A5101848296- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Spine and Intervertebral Disc Pathology
- Bone and Joint Diseases
- Anesthesia and Pain Management
- DNA and Nucleic Acid Chemistry
- Infectious Diseases and Tuberculosis
- Cervical and Thoracic Myelopathy
- Plant Pathogens and Fungal Diseases
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Mesenchymal stem cell research
- Bone health and treatments
- Spinal Fractures and Fixation Techniques
- Orthopaedic implants and arthroplasty
- Case Reports on Hematomas
- Plant Disease Resistance and Genetics
- Total Knee Arthroplasty Outcomes
- RNA modifications and cancer
- Spinal Hematomas and Complications
- Fungal Plant Pathogen Control
- Bone Metabolism and Diseases
- Scoliosis diagnosis and treatment
- Enhanced Recovery After Surgery
Shandong Provincial QianFoShan Hospital
2023-2025
Shandong First Medical University
2023-2025
Sichuan University
2020-2024
West China Hospital of Sichuan University
2020-2024
Hunan Agricultural University
2024
Second Affiliated Hospital of Zhejiang University
2024
Molina Center for Energy and the Environment
2024
Anhui Agricultural University
2023
Capital Medical University
2022
Shougang (China)
2022
Abstract The Poisson–Boltzmann equation (PBE) is an established model for the electrostatic analysis of biomolecules. development advanced computational techniques solution PBE has been important topic in past two decades. This article presents a matched interface and boundary (MIB)‐based software package, MIBPB solver, analysis. unique feature that it first technique‐based solver rigorously enforces flux continuity conditions at dielectric between biomolecule solvent. For protein molecular...
Glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH) is a serious bone disease that often affects young individuals. Bone grafting combined with core decompression mainly used in clinic to treat GC-ONFH. However, outcome usually not satisfactory, as expected. Here, we report an engineered exosome-functionalized extracellular matrix-mimicking hydrogel for promoting repair Compared Con-Exo, exosomes secreted by marrow stem cells (BMSCs) conventional culture medium, Li-Exo,...
Background: Whether an adductor canal block (ACB) is more effective when administered before or after total knee arthroplasty (TKA) unclear. This study compared pain, stress, and functional outcomes between patients who received the surgery those surgery. Methods: In this double-blinded trial, 100 at our hospital were randomized to receive ACB either 30 minutes general anesthesia postoperatively in post-anesthesia care unit (PACU). All periarticular local infiltration analgesia during The 2...
Abstract The specific binding of ligands is the first step gene expression or translation regulation by riboswitches. However, understanding mechanism still difficult because tertiary structures riboswitch aptamers are available almost only for ligand-bound state at present. In this paper we hope to give some insights into problem through studies role ligand-aptamer interaction in structural organization add A-riboswitch aptamer, based on crystal structure aptamer. We use all-atom molecular...
Abstract Purpose The aim of this study was to determine mid-and-long term follow-up results patients with early femoral head osteonecrosis who were treated by modified free vascularized fibular grafting combined core decompression and bone grafting. Methods Forty-four at ONFH included in study. Visual analog scale (VAS) pain scores, range hip motion (ROM), Harris score (HHS) recorded assess the clinical outcome; Western Ontario McMaster Osteoarthritis index (WOMAC) scores Short Form 36...
Background: Osteonecrosis of the femoral head (ONFH) is a complex disease resulting in degeneration hip joint. The pathogenesis ONFH largely unknown, but alterations immunological factors have been proposed to play role. Methods: We included 109 patients with and age-, sex-, body mass index-matched healthy controls this study. percentage circulating CD3 + , CD4 CD8 lymphocytes among total was identified by flow cytometry compared between cases controls. Subgroup analysis within each...
Minimum Free Energy Path (MFEP) is very important in computational biology and chemistry. The barrier the path related to reaction rate, start-to-end difference gives relative stability between reactant product. All these information significant experiment practical application. But finding MFEP not an easy job. Lots of degrees freedom make computation complicated time consuming. In this paper, we use Steepest Descent (SDP) accelerate sampling MFEP. SHAKE algorithm Lagrangian multipliers are...
Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro-inflammatory high mobility group protein 1 (HMGB1). Here, we report that can suppress (a) HMGB1-induced overexpression aquaporin-1 (AQP1) water channel in cells (b) increases cell permeability. This...
Abstract Motivation: After 10-year investigations, the folding mechanisms of β-hairpins are still under debate. Experiments strongly support zip-out pathway, while most simulations prefer hydrophobic collapse model (including middle-out and zip-in pathways). In this article, we show that all pathways can occur during but with different probabilities. The pathway is probable one. This in agreement experimental results. We came to our conclusions by 38 100-ns room-temperature all-atom...
Riboswitches play roles in transcriptional or translational regulation through specific ligand binding of their aptamer domains. Although a number ligand-bound complex structures have been solved, it is important to know ligand-free conformations the aptamers order understand mechanism by ligands. In this paper, preQ1 riboswitch domain from Bacillus subtilis studied overall 1.5 μs all-atom molecular dynamics simulations We found that has stable state with folded P1-L3 and open pocket. The...
Yong Jiang, He Liu, Wen-jing Hai-bin Tong, Chang-jun Chen, Fu-gui Lin, Yan-hang Zhuo, Xiao-zhen Qian, Zeng-bin Wang, Yu Peng Zhang, and Hong-liang Jia. Mol. Cells 2016;39:292-8. https://doi.org/10.14348/molcells.2016.2223
Both bone mesenchymal stem cells (BMSCs) and their exosomes suggest promising therapeutic tools for regeneration. Lithium has been reported to regulate BMSC function engineer improve regeneration in patients with glucocorticoid-induced osteonecrosis of the femoral head. However, mechanisms by which lithium promotes osteogenesis have not elucidated. Here, we demonstrated that BMSCs via lithium-induced increases secretion exosomal Wnt10a activate Wnt/β-catenin signaling, whose is correlated...