerization indole-3-carbinol from cruciferous vegetables, has been reported...
Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease, in which activated RA fibroblast-1ike synoviocytes (RA-FLSs) are one of the main responsible for inducing morbidity. Previous reports have shown that RA-FLSs proliferative features similar to cancer cells, addition causing cartilage erosion eventually causes joint damage. Thus, new therapeutic strategies drugs, can effectively contain abnormal hyperplasia restrain development, necessary treatment RA. Tanshinone IIA...
Kirenol is a diterpenoid extracted from the Chinese herbal medicine Siegesbecki-ae. Siegesbeckiae has been used to treat rheumatoid arthritis (RA) in China for sever-al centuries. RA characterized by proliferation of synoviocytes inflamed synovia, as well their expression inflammatory cytokines. In present study, we found that inhibited migration, invasion, and proinflammatory IL-6 secretion RA-associated synovial fibroblasts (FLS) at concentration 100 - 200ug/ml vitro. Proinflammatory...
Psoriatic arthritis (PsA) is a unique immune-mediated disease with cutaneous and osteoarticular involvement. However, only few studies have explored the susceptibility of involvement in psoriasis (Ps) at genetic level. This study investigated biomarkers associated participation potential shared molecular mechanisms for PsA ankylosing spondylitis (AS). Methods The RNA-seq data Ps, PsA, AS Gene Expression Omnibus (GEO) database were obtained. First, we used limma package weighted gene...
Tanshinone IIA (Tan IIA), a phytochemical derived from the roots of Salvia miltiorrhiza BUNGE, has been documented with anti-tumor, pro-apoptotic, and anti-inflammatory activities. long used to treat rheumatoid arthritis (RA). Apoptosis induction RA-fibroblast-like synoviocytes (FLS) was suggested be potential therapeutic approach for RA. The aim this study investigate whether Tan promotes apoptosis in RA-affected FLS. In study, viability an immortalized FLS cell line RA patients assessed by...
Bone growth and remodeling is inhibited by denervation in adults children, resulting alterations of linear bone mass increased risk for osteoporosis pathologic fractures. Transforming factor beta (TGF-β) isoforms are a key group factors that enhance formation. To explore the relation between denervation-induced reduction formation TGF-β gene expression, we measured mRNA levels mouse found decreased TGF-β1, TGF-β2 TGF-β3. These changes were accompanied diminishing weight loss, mineral density...
Abstract Aim To investigate the effects on hypercholesterolemia and hypertriglyceridemia in gouty patients receiving uric acid‐lowering therapy (UALT). Methods A retrospective study was performed from January 2015 to December 2017 UALT. total of 124 with or who were administered UALT monitored. Of gout, 52 treated febuxostat, 29 allopurinol, 43 benzbromarone. Cholesterol triglyceride levels recorded analyzed following treatment for 8‐10 weeks. Results We compared efficacy All therapies...
Cysteine‑rich angiogenic inducer 61 (Cyr61) is a novel molecule that has been shown to be increased in the synovial tissues of patients with rheumatoid arthritis (RA). The present study was conducted order investigate role Cyr61 pathogenesis RA. A human genome‑wide gene assay used screen expression obtained from four RA and three osteoarthritis (OA). To examine phenotype RA‑fibroblast‑like (FLS) cells, RA‑FLS cells knocked down using small interfering RNA (siRNA). Normal FLS transduced...
Abstract Synovial fibroblasts (SFs) of rheumatoid arthritis (RA) are phenotypically aggressive, typically progressing into arthritic cartilage degradation. Throughout our study, we made explorations the effects microRNA‐135a (miR‐135a) on SFs involved in RA by mediating phosphatidylinositol 3‐kinase (PI3K)/AKT signaling pathway via regulation regulatory subunit 2 (PIK3R2). The expression PI3K was higher, PIK3R2 lower, and AKT phosphorylated synovial tissues, relative to levels found normal...
Abstract Aim IL‐38 is a recently discovered inflammatory factor that belongs to the IL‐1 family and has full‐length truncated forms. Clinical findings demonstrated serum levels in people with infectious autoimmune diseases are significantly different from those healthy people, but form remains unclear. We keenly interested learning more about regulatory role of rheumatoid arthritis (RA), classic disease. Methods RA‐fibroblast‐like synoviocytes (RA‐FLS) were isolated six RA patients...
Three new antibacterial spirooxindole alkaloids, spirobrefeldins A-C (1-3), together with four known analogs, spirotryprostatin M (4), G (5), 12β-hydroxyverruculogen TR-2 (6), and 12α-hydroxyverruculogen (7), were isolated from terrestrial fungus Penicillium brefeldianum. All the compounds elucidated extensively by interpretation of their NMR (1D 2D) spectra high-resolution mass data, absolute configurations determined computational chemistry CD spectra. The spiro carbon C-2 in (5) C...
Rationale: A 27-year-old woman with a history of systemic lupus erythaematosus (SLE) developed hemophagocytic syndrome (HPS) secondary due to an unrecognized infection that led severe SLE prolonged recovery. Patient concerns: The patient showed high spiking fever and myalgia. Laboratory data revealed pancytopenia immunological abnormalities. Pulse methylprednisone plus intravenous immunoglobulin (IVIG) failed improve the clinical symptoms laboratory data. Diagnoses: As activated macrophages...
Human ubiquitin-conjugating enzyme E2, also known as UbcH10, is defined a cyclin-selective ubiquitin carrier protein and essential for selective degradation of many short-lived proteins in eukaryotic cells. Recently more data show that UbcH10 could be potential cancer biomarker. In this study, we have developed monoclonal antibody (MAb) against using an expression recombinant protein. Hybridomas F001, F007, F008 with high affinities belong to IgG1 subclass κ light are highly specific UbcH10....
<title>Abstract</title> Gitelman syndrome (GS) is an autosomal recessive disorder characterized by hypokalaemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. Little research has been done on the association between GS hemodynamic abnormalities. In present case report, a 58-year-old female patient developed refractory vasodilatory shock after undergoing lumbar spine surgery died resuscitation, which was considered to be related instability complicated GS.