A5100636522- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Traditional Chinese Medicine Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer Mechanisms and Therapy
- Case Reports on Hematomas
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Acupuncture Treatment Research Studies
- Pancreatitis Pathology and Treatment
- Spine and Intervertebral Disc Pathology
- Traditional Chinese Medicine Analysis
- Cell Adhesion Molecules Research
- Urological Disorders and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Liver physiology and pathology
- Gastric Cancer Management and Outcomes
- Autoimmune and Inflammatory Disorders Research
- Thermoregulation and physiological responses
- Thermal Regulation in Medicine
- Psoriasis: Treatment and Pathogenesis
- Coronary Artery Anomalies
- Spondyloarthritis Studies and Treatments
Sun Yat-sen Memorial Hospital
2017-2025
Peking University
2008-2025
Guilin Medical University
2025
Peking University Third Hospital
2025
Guangzhou University of Chinese Medicine
2020-2025
Sun Yat-sen University
2017-2024
Shandong Provincial QianFoShan Hospital
2024
Shandong First Medical University
2024
Peking University First Hospital
2020-2021
Fudan University
2019-2021
Abstract Upconversion photodynamic therapy (UC-PDT), which integrates upconversion nanoparticles (UCNPs) with photosensitizers (PSs), presents a promising advancement in the field of phototherapy. However, despite extensive studies focused on design and synthesis UCNPs, there is paucity systematic research mechanisms underlying synergistic effects. Here we have synthesized core@dotted-shell (CDSNPs) covalently tethered them two distinct PSs, thereby constructing dual-PS UC-PDT system high...
<title>Abstract</title> <bold>Background</bold> Hyperuricemia and gout are metabolic disorders associated with an increased risk of all-cause cardiovascular mortality. Oxidative stress plays a crucial role in their pathogenesis, dietary lifestyle modifications may offer protective benefits. The Balance Score (OBS), integrative measure oxidative balance, has been linked to chronic disease outcomes. However, its association mortality individuals hyperuricemia remains unclear. This study aims...
Heterozygous mutation of CLCN7 (R286W) is commonly found in patients with benign autosomal dominant osteopetrosis. However, there no evidence from animal models to confirm that it a disease mutation. And the characteristics bone marrow cell (BMC) landscape osteopetrosis at single-cell level are completely unknown till now. In this study, we generated first type 2 (ADO2) mouse model typical phenotypes carried Clcn7 (r284w) corresponding observed human using gene editing technology. then,...
Triple combination conversion therapy, involving transcatheter arterial chemoembolization (TACE) or hepatic infusion chemotherapy (HAIC) combined with tyrosine kinase inhibitors (TKIs) and immune checkpoint (ICIs), has shown an encouraging objective response rate (ORR) successful surgery in initially unresectable hepatocellular carcinoma (HCC). However, the safety long-term survival outcomes of subsequent liver resection after still remain to be validated. From February 2019 2023, 726...
The prognosis of pancreatic adenosquamous carcinoma (PASC) after surgery is poor. purpose this study was to clarify the prognostic factors PASC and evaluate efficacy combination chemoradiotherapy.The patients' data retrieved from Surveillance, Epidemiology, End Results database (SEER) between 2004 2015 were stratified analyzed in study. univariate multivariate analysis used for overall survival (OS) cancer-specific (CSS).T staging, M chemotherapy radiotherapy independent indicator resection...
Platinum-based chemotherapy resistance is a key factor of poor prognosis and recurrence in hepatocellular carcinoma (HCC). Herein, RNAseq analysis revealed that elevated tubulin folding cofactor E (TBCE) expression associated with platinum-based resistance. High TBCE contributes to worse prognoses earlier among liver cancer patients. Mechanistically, silencing significantly affects cytoskeleton rearrangement, which turn increases cisplatin-induced cycle arrest apoptosis. To develop these...
Background Clinically relevant postoperative pancreatic fistula (CR-POPF) remains a severe and challenging complication of pancreaticoduodenectomy (PD). This study aimed to establish novel nomogram-based diagnostic model for the early detection CR-POPF in patients subjected PD. Methods Consecutive who underwent PD Zhongshan Hospital, Fudan University from December 2018 October 2020 were retrospectively enrolled. Univariate multivariate logistic regression analyses performed identify...
e16221 Background: The CARES-310 study has demonstrated that the combination of anti-PD-1 antibody camrelizumab and VEGFR2 tyrosine kinase inhibitor apatinib exhibits improved progression-free survival (PFS) overall (OS) in patients with advanced hepatocellular carcinoma (HCC). We conducted this to investigate whether addition anti-PD-L1 adebrelimab would further improve clinical outcomes. Methods: This is a prospective, phase 1b/2 trial employing i3 + 3 dose escalation design. Eligibility...
<b><i>Objectives:</i></b> The aim of the study was to present our modified flap pyeloplasty techniques for recurrent ureteropelvic junction obstruction (UPJO) with a long proximal ureteral stricture and compare outcomes laparoscopic robotic procedures. <b><i>Materials Methods:</i></b> Between March 2018 January 2020, 21 patients underwent or UPJO stricture. Our surgical modifications included “wishbone” anastomosis “ureteral plate” technique....
It is unclear if the modified extended pancreaticoduodenectomy (PD) has better outcome superior conventional PD for patients with pancreatic head carcinoma (PHC). The objective of this study to compare survival outcomes classic procedure and PHC.A total 7,084 resected PHC from SEER database 2004 2014 were stratified. With utilization propensity score matching (PSM), patient baseline characteristics balanced decrease bias. Overall (OS) cancer-specific (CSS) analyzed in both groups.Of...
Department of Orthopedic Surgery, The First Affiliated Hospital Shandong Medical University & Provincial Qianfoshan Hospital, Key Laboratory Rheumatic Disease and Translational Medicine, Jinan, China Changjun Chen Qingwei Ma contributed equally to this work. Sponsorships or competing interests that may be relevant content are disclosed at the end article. Published online ■ *Corresponding author. Address: China: +86 053189269860. E-mail address: [email protected] (C. Chen). : (L. Zhang)....
e16227 Background: Hepatocellular carcinoma (HCC) with solitary large tumor (≥ 5 cm) and microvascular invasion (MVI) was associated high 5-year recurrence rate poor survival prognosis. Postoperative adjuvant hepatic arterial infusion chemotherapy (HAIC) found to improve the recurrence-free (RFS) acceptable safety profiles in HCC patients MVI. However, prognosis of who received HAIC after hepatectomy still remain far from satisfactory. Several studies have shown that combination tyrosine...
To explore the impact of dietary sodium-intake on residual renal function in patients undergoing peritoneal dialysis (PD).Thirty-three PD with stable were regularly followed up for 12 months. The daily sodium intake was calculated based 3-day record. Based mean intake, enrolled divided into low-salt group (sodium intake≤3.0 g/day, 19 patients) and high-salt intake>3.0 14 patients). baseline data recorded, indicators tested. followed-up at 3-month intervals, their urine volume,...
Objective: To investigate the value of platelet count in predicting efficacy rituximab treatment chronic primary immune thrombocytopenia (ITP). Methods: A retrospective study was conducted 103 ITP patients hospitalized our medical center between January 2011 and December 2014. The sensitivity, specificity, positive predictive (PPV), negative (NPV) different time points were analyzed for predictor response. Optimal cutoff values established using ROC analysis. Results: total included study....