A5102748684- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Phytochemistry and biological activity of medicinal plants
- Eicosanoids and Hypertension Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Estrogen and related hormone effects
- Case Reports on Hematomas
- Synthesis and biological activity
- Immune Response and Inflammation
- Radioactivity and Radon Measurements
- Cancer-related gene regulation
- Cytokine Signaling Pathways and Interactions
- Phytochemistry and Bioactive Compounds
- Cancer, Lipids, and Metabolism
- Ginseng Biological Effects and Applications
- Connective Tissue Growth Factor Research
- Systemic Sclerosis and Related Diseases
- Cancer Research and Treatments
- Traditional Chinese Medicine Analysis
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
- Inflammasome and immune disorders
Guangzhou University of Chinese Medicine
2013-2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2017
University Medical Center Utrecht
2017
Chinese University of Hong Kong
2010-2012
Bladder cancer is one of the most malignant tumors closely associated with macrophages. Polyporus polysaccharide (PPS) has shown excellent efficacy in treating bladder minimal side effects. However, molecular mechanisms underlying effects PPS inhibiting remain unclear. In this study, we used macrophages cultured alone or T24 human cell culture supernatant as study models. We found that enhanced activities IFN-γ-stimulated RAW 264.7 macrophages, by release inducible nitric oxide synthase...
Background: Currently, there is a global attempt to identify potential anti-cancer agents with low toxicity. Previous studies have found that glycyrrhizin exerts action toxicity through suppressing thromboxane A2 (TxA2) in lung cancer cell lines. However, these effects not yet been determined animal models of cancer. Methods: Human adenocarcinoma xenografts were established nude mice by the introduction A549 cells stable transfection TxA2 receptor (TPα). The model was confirmed hematoxylin...
Background/Aims: The effects of glycyrrhizin treatment in lung cancer remain undetermined, despite extensive studies the anti-tumor activities glycyrrhizin. Methods: Lung adenocarcinoma A549 and NCI-H23 cell lines were used this study. Cell growth was examined by MTS assays, while apoptosis cycle determined flow cytometric analysis. Both real-time PCR western blotting to examine expression levels thromboxane synthase (TxAS), TxAS activity measured using EIA detection biosynthesis TxA2....
<title>Abstract</title> <bold>Background</bold> Hyperuricemia and gout are metabolic disorders associated with an increased risk of all-cause cardiovascular mortality. Oxidative stress plays a crucial role in their pathogenesis, dietary lifestyle modifications may offer protective benefits. The Balance Score (OBS), integrative measure oxidative balance, has been linked to chronic disease outcomes. However, its association mortality individuals hyperuricemia remains unclear. This study aims...
18β-Glycyrrhetinic acid (18β-GA) is a bioactive component of licorice. The anti-cancer activity 18β-GA has been studied in many cancer types, whereas its effects lung remain largely unknown. We first showed that effectively suppressed cell proliferation and inhibited expression as well thromboxane synthase (TxAS) non-small (NSCLC) cells A549 NCI-H460. In addition, the administration did not have any additional inhibitory effect on decrease induced by transfection with TxAS small interference...
Cysteine‑rich angiogenic inducer 61 (Cyr61) is a novel molecule that has been shown to be increased in the synovial tissues of patients with rheumatoid arthritis (RA). The present study was conducted order investigate role Cyr61 pathogenesis RA. A human genome‑wide gene assay used screen expression obtained from four RA and three osteoarthritis (OA). To examine phenotype RA‑fibroblast‑like (FLS) cells, RA‑FLS cells knocked down using small interfering RNA (siRNA). Normal FLS transduced...
Abstract Many studies have shown that 4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK), the most potent carcinogen present in tobacco smoke, can induce lung tumor growth. We previously demonstrated activation of extracellular regulated protein kinases (ERK) and cAMP response element-binding (CREB) is responsible for pro-survival proliferative effects thromboxane A2 (TxA2) its receptor (TP) human cancer cells stimulated with NNK (reported oncogene journal). In current study, we further...